2010
DOI: 10.1007/s11901-010-0054-2
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HBV Drug Resistance Development, Testing, and Prevention

Abstract: Chronic infection by hepatitis B virus (HBV) can result in cirrhosis, hepatic failure, and hepatocellular carcinoma (HCC) if left untreated. The extent of liver injury and the risk of HCC closely correlate with active viral replication, as indicated by high levels of circulating HBV DNA. Five oral antiviral agents, each targeting the viral DNA polymerase, are currently available in the United States to inhibit viral replication. Their effective use requires proper monitoring of drug resistance development. The… Show more

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“…HBV replication lacks proofreading (21,23), and thus mutant viruses are produced as a result of replication errors. Consequently, in any given individual the virus exists as a mixed population, though the mutant (often defective) viruses tend to be a minor fraction.…”
Section: Discussionmentioning
confidence: 99%
“…HBV replication lacks proofreading (21,23), and thus mutant viruses are produced as a result of replication errors. Consequently, in any given individual the virus exists as a mixed population, though the mutant (often defective) viruses tend to be a minor fraction.…”
Section: Discussionmentioning
confidence: 99%