HB Andrew-Minneapolis [β144(HC1)LYS→ASN] in a German Family from Berlin

Identification of high oxygen affinity hemoglobin (Hb Andrew‐Minneapolis) in an Indian family

“…It was first described in a 37-year-old male form Minneapolis, USA, by Zak et al in 1973 [2]. Till date, various cases of Hb Andrew-Minneapolis have been reported and majority of the cases were reported adults in heterozygous form [3][4][5][6][7]. Here, we report the first case of Hb Andrew-Minneapolis in homozygous form in an Indian family.…”

“…As reported earlier, Hb Andrew-Minneapolis is transmitted as an autosomal dominant trait and hence it expressed clinically in the heterozygous condition. Hb Andrew-Minneapolis in the heterozygous form was known to cause remarkable erythrocytosis and hyperviscosity syndrome as previously described [3][4][5][6][7].…”

Hemoglobin Andrew-Minneapolis: Hemolytic Erythrocytosis and Severe Iron Overload in Toxic Liver Cirrhosis

“…This results in a left shift of the Hb-oxygen dissociation curve and consecutive erythrocytosis [1]. Only limited reports of falsely high HbA1c levels exist [2, 3]. We suspect that our patient had falsely low HbA1c levels because fasting glucose values were repeatedly >200 mg/dL, and daily blood glucose levels were always pathologically high.…”

“…Misjudgements of the patient's type 2 diabetes were due to falsely low results of HbA1c levels. Interestingly, only falsely high HbA1c levels have been reported [2, 3]. …”

Carnivora: The Primary Structure of the α-Chains of Ferret (Mustela putorius furo,Mustelidae) Hemoglobins

“…In the Mustelinae, we have previously described the sequence of the -chain^ common to the two hemoglobins of the ferret (Mustela putorius furo), a polecat which has been domesticated at least since Roman times^. In this paper, the full sequences of the two different achains from the hemoglobins of the ferret are presented, together with a phylogenetic discussion, and compared to the recently sequenced corresponding chains of the adult European polecat [11] , the wild strain the ferret may originate from.…”