Have No Fear, MitoQ
            <sub>10</sub>
            Is Here

Barbato, John C.

doi:10.1161/hypertensionaha.109.135533

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Just as it is becoming acceptable to add CoE Q10 to reverse myopathy in patients on statins 12 rather than on discontinuation, it may not be out of place to suggest considering CoE Q10 supplementation in other statin-induced side effects particularly and generally for cardiovascular diseases. As posited in a paper, 18 mitochondrial oxidative defense integrity has a place in onset and severity of cardiovascular diseases. When in equilibrium such diseases are checked, but any disequilibrium results in disease manifestation.…”

Section: Discussionmentioning

confidence: 95%

Reversal of statin-induced memory dysfunction by co-enzyme Q10: a case report

Okeahialam

2015

VHRM

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Statins are useful in the armamentarium of the clinician dealing with dyslipidemia, which increases cardiovascular morbi-mortality in hypertensive and diabetic patients among others. Dyslipidemia commonly exists as a comorbidity factor in the development of atherosclerotic cardiovascular disease. Use of statins is however associated with side effects which at times are so disabling as to interfere with activities of daily living. There are various ways of dealing with this, including use of more water-soluble varieties, intermittent dosing, or use of statin alternatives. Of late, use of co-enzyme Q10 has become acceptable for the muscle side effects. Only one report of any benefit on the rarely reported memory side effect was encountered by the author in the search of English medical literature. This is a report of a documented case of a Nigerian woman with history of statin intolerance in this case, memory dysfunction despite persisting dyslipidemia comorbidity. Her memory dysfunction side effect which interfered with activities of daily living and background muscle pain cleared when coenzyme Q10 was administered alongside low dose statin. Her lipid profile normalized and has remained normal. It is being recommended for use when statin side effects (muscle- and memory-related) impair quality of life and leave patient at dyslipidemia-induced cardiovascular morbi-mortality.

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Section: Discussionmentioning

confidence: 95%

Reversal of statin-induced memory dysfunction by co-enzyme Q10: a case report

Okeahialam

2015

VHRM

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“…For instance, IEX-1 null mutation specifically renders T helper 1 (Th1) cells to apoptosis, while augmenting the differentiation of Th17 cells, giving rise to Th17-biased inflammatory responses [22] and aggravated arthritis in IEX-1 knockout (KO) mice immunized with collagen I, in sharp contrast to Th1-skewed immune responses and T-cell lymphoma observed in IEX-1-transgenic mice [23–25]. The increases in Th17 differentiation and Th1 apoptosis were reversed by treatment of the mice with antioxidant N -acetylcysteine or mitochondrial-targeted antioxidant mitoquinone [23,26]. Moreover, in obesity, macrophages in adipose tissues elicit a strong inflammatory reaction by changing their phenotype from an anti-inflammatory M2 state to a pro-inflammatory M1 state.…”

Section: Complex Cellular Functions Of Iex-1mentioning

confidence: 99%

Immediate early response gene X-1, a potential prognostic biomarker in cancers

Ustyugova

Liang

et al. 2013

Expert Opinion on Therapeutic Targets

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Introduction The immediate early response gene X-1 (IEX-1) plays a pivotal role in the regulation of cell apoptosis, proliferation, differentiation and metabolism. Deregulation of IEX-1 expression has been confirmed in multiple cancers in humans, in association with either poor or better prognosis depending on the type and progression stages of the cancer. Areas covered This review summarizes clinical studies of altered IEX-1 expression in ovarian, pancreatic, blood, breast and colorectal cancers, lymphoma and myeloma. The authors also outline the current understandings of the complex functions of IEX-1 gained from studies with animal models and tumor cell lines so as to help us comprehend the significance of the clinical findings. Expert opinion IEX-1 holds great promise to be a valuable biomarker, either alone or in combination with other genes, for monitoring progression of some cancers. IEX-1 expression is highly sensitive to environmental cues and distinct between normal and cancer cells. However, use of IEX-1 as a biomarker remains a significant challenge because too little is understood about the mechanism underlying the diverse activities of IEX-1 and a standardized clinical assay for IEX-1 detection and validation of clinical results across different studies are still critically lacking.

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“…Several other studies have used MitoQ10 in a variety of animal models of disease [102] and the results indicate that MitoQ10 protects against liver damage in an animal model of sepsis [103], contributes to the aetiology of the metabolic syndrome and atherosclerosis in a mouse model [104] protects pancreatic β-cells against oxidative stress and improves insulin secretion in glucotoxicity and glucolipotoxicity [105] and even protects against oxidative stress and cell death in the brain of rats exposed to the insecticide dichlorvos [106]. Importantly, the first clinical evidence of a potential benefit of MitoQ10 in humans comes from a study that MitoQ10 reduces liver damage induced by hepatitis virus infection [107].…”

Section: Antioxidant Defensesmentioning

confidence: 99%