Hawthorn (Crataegus spp.) from botanical source to phytopreparations

Background: Cardiovascular disease remains a leading cause of mortality worldwide, necessitating advanced predictive models to improve early detection and prevention. The integration of natural remedies with machine learning techniques offers a promising approach for enhancing heart disease prediction. Aim: This study aims to develop a hybrid learning model for predicting cardiac disease by combining machine learning algorithms with natural remedies to improve the model’s accuracy and clinical applicability. Methods: A dataset titled “Indicators of Heart Disease (2022 UPDATE)” containing 246,023 patient records was sourced from Kaggle. The hybrid model combines Random Forest (RF) for interpretability and Long Short-Term Memory (LSTM) networks for time-series analysis. Features related to herbal medicines and their impact on heart health were incorporated to enhance predictive accuracy. Results: The hybrid model achieved an accuracy of 100%, demonstrating the potential of integrating traditional medical data with natural remedies to enhance cardiovascular disease forecasting. The inclusion of natural remedies provided a comprehensive tool for clinicians, enabling more precise decision-making. Conclusion: Integrating natural remedies into machine learning models is a promising direction for improving the prediction and early prevention of heart disease. This approach offers a sustainable and accessible solution to cardiovascular healthcare, with the potential to significantly improve patient outcomes.

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Comparative study between homemade and commercial hawthorn (Crataegus spp.) extracts regarding their phenolic profile and antioxidant activity

Zivanovic,

Simin,

Lesjak

et al. 2024

JSCS

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Crataegus species (hawthorn) have been commonly used in traditional medicine, especially for the treatment of congestive heart failure. Many studies confirmed that they are rich in polyphenols, thus exhibiting strong antioxidant activity, which contribute to the beneficial effects of hawthorn on the cardiovascular system. In the market, there are many herbal medicinal products based on hawthorn, which consumption as adjuvant therapy in heart-related issues is supported by European Medicines Agency. Since there is a global trend of making homemade herbal preparations, this study aimed to compare whether there is a difference in polyphenol profile and antioxidant potential between homemade and commercial ethanol extracts of hawthorn. Polyphenol profile was evaluated by determination of total phenolic and flavonoid contents, and by quantitative analysis of selected polyphenols by LC-MS/MS. Antioxidant potential was examined by DPPH, FRAP, and lipid peroxidation inhibition assays. The results of this study suggest that homemade ethanol extracts of hawthorn flowers, leaves and fruits are just as good source of polyphenols and antioxidants as commercial ones, and their utilization should be supported. Furthermore, hawthorn extracts made of leaves and flowers are better source of bioactive polyphenols and have higher antioxidant activity compared with the same of fruits, regardless of the method of preparation.

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Hawthorn (Crataegus spp.) from botanical source to phytopreparations

Cited by 4 publications

References 21 publications

Phytochemical Profiles and Biological Studies of Selected Botanical Dietary Supplements Used in the United States

Phytochemical Profiles and Biological Studies of Selected Botanical Dietary Supplements Used in the United States

Enhancing Heart Health Prediction with Natural Remedies Through Integration of Hybrid Deep Learning Models

Comparative study between homemade and commercial hawthorn (Crataegus spp.) extracts regarding their phenolic profile and antioxidant activity

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