Background: Supply chain includes all related parts that directly or indirectly meet the customers’ demands. During disasters, the supply chain disrupts. It seems that paying attention to innovation and entrepreneurship can solve some of these disruptions. This study was conducted to extract the factors affecting the technology-oriented entrepreneurial rescue supply chain in the Red Crescent Society from experts and specialists in Iran. Materials and Methods: This qualitative content analysis was conducted in 2020. Using the content analysis method, the considered criteria were collected through open-ended questions and interviews. To determine the desired indicators, 30 people were interviewed in-depth in a purposeful manner using snowball sampling. The thematic analysis method was also used to analyze the interviews. Results: A total of 30 experts with a mean age of 46 years were interviewed, of whom 21 cases were male. Also, 16 cases had a PhD degree, and 14 had a Master’s degree. After analyzing and extracting the criteria from the interviews, 123 codes were obtained. Finally, the codes were divided into two classes: supply chain management and technology indicators. The supply chain management class included subclasses of customer integration, supplier integration, internal integration, and innovative orientation. The technology indicators class included subclasses of individual characteristics, attitudinal factors, educational factors, technical factors, economic factors, environmental factors, and human and managerial factors. Conclusion: Supply chains are essential for entrepreneurship because of the involvement of different parts of the Red Crescent Organization of Iran in joint activities. Because of the expansion of entrepreneurship issues in the supply chain, presenting a technology-oriented comprehensive model of the entrepreneurial supply chain in the Red Crescent Organization is of great importance. In today’s competitive environment, supply chain management is a strategic and robust basis for the Red Crescent Organization to achieve success and competitive advantage.