2009
DOI: 10.1111/j.1537-2995.2009.02235.x
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HBOC‐201 use in traumatic brain injury: case report and review of literature

Abstract: Major HBOC trials to date have excluded severe TBI. We report the first use of an HBOC in severe TBI to correct profound anemia. The HBOC-201 rapidly corrected cerebral venous and central venous oxygen saturations. The patient's death may have been due to massive reperfusion injury from delayed repayment of cerebral oxygen debt in a severely ischemic brain.

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Cited by 18 publications
(14 citation statements)
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“…Recently, there have been two glutaraldehyde PolyHbs which have undergone phase III clinical trials. Hemopure® (HBOC-201) (Biopure Corp., Cambridge, MA) consists of polymerized bovine hemoglobin with a P 50 of 38 mm Hg and MW ranging from 130-500 kDa[13, 36-38]. In contrast, PolyHeme® (Northfield Laboratories Inc., Evanston, IL) consists of a pyridoxylated polymerized human hemoglobin with a P 50 of 28-30 mm Hg and a MW ranging from 128-400 kDa [14, 39, 40].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, there have been two glutaraldehyde PolyHbs which have undergone phase III clinical trials. Hemopure® (HBOC-201) (Biopure Corp., Cambridge, MA) consists of polymerized bovine hemoglobin with a P 50 of 38 mm Hg and MW ranging from 130-500 kDa[13, 36-38]. In contrast, PolyHeme® (Northfield Laboratories Inc., Evanston, IL) consists of a pyridoxylated polymerized human hemoglobin with a P 50 of 28-30 mm Hg and a MW ranging from 128-400 kDa [14, 39, 40].…”
Section: Introductionmentioning
confidence: 99%
“…Hemoglobin-based oxygen carriers were developed in response to the infectious issues associated with donor RBC and in an attempt to come up with an alternative treatment in those situations where RBC transfusion was not an option. The first generation of these products was known to cause renal toxicity and coagulopathy (3,4). HBOC-201 is a second generation HBOC that is a cellfree, stroma-free, polymerized version of bovine hemoglobin.…”
Section: Discussionmentioning
confidence: 99%
“…O 2 affinity) of 38 mm Hg and average MW of 250 kDa with < 2% α 2 β 2 . 14, 125-127 In contrast, PolyHeme®(Northfield Laboratories Inc., Evanston, IL) consists of a pyridoxylated polymerized human Hb with a P 50 of 28 - 30 mm Hg, and average MW of 150 kDa with < 1% α 2 β 2 . 12, 128-129 These PolyHbs were commercially developed, however hypertension and safety and toxicity issues attributed to vasoactivity and oxidative events 130 were critical impediments for their further clinical use in the U.S. 131-132 …”
Section: Oxygen Carrying Plasma Expandersmentioning
confidence: 99%