Haversian microstructure in bovine femoral cortices: An adaptation for improved compressive strength

Mayya, Ashwij; Banerjee, Anuradha; Rajesh, R.

doi:10.1016/j.msec.2015.10.047

Cited by 25 publications

(28 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to alveolar bone, CD31 signal in aged tibia was barely detectable by immunostaining, as is consistent with the literature (Kusumbe et al, 2014) (data not shown). Notably, due to the differences in tissue composition of alveolar bone (Nanci, 2013) and long bones (Mayya, Banerjee, & Rajesh, 2016), the flow cytometric percentage of H‐ECs during aging can only be compared within the same tissue. Comparing the percentage of H‐ECs between alveolar bone and tibia would lead to misinterpretation of the amount of H‐type vessels in local tissues.…”

Section: Resultsmentioning

confidence: 99%

H‐type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing

et al. 2020

View full text Add to dashboard Cite

Objectives We aimed to investigate whether skeletal‐specific H‐type blood vessels exist in alveolar bone and how they function in alveolar bone remodeling. Materials and Methods H‐type vessels with high expression of CD31 and Endomucin (CD31hiEmcnhi) were immunostained in alveolar bone. Abundance and age‐related changes in CD31hiEmcnhi endothelial cells (H‐ECs) were detected by flow cytometry. Osteoprogenitors association with H‐type vessels and bone mass were detected in tooth extraction model of alveolar bone remodeling by immunohistofluorescence and micro‐CT, respectively. Transcription and expression of H‐EC feature genes during in vitro Notch inhibition were measured by RT‐qPCR and immunocytofluorescence. Results We verified that H‐type vessels existed in alveolar bone, the abundance of which was highest at infancy age, then decreased but maintained a constant level during aging. In tooth extraction model, H‐ECs significantly increased with concomitant perivascular accumulation of Runx2+ osteoprogenitors and gradually augmentation of bone mass. Notch inhibition of in vitro cultured H‐ECs resulted in decreased expression levels of Emcn and hes1, but not Pecam1 or Kdr genes, with decreased expression levels of H‐EC numbers, accordingly. Conclusions The present study suggests that H‐type vessels promote osteogenesis during alveolar bone remodeling. Notch signaling pathway regulates expression of Emcn and possibly determines fate and functions of alveolar H‐ECs.

show abstract

Section: Resultsmentioning

confidence: 99%

H‐type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, several studies have used dry bone properties as an indicator for comparative bone quality considering that the testing methodologies for dry bone are significantly simpler [49 -52]. In the optical micrograph of the longitudinal face, shown in figure 1b, layers of woven bone were present between arrays of primary osteons that is typical of plexiform bone [14,25,31].…”

Section: Micro-computed Tomography Scans and Compression Testingmentioning

confidence: 99%

“…In tension, Haversian bone has lower strength [17,18], fracture toughness [19,20] as well as resistance to fatigue crack growth [21][22][23]. In compression, however, Haversian bone has higher strength that is proportional to the extent of remodelling [24,25]. A significant factor affecting the mechanical properties within the same type of bone, whether cancellous or compact, is its porosity.…”

Section: Introductionmentioning

confidence: 99%

“…From experimental characterization, it is evident that elastic modulus as well as strength decrease with mean porosity as a power law [17,18,[26][27][28]. On the contrary, in cortical/compact bone, Haversian microstructure has higher porosity than plexiform bone [29,30], yet has higher compressive strength [25,30]. Furthermore, it has been recently argued that plexiform bone is remodelled into Haversian bone only in regions where the bone experiences high compressive stresses [25,31].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Splitting fracture in bovine bone using a porosity-based spring network model

Mayya

Praveen

Banerjee

et al. 2016

J. R. Soc. Interface.

Self Cite

View full text Add to dashboard Cite

We examine the specific role of the structure of the network of pores in plexiform bone in its fracture behaviour under compression. Computed tomography scan images of the sample pre-and post-compressive failure show the existence of weak planes formed by aligned thin long pores extending through the length. We show that the physics of the fracture process is captured by a two-dimensional random spring network model that reproduces well the macroscopic response and qualitative features of fracture paths obtained experimentally, as well as avalanche statistics seen in recent experiments on porcine bone.

show abstract

“…Moreover, in some bones of certain vertebrates, including the furcula of birds, Haversian bone tends to be localized in certain areas, which likely correspond to areas under higher strain. For instance, Mayya et al (2016) found that Haversian tissue formed only in regions under compressive strain in bovine femora, whereas regions withstanding tensile strains remained as primary tissue (Mayya et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Bone histological correlates of soaring and high-frequency flapping flight in the furculae of birds

Mitchell

Legendre

Lefèvre

et al. 2017

Zoology

View full text Add to dashboard Cite

The furcula is a specialized bone in birds involved in flight function. Its morphology has been shown to reflect different flight styles from soaring/gliding birds, subaqueous flight to high-frequency flapping flyers. The strain experienced by furculae can vary depending on flight type. Bone remodeling is a response to damage incurred from different strain magnitudes and types. In this study, we tested whether a bone microstructural feature, namely Haversian bone density, differs in birds with different flight styles, and reassessed previous work using phylogenetic comparative methods that assume an evolutionary model with additional taxa. We show that soaring birds have higher Haversian bone densities than birds with a flapping style of flight. This result is probably linked to the fact that the furculae of soaring birds provide less protraction force and more depression force than furculae of birds showing other kinds of flight. The whole bone area is another explanatory factor, which confirms the fact that size is an important consideration in Haversian bone development. All birds, however, display Haversian bone development in their furculae, and other factors like age could be affecting the response of Haversian bone development.

show abstract

Haversian microstructure in bovine femoral cortices: An adaptation for improved compressive strength

Cited by 25 publications

References 41 publications

H‐type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing

H‐type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing

Splitting fracture in bovine bone using a porosity-based spring network model

Bone histological correlates of soaring and high-frequency flapping flight in the furculae of birds

Contact Info

Product

Resources

About