HBCD and TBBPA in human scalp hair: Evidence of internal exposure

Barghi, Mandana; Shin, Eun-su; Choi, Sung-Deuk; Behrooz, Reza Dahmardeh; Chang, Yoon Seok

doi:10.1016/j.chemosphere.2018.05.032

Cited by 53 publications

(12 citation statements)

References 33 publications

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“…In a designed exposure experiment reported by Kucharska et al, 50 PBDEs and OPFRs with lower vapor pressure had lower transfer efficiencies from the gaseous phase to hair. Barghi et al 51 found that the concentrations of HBCD and TBBPA in hair samples showed no increase after a oneweek gaseous phase exposure experiment due to their lower vapor pressure. The OPFR or PBDE congeners varied much in vapor pressure (0.0000629−0.46 for OPFRs; 6.23 × 10 −10 − 0.000144 for PBDEs), which might be the reason why their accumulation rates were not associated significantly with log vapor pressure, revealing that the accumulation of PBDEs and OPFRs along the hair shaft was more complicated than that of PCBs.…”

Section: Environmental Science and Technologymentioning

confidence: 99%

Legacy and Currently Used Organic Contaminants in Human Hair and Hand Wipes of Female E-Waste Dismantling Workers and Workplace Dust in South China

Qiao

Zheng

et al. 2019

Environ. Sci. Technol.

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Legacy organic contaminants, such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), and several currently used organic contaminants, such as novel brominated retardants (NBFRs), organophosphate flame retardants (OPFRs), and Dechlorane Plus (DPs), were measured in the segmented hair and hand wipes of e-waste dismantling workers and in the dust from their workplace in an e-waste recycling site in South China to assess the accumulation and sources of organic contaminants in the hair shaft. The median concentrations of DPs, PBDEs, NBFRs, PCBs and OPFRs in hair samples were 23.5, 154, 156, 349, and 371 ng/g, respectively. A linear increase in organic contaminant concentrations was found along the hair shaft, with significant differences among each segment, while the age-related patterns were similar among the 7 hair segments. A linear relationship was found between the accumulation rates and the log K OW, indicating that the accumulation rates of organic contaminants along the hair shaft decreased with increasing log K OW values. Enantiomer fraction (EF) values of PCB-132 in distal segments were close to those in dust and air, while EFs in proximal segments were close to those in serum. The contributions of PCBs from external sources to hair increased with the distance from the scalp of hair segments, from 67.8% in 0−3 cm segments to 95.9% in 18−21 cm segments.

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Section: Environmental Science and Technologymentioning

confidence: 99%

Legacy and Currently Used Organic Contaminants in Human Hair and Hand Wipes of Female E-Waste Dismantling Workers and Workplace Dust in South China

Qiao

Zheng

et al. 2019

Environ. Sci. Technol.

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“…The authors did not find any association between the levels of HBCDDs measured in human milk and hair samples. Barghi et al (2018) analysed human scalp hair for HBCDDs in samples from South Korea and Iran. The concentrations for ΣHBCDDs in the collected hair samples ranged from < LOD (0.04-0.09 ng/g) to 3.24 ng/g with a mean of 0.46 ng/g hair.…”

Section: Other Human Tissuesmentioning

confidence: 99%

“…Barghi et al. (2018) analysed human scalp hair for HBCDDs in samples from South Korea and Iran. The concentrations for ΣHBCDDs in the collected hair samples ranged from < LOD (0.04–0.09 ng/g) to 3.24 ng/g with a mean of 0.46 ng/g hair.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food

Schrenk

Bignami

Bodin³

et al. 2021

EFS2

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The European Commission asked EFSA to update its 2011 risk assessment on hexabromocyclododecanes ( HBCDD s) in food. HBCDD s, predominantly mixtures of the stereoisomers α‐, β‐ and γ‐ HBCDD , were widely used additive flame retardants. Concern has been raised because of the occurrence of HBCDD s in the environment, food and in humans. Main targets for toxicity are neurodevelopment, the liver, thyroid hormone homeostasis and the reproductive and immune systems. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour in mice can be considered the critical effects. Based on effects on spontaneous behaviour in mice, the Panel identified a lowest observed adverse effect level ( LOAEL ) of 0.9 mg/kg body weight (bw) as the Reference Point, corresponding to a body burden of 0.75 mg/kg bw. The chronic intake that would lead to the same body burden in humans was calculated to be 2.35 μg/kg bw per day. The derivation of a health‐based guidance value ( HBGV ) was not considered appropriate. Instead, the margin of exposure ( MOE ) approach was applied to assess possible health concerns. Over 6,000 analytical results for HBCDD s in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary LB exposure to HBCDD s were fish meat, eggs, livestock meat and poultry. The CONTAM Panel concluded that the resulting MOE values support the conclusion that current dietary exposure to HBCDD s across European countries does not raise a health concern. An exception is breastfed infants with high milk consumption, for which the lowest MOE values may raise a health concern.

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“…Tetrabromobisphenol A (TBBPA) is among the most commonly used brominated flame retardants owing to its excellent properties and low price, and its annual application is continually increasing. , The high detection frequency in various environmental media − makes the behavior and environmental fate of TBBPA still an important issue and focal point in environmental science.…”

Section: Introductionmentioning

confidence: 99%

Two Typical Glycosylated Metabolites of Tetrabromobisphenol A Formed in Plants: Excretion and Deglycosylation in Plant Root Zones

Hou

Wei

Tang

et al. 2021

Environ. Sci. Technol. Lett.

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The glycosylation process was investigated for the common brominated flame retardant tetrabromobisphenol A (TBBPA) in hydroponic exposure systems with pumpkin seedlings. Two typical glycosylation metabolites of TBBPA formed in pumpkin seedlings, TBBPA mono-β-d-glucopyranoside (TBBPA MG) and TBBPA di-β-d-glucopyranoside (TBBPA DG), increasing their mass early in the exposure (reaching maximum masses of 608 ± 53 and 3806 ± 1570 pmol at 12 h, respectively) and then falling throughout exposure. These two metabolites were released from roots to rhizosphere solutions, where they also exhibited initial increases followed by decreasing trends (reaching maximum masses of 595 ± 272 pmol at 3 h and 77.1 ± 36.0 pmol at 6 h, respectively). However, a (pseudo)zero-order deglycosylation of TBBPA MG and TBBPA DG (during the first 1.5 h) back to TBBPA was unexpectedly detected in the hydroponic solutions containing pumpkin exudates and microorganisms. The function of microorganisms in the solutions was further investigated, revealing that the microorganisms were main contributors to deglycosylation. Plant detoxification through glycosylation and excretion, followed by deglycosylation of metabolites back to the toxic parent compound (TBBPA) in hydroponic solutions, provides new insight into the uptake, transformation, and environmental fate of TBBPA and its glycosylated metabolites in plant/microbial systems.

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HBCD and TBBPA in human scalp hair: Evidence of internal exposure

Cited by 53 publications

References 33 publications

Legacy and Currently Used Organic Contaminants in Human Hair and Hand Wipes of Female E-Waste Dismantling Workers and Workplace Dust in South China

Legacy and Currently Used Organic Contaminants in Human Hair and Hand Wipes of Female E-Waste Dismantling Workers and Workplace Dust in South China

Update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food

Two Typical Glycosylated Metabolites of Tetrabromobisphenol A Formed in Plants: Excretion and Deglycosylation in Plant Root Zones

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