Hazardous impact of diclofenac on mammalian system: Mitigation strategy through green remediation approach

Sathishkumar, Palanivel; Mohan, Kiran; Meena, Ramakrishnan Anu Alias; Balasubramanian, Murugesan; Loganathan, Chitra; Ganesan, Abirami Ramu; Palvannan, Thayumanavan; Brar, Satinder Kaur; Gu, Feng

doi:10.1016/j.jhazmat.2021.126135

Cited by 44 publications

(9 citation statements)

References 186 publications

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“…[4,5] Nowadays, its use is increasing due to the palliative care needed by the aging population, and it is reported that its annual consumption reaches 2400 tons in the world and is considered one of the most destructive micropollutants in the environment. [6] It has been stated that DCF has the highest acute toxicity in its anti-inflammatory and analgesic class and may cause a decrease in fish and bird populations by causing kidney failure. [7] The excretion of DCF from the metabolism is accomplished by its conjugation with glucuronic acid and sulfate.…”

Section: Introductionmentioning

confidence: 99%

“…Since kidney functions are generally COX-dependent drugs such as DCF that exert their effect through COX inhibition can cause nephrotoxicity. [6] Inhibition of the synthesis of prostaglandins by the use of DCF leads to impaired renal function, decreased glomerular hydrostatic pressure, and ultimately acute kidney injury. [9] The mechanism of indirect DCF toxicity is explained by increased oxidative stress and mitochondrial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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The effect of tyrosol on diclofenac sodium‐induced acute nephrotoxicity in rats

Çömez,

Cellat,

Kuzu

et al. 2023

J Biochem & Molecular Tox

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Although diclofenac (DCF) is a nonsteroidal anti‐inflammatory drug that is considered safe, its chronic use and overdose may show some toxic effects. The protective effect of tyrosol (Tyr) pretreatment against DCF‐induced renal damage was investigated in this study. The 32 rats used in the study were randomly divided into four groups of eight rats each. According to the data obtained, it was determined that creatinine, urea, and blood urea nitrogen (BUN) levels increased in serum samples of the DCF group. Besides, the levels of reduced glutathione (GSH) and glutathione peroxidase (GPx) activity decreased and the malondialdehyde (MDA) level increased in the kidney tissue. However, no change was observed in catalase (CAT) activity. Cyclooxygenase‐2 (COX‐2), nuclear factor kappa B (NF‐κB), and tumor necrosis factor‐alpha (Tnf‐α) levels increased and nuclear factor erythroid 2‐related factor 2 (Nrf‐2) levels decreased. No change was detected in the level of interleukin 1 beta (IL‐1β). When the DCF+Tyr group and the DCF group were compared, it was assessed that Tyr had a curative effect on all biochemical parameters. Also, kidney damages, such as degeneration and necrosis of tubular epithelium and congestion of veins, were obviated by treatment with tyrosol in histopathological examinations. It was determined that Tyr pretreatment provided a protective effect against nephrotoxicity induced by DCF with its anti‐inflammatory and antioxidant properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of tyrosol on diclofenac sodium‐induced acute nephrotoxicity in rats

Çömez,

Cellat,

Kuzu

et al. 2023

J Biochem & Molecular Tox

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“…As arthritis and heart diseases have become more typical for an aging society, diclofenac usage is expanding. As a result, the diclofenac market has grown substantially, with its expected revenue up to $5.64 billion in 2025. , Consequently, diclofenac contamination has been observed in several water sources, including river, groundwater, drinking water, hospital effluents, and sewage water . Although the diclofenac contamination is low, it can cause acute toxic effects to many organisms in water, like mussels, and can lead to chronic toxicological effects with extended exposure .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, a diclofenac molecule can transform into a diclofenac ion by sunlight. The ion reactions with other contaminants in water lead to other forms of more toxic substances. , Therefore, diclofenac should not be released into the environment, especially water resources.…”

Section: Introductionmentioning

confidence: 99%

“…6 Although the diclofenac contamination is low, it can cause acute toxic effects to many organisms in water, like mussels, and can lead to chronic toxicological effects with extended exposure. 2 Moreover, a diclofenac molecule can transform into a diclofenac ion by sunlight. The ion reactions with other contaminants in water lead to other forms of more toxic substances.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of a Magnetic Carbon Nanofiber Derived from Bacterial Cellulose for the Removal of Diclofenac from Water

et al. 2022

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Engineering and synthesis of novel materials are vital for removing emerging pollutants, such as pharmaceuticals from contaminated water. In this study, a magnetic carbon nanofiber (MCF) fabricated from bacterial cellulose was tested for the adsorption of diclofenac from water. The physical and chemical properties of the synthesized adsorbent were examined by field emission scanning electron microscopy (FESEM), field emission transmission electron microscopy (FETEM), X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET) analysis, energy-dispersive X-ray spectroscopy (EDS), a vibrating sample magnetometer (VSM), Raman spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. The characterization results showed that the MCF is a carbon nanofiber with a three-dimensional interconnect network, forming a porous material (mesopores and macropores) with a specific surface area of 222.3 m2/g. The removal of diclofenac (10 mg/L) by the MCF (0.75 g/L) was efficient (93.2%) and fast (in 20 min). According to the Langmuir isotherm model fitting, the maximum adsorption capacity of the MCF was 43.56 mg/g. Moreover, continuous adsorption of diclofenac onto MCF was investigated in a fixed-bed column, and the maximum adsorption capacity was found to be 67 mg/g. The finding of this research revealed that the MCF could be a promising adsorbent used to remove diclofenac from water, while it can be easily recovered by magnetic separation.

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Methodologies for the Detection and Remediation of Organic Micropollutants in Terrestrial Ecosystems

Randhawa

2024

Organic Micropollutants in Aquatic and Terrestrial Environments

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Hazardous impact of diclofenac on mammalian system: Mitigation strategy through green remediation approach

Cited by 44 publications

References 186 publications

The effect of tyrosol on diclofenac sodium‐induced acute nephrotoxicity in rats

The effect of tyrosol on diclofenac sodium‐induced acute nephrotoxicity in rats

Synthesis and Characterization of a Magnetic Carbon Nanofiber Derived from Bacterial Cellulose for the Removal of Diclofenac from Water

Methodologies for the Detection and Remediation of Organic Micropollutants in Terrestrial Ecosystems

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