Seismic activity poses significant challenges to urban infrastructure, often resulting in road closures due to the combined effects of damaged buildings and road networks. This study proposes a novel methodological approach to improve the understanding of such vulnerabilities by introducing a comprehensive analysis of the vulnerability index within a fuzzy multi-criteria framework for transport networks by integrating various criteria. The proposed methodology incorporates both quantitative and qualitative factors, providing a holistic view of the complex relationships between damaged buildings, infrastructure and transport networks. To validate the effectiveness of the methodology, a case study is conducted in a highly populated urban area in Istanbul where an earthquake risk is encountered. proposed methodology is applied to this study area and the results are demonstrated and discussed. The results demonstrate the ability of the approach to identify and quantify vulnerabilities within the transport network, aiding in the identification of high-risk areas which will lead to which will lead to necessary mitigation measures mitigation measures. Ultimately, this research contributes to a more resilient urban infrastructure by providing a structured and comprehensive vulnerability analysis that takes into account the complex interactions between damaged buildings, road networks and disaster response mechanisms.