Hb D-Iran [β22(B4)6Lu↠6Ln] in Southern Italy

Compound heterozygosity of Hb DIran (β22 Glu→Gln) and β0‐thalassemia (619 bp‐deletion) in India

“…Hb D Iran (β 22 Glu→Gln) is one such β‐chain variant that was first described by Rahbar (1973) in the members of Iranian family. Hb D Iran is found in Iranian and Pakistani families, a Jamaican Black, Indian and several families in Italy (2–4).…”

Compound heterozygote of Hb DIran [HBB: c.67G>C, β 22(B4) Glu>Gln] with β0-thalassemia [cds 41/42 (-CTTT)] from Eastern India

“…The Hb D Iran trait and homozygous cases have been reported earlier. 4 , 5 However, few studies have reported compound heterozygotes of Hb D Iran with other Hb variants like Hb S and Hb D Punjab , β + -thalassemia IVS1–5 (G>C), β 0 -thalassemia (619 bp-deletion) and undefined β-thalassemia from India and Pakistan. Various studies have reported that the quantity of Hb D Iran eluting in the Hb A 2 window in HPLC varies from 36.0 to 47.7% in a heterozygous condition, while in compound heterozygous states, the quantity varies between 47.3 and 94.4% (with Hb D Punjab , Hb S, β-thalassemia with the 619 bp deletion mutation and beta thalassemia with unknown mutation).…”