Environmental cleanup may involve decontaminating an area affected by a radiological release, containing an oil spill, or remediating a Superfund site or brownfield. It is a key component of how environmental agencies work to protect public health and the environment. There are many publications on technical protocols for cleanup and waste disposal. Additionally, there has been much social science work on the social problems of environmental contamination. However, social science research on cleanup itself has been much more scattered across disciplines and incidents. To date, there has not been a comprehensive review of the social factors that affect cleanup processes and outcomes. Such social factors may include cultural worldviews that shape stakeholder perspectives on 'how clean is clean' and social relationships among stakeholders. This article fills this gap by providing an interdisciplinary literature review of the social science of environmental cleanup. Three principal themes emerged from the 97 articles that met selection criteria: effects on cleanup worker health, public engagement and decision-making, and societal benefits of cleaned-up sites. The review points to areas where further research is needed. For example, there is a lack of mixed methods and interdisciplinary engagement within the literature. Additionally, few articles compare cleanup situations. There is also a need for further investigation into specific social science topics such as labor practices, gender, race, and power relationships. To address these gaps, we argue for the development of a comprehensive framework or model as well as the exploration of broader questions complicating cleanups. Overall, this area of research has significant potential to benefit environmental cleanup policy and practice worldwide, while advancing social theory about people and the environment.