HB old Dominion/Burton-upon-Trent or β143(H2l)His→TYR, Found in a Diabetic Woman from Korea

The number of unexpected HbA1c variants may be a greater problem in routine practice than is generally realized

“…The variant haemoglobin was found to be due to a point mutation CAC → TAC of codon 143 of the beta chain and was subsequently published simultaneously by two groups [12,13] and later named Hb Old Dominion/Burton‐on‐Trent [β143 (H21) His → Tyr][14]. Since these initial reports of four individuals from three families, all of whom had an Irish element in their ancestry, two further Anglo‐Celtic cases [15] and one Korean case [16] have been described.…”