Have Volume-based Parameters of Positron Emission Tomography/Computed Tomography Prognostic Relevance for Patients With Potentially Platinum-responsive Recurrent Ovarian Cancer? A Single Center Italian Study

Abstract

Background/Aim: To assess the prognostic relevance of volume-based parameters [whole body (wb)metabolic tumor volume (MTV) and wb-total lesion glycolysis (TLG)] of pretreatment PET/CT in patients with potentially platinum-responsive recurrent ovarian cancer.Patients and Methods: This retrospective investigation analyzed 67 patients at first relapse. Results: At univariate analysis, post-relapse survival and overall survival correlated with residual disease after primary surgery (RD) (p=0.015 and 0.049, respectively), time to recurrence (p=0.005 and p=0.0003), number of recurrence sites (p=0.001 and p=0.0005), treatment at recurrence (p=0.044 and 0.043) and wb-MTV (p=0.023 and 0.021) but not with wb-TLG. RD, time to recurrence and number of recurrence sites, but not wb-MTV, were independent prognostic variables for post-relapse survival, and time to recurrence and number of recurrence sites, but not wb-MTV, were independent prognostic factors for overall survival. Conclusion: Volume-based parameters of PET/CT are not independent predictors of clinical outcome in potentially platinum-responsive recurrent ovarian cancer.

Does the primary treatment sequence affect post‐relapse survival in recurrent epithelial ovarian cancer? A real‐world multicentre retrospective study

“…For these patients, NACT gave them the opportunity for debulking surgery, reducing postoperative complications and ameliorating the optimal resection rate. A higher age and residual disease at PDS or IDS were independently poor prognostic factors for post‐relapse survival (HR 1.22, 95% CI 1.0–1.5, p = 0.026; HR 1.76, 95% CI 1.06–2.95, p = 0.031, respectively), 38,39 which might associated with comorbidities and intolerance to the standard chemotherapy dose in older patients and high susceptibility to chemoresistance in patients with initial residual lesions.…”

Predicting epithelial ovarian cancer prognosis: correlation of posttreatment 18F-fluorodeoxyglucose positron emission tomography-computed tomography metabolic parameters, serum carbohydrate antigen, and human epididymis protein levels with overall survival

“…Notably, MTV and TLG, as volume-based parameters, represent the metabolic activity across the tumor. Furthermore, whole-body MTV (WBMTV) and whole-body TLG (WBTLG) account for the metabolic burden of all lesions, offering a comprehensive view of the tumor’s functional activity ( 16 , 17 ). Lee et al reported TLG to be an independent predictor of progression-free survival (PFS) ( 18 ), but this observation was based on baseline PET/CT before treatment.…”

Serum Tumor Markers Combined with 18F-FDG PET/CT Volumetric Metabolic Parameters in the Prognosis of Ovarian Cancer

“…Metabolic tumor volume (MTV), which is a volume measurement of tumor cells with high glycolytic activity, and total lesion glycolysis (TLG), which is the product of metabolic tumor volume (MTV) and mean standardized uptake value (SUV mean) of the lesion, both measure the overall change in tumor glycolysis. Additionally, WB-MTV and WB-TLG represent the sum of the metabolic burden of all lesions throughout the body, providing maximum multidimensional information of the lesions [6].…”