2008
DOI: 10.1016/j.phrs.2008.05.001
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Hawthorn extract inhibits human isolated neutrophil functions

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Cited by 22 publications
(18 citation statements)
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“…These authors concluded that chemotaxis is decreased in isolated neutrophils from COPD patients versus healthy subjects and that the increased number of neutrophils in the airways of COPD patients may be related to the increase in neutrophil chemotactic factors in the lungs such as IL-8 or by the increase in adhesion molecules expression on pulmonary endothelial cells which is present in COPD patients [26,27,28]. In this work, we selected the Boyden chamber technique to measure neutrophil chemotaxis, since this is a well-experimented technique known for long by our group and others [18,19,29], and do not need to introduce nor manipulate cells with fluorescent dye incubations such as fluorescence calcein [26] which could modify neutrophil properties. In this line, there are few works that have studied peripheral blood chemotaxis in COPD patients versus healthy subjects, so discrepancy between previous observations and results shown in this study may be explained by different methods used to quantify chemotaxis and by differences in COPD patients, as the severe, early-onset patients in our study present a more advanced disease and therefore a possibly different neutrophil activation status.…”
Section: Discussionmentioning
confidence: 99%
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“…These authors concluded that chemotaxis is decreased in isolated neutrophils from COPD patients versus healthy subjects and that the increased number of neutrophils in the airways of COPD patients may be related to the increase in neutrophil chemotactic factors in the lungs such as IL-8 or by the increase in adhesion molecules expression on pulmonary endothelial cells which is present in COPD patients [26,27,28]. In this work, we selected the Boyden chamber technique to measure neutrophil chemotaxis, since this is a well-experimented technique known for long by our group and others [18,19,29], and do not need to introduce nor manipulate cells with fluorescent dye incubations such as fluorescence calcein [26] which could modify neutrophil properties. In this line, there are few works that have studied peripheral blood chemotaxis in COPD patients versus healthy subjects, so discrepancy between previous observations and results shown in this study may be explained by different methods used to quantify chemotaxis and by differences in COPD patients, as the severe, early-onset patients in our study present a more advanced disease and therefore a possibly different neutrophil activation status.…”
Section: Discussionmentioning
confidence: 99%
“…Neutrophils were isolated from peripheral venous blood by standard laboratory procedures [18]. In brief, peripheral venous blood was mixed with dextran 500 at 3% (in 0.9% saline) in a proportion of 2:1.…”
Section: Methodsmentioning
confidence: 99%
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“…Besides, hawthorn extract inhibited N-formyl-Met-Leu-Phe (FMLP-) induced superoxide anion generation, elastase release, and chemotactic migration and reduced leukotriene B4 production and lipopolysaccharide-induced generation of TNF- α and IL-8. Also the extract inhibited intracellular calcium signal and the extracellular calcium entry into calcium-depleted neutrophils [38]. Moreover, the anti-inflammatory mechanism also illustrated that the activity of triterpene fraction isolated from Crataegus was closely related to inhibition of peritoneal leukocyte infiltration and weak inhibition of phospholipase A2 (PLA2) in vitro [39].…”
Section: Cardiovascular Effectmentioning
confidence: 99%
“…Crataegus leaves, a traditional herbal medicine, has been widely used in European countries for the treatment of cardiovascular diseases (Chatterjee, Koch, Jaggy, & Krzeminski, 1997;Pittler, Schmidt, & Ernst, 2003;Rigelsky & Sweet, 2002), such as congestive heart failure, high blood pressure, hypoxia and hyperlipemia (Çelebi Koçyõldõz et al, 2006;Dalli et al, 2008;Leuchtgens, 1993;Weikl et al, 1996). Crataegus is divided into various species, including Crataegus pinnatifida Bge.…”
Section: Introductionmentioning
confidence: 99%