Having small‐for‐gestational‐age infants was associated with maternal allergic features in the <scp>JECS</scp> birth cohort

Saito, Mari; Yamamoto‐Hanada, Kiwako; Pak, Kyongsun; Ayabe, Tadayuki; Mezawa, Hidetoshi; Ishitsuka, Kazue; Konishi, Mizuho; Yang, Limin; Matsumoto, Kenji; Saito, Hirohisa; Ohya, Yukihiro

doi:10.1111/all.13490

Cited by 13 publications

(15 citation statements)

References 10 publications

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“…A recent study of children reported associations of different blood lipids with the anti-inflammatory cytokine IL-10 and the proinflammatory cytokines IL-17 and IL-23. 11 Based on the results of this study, we speculate that the presence of a chronic inflammatory state, as indicated by dyslipidemia, affects the lower airway 2 and the nasal airway.…”

Section: Letters To the Editormentioning

confidence: 65%

“…10 Elevated TG and LDL-C lead to proinflammatory signaling and increased expression of TNF-a and interleukin (IL)-6. 10,11 In contrast, HDL-C has an anti-inflammatory effect, in that, it modulates T-cell activation 10,11 and may improve the olfactory threshold. A recent study of children reported associations of different blood lipids with the anti-inflammatory cytokine IL-10 and the proinflammatory cytokines IL-17 and IL-23.…”

Section: Letters To the Editormentioning

confidence: 99%

See 1 more Smart Citation

Serum lipid levels are associated with allergic rhinitis, nasal symptoms, peripheral olfactory function, and nasal airway patency in children

Yon

Lee

et al. 2018

Allergy

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Section: Letters To the Editormentioning

confidence: 65%

Section: Letters To the Editormentioning

confidence: 99%

Serum lipid levels are associated with allergic rhinitis, nasal symptoms, peripheral olfactory function, and nasal airway patency in children

Yon

Lee

et al. 2018

Allergy

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“…12 JECS is an ongoing cohort study conducted by the Ministry of the Environment, Japan. 13,14 A general population of 103,060 pregnant women was enrolled in the JECS in 15 study areas, covering a wide geographical area from the north of the country (Hokkaido) to the south (Okinawa), from January 2011 to March 2014. All participants within each of the 15 study areas were followed.…”

Section: Study Design Setting and Populationmentioning

confidence: 99%

Allergy and immunology in young children of Japan: The JECS cohort

Yamamoto‐Hanada

Pak

Saito‐Abe

et al. 2020

World Allergy Organization Journal

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Background: Capturing epidemiological signatures is essential to document burdens of disease and to design health care services, including prevention measures, clinical interventions, and policies. There are large geographical and ethnic variations in the epidemiology of allergic and immunological diseases. Various data are available from North America and Europe, but the epidemiology of allergic and immunological diseases in Asia is not well documented. Objective: To characterize epidemiological signatures of allergic and immunological disease in young children in Japan. Methods: This was a national, multicenter, prospective birth cohort study: Japan Environment and Children's Study (JECS). A general population of 103,060 women was enrolled during pregnancy. Allergic and immunological outcomes were assessed among young children using questionnaire data. Results: The prevalence of caregiver-reported immediate food allergy was 7.6%, 6.7%, and 4.9% at age 1, 2, and 3 years, respectively. Hen egg allergy was most common (5.4% prevalence at age 1 year) followed by allergies to cow milk and wheat. Several patterns of allergic symptom clusters were identified. Physician diagnosed, as reported by the caregiver, non-IgE mediated gastrointestinal food allergy affected 0.5% of infants. By contrast, caregiver-reported gastrointestinal food allergies affected 1.4% of children. Kawasaki disease affected 0.3% and 0.4% children, respectively, at age 1 and 3 years. Primary immunodeficiency disorders affected 0.005% children at age 3 years. Conclusion: These data provide important epidemiological signatures of allergy and immunology in young Japanese children including the age-specific prevalence of allergic disease, Kawasaki disease, and primary immune deficiency.

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“…Previous studies demonstrated that maternal asthma can affect adverse pregnancy outcomes such as preterm birth [2][3][4][5][6][7][8][9]. Our group also found that IgE production and a history of atopic dermatitis were positively associated with smallfor-gestational-age (SGA) births in a nationwide birth cohort study (Japan Environment and Children's Study: JECS) [10]. Based on these results, we hypothesized that immunological inflammations related to allergic diseases may affect the uterine environment and perinatal outcomes.…”

Section: Introductionmentioning

confidence: 66%

Association of Maternal History of Allergic Features with Preterm Pregnancy Outcomes in the Japan Environment and Children’s Study

Saito-Abe

Yamamoto‐Hanada

Pak

et al. 2021

Int Arch Allergy Immunol

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Introduction: Previous studies have reported that maternal asthma increases the risk of preterm birth. We hypothesized that inflammatory reactions caused by allergic diseases might affect the uterine environment and, subsequently, perinatal outcomes. The objective of this study was to examine the associations between allergic features among mothers and preterm pregnancy outcomes in a nationwide birth cohort. Methods: We analyzed data from pregnant women obtained from the Japanese Environment and Children’s Study (JECS), a nationwide general birth cohort study. We used binomial and multinomial logistic regression models to examine the associations between maternal allergic features and preterm birth, threatened preterm labor (TPL), and preterm premature rupture of the membrane (PPROM). Results: A total of 97,683 pregnant women were included. Prevalence of preterm birth, TPL, and PPROM was 4.7, 19.6, and 1.2%, respectively. Maternal history of allergic diseases (asthma, allergic rhinitis, allergic conjunctivitis, food allergy, drug allergy, and contact dermatitis) increased the risk of TPL(adjusted odds ratio [aOR] = 1.11 [95% CI: 1.06–1.17], aOR = 1.12 [1.08–1.16], aOR = 1.10 [1.04–1.16], aOR = 1.17 [1.09–1.26], aOR = 1.35 [1.23–1.48], and aOR = 1.34 [1.20–1.49], respectively). Although some maternal allergic features showed a negative association with preterm birth, the variables affecting preterm birth differed according to the gestational age of the fetus (22–33 weeks vs. 34–36 weeks). There were no significant associations between maternal allergic features and PPROM. Conclusion: Maternal allergic disease, except atopic dermatitis, may increase the risk of TPL. Comorbidity of maternal allergic disorders and perinatal adverse outcomes require further investigation.

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Having small‐for‐gestational‐age infants was associated with maternal allergic features in the JECS birth cohort

Cited by 13 publications

References 10 publications

Serum lipid levels are associated with allergic rhinitis, nasal symptoms, peripheral olfactory function, and nasal airway patency in children

Serum lipid levels are associated with allergic rhinitis, nasal symptoms, peripheral olfactory function, and nasal airway patency in children

Allergy and immunology in young children of Japan: The JECS cohort

Association of Maternal History of Allergic Features with Preterm Pregnancy Outcomes in the Japan Environment and Children’s Study

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