HBV Infection Status and the Risk of Cholangiocarcinoma in Asia: A Meta-Analysis

Zhang, Hao; Zhu, Biqing; He, Zhao; Liang, Jianxin; Zeng, Wenting

doi:10.1155/2016/3417976

Cited by 35 publications

(32 citation statements)

References 54 publications

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“…The association between HBV and iCCA has been also confirmed in another study, where an OR = 5.10 (95% CI 2.91‐8.95) was reported . More recently, a meta‐analysis including 39 studies reported an OR = 2.72 (95% CI 1.90‐3.88) for the risk of CCA in HBV positive patients; in particular, an OR = 3.184 (95% CI 2.356‐4.302) was found for iCCA, whereas a weak association was found for eCCA (OR = 1.407, 95% CI 0.925‐2.141) …”

Section: Risk Factorsmentioning

confidence: 55%

Cholangiocarcinoma: Epidemiology and risk factors

Khan

Tavolari

Brandi

2019

Liver International

534

495

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Cholangiocarcinoma (CCA) is a heterogeneous disease arising from a complex interaction between host‐specific genetic background and multiple risk factors. Globally, CCA incidence rates exhibit geographical variation, with much higher incidence in parts of the Eastern world compared to the West. These differences are likely to reflect differences in geographical risk factors as well as genetic determinants. Of note, over the past few decades, the incidence rates of CCA appear to change and subtypes of CCA appear to show distinct epidemiological trends. These trends need to be interpreted with caution given the issues of diagnosis, recording and coding of subtypes of CCA. Epidemiological evidences suggest that in general population some risk factors are less frequent but associated with a higher CCA risk, while others are more common but associated with a lower risk. Moreover, while some risk factors are shared by intrahepatic and both extrahepatic forms, others seem more specific for one of the two forms. Currently some pathological conditions have been clearly associated with CCA development, and other conditions are emerging; however, while their impact in increasing CCA risk as single etiological factors has been provided in many studies, less is known when two or more risk factors co‐occur in the same patient. Moreover, despite the advancements in the knowledge of CCA aetiology, in Western countries about 50% of cases are still diagnosed without any identifiable risk factor. It is therefore conceivable that other still undefined etiologic factors are responsible for the recent increase of CCA (especially iCCA) incidence worldwide.

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Section: Risk Factorsmentioning

confidence: 55%

Cholangiocarcinoma: Epidemiology and risk factors

Khan

Tavolari

Brandi

2019

Liver International

534

495

View full text Add to dashboard Cite

show abstract

“…Asian countries) [79,80] . The range of the OR in the HbsAg positive subjects goes from 2.3 to 9.7 [ Table 1] [81] . The presence of cirrhosis increases the risk of CCA [ Table 1] even more by 2.5 fold (95% CI: 1.2-5.1; P = 0.02) in HBV, and 3.2 fold (95% CI: 1.231-8.148, P = 0.017) in HCV patients [41] .…”

Section: Multiple Risk Factors Reveal Icca Subtype-specific Pathogenesismentioning

confidence: 99%

“…The burden of HCV in the last decades has been associated with the specific increase of the iCCA as well as the HCC [81] . Accordingly, clinical and pathological observations suggested that liver cirrhosis is specifically Table 1.…”

Section: Multiple Risk Factors Reveal Icca Subtype-specific Pathogenesismentioning

confidence: 99%

Intrahepatic cholangiocarcinoma: review and update

Cardinale¹,

Bragazzi²,

Carpino³

et al. 2018

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Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies that could develop at any level from the biliary tree. CCA is currently classified into intrahepatic (iCCA), perihilar and distal on the basis of its anatomical location. Of note, these three CCA subtypes have common features but also important inter-tumor and intra-tumor differences that can affect the pathogenesis and outcome. A unique feature of iCCA is that it recognizes as origin tissues, the hepatic parenchyma or large intrahepatic and extrahepatic bile ducts, which are furnished by two distinct stem cell niches, the canals of Hering and the peribiliary glands, respectively. The complexity of iCCA pathogenesis highlights the need of a multidisciplinary, translational and systemic approach to this malignancy. This review will focus on the advances of iCCA epidemiology, histo-morphology, risk factors, molecular pathogenesis, revealing the existence of multiple subsets of iCCA.

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“…HBV infection has been identified to be a risk factor for the incidence of ICC for a decade 9 - 11 . Subsequently, several studies have evaluated association between HBV infection and prognosis of ICC 12 - 19 .…”

Section: Discussionmentioning

confidence: 99%

Transarterial Chemoembolization: A Favorable Postoperative Management to Improve Prognosis of Hepatitis B Virus-associated Intrahepatic Cholangiocarcinoma after Surgical Resection

Jeong¹,

Zheng²,

Wang³

et al. 2017

Int. J. Biol. Sci.

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Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC).Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were enrolled. Prognostic impact of the clinicopathological factors as well as postoperative TACE were evaluated. Computed tomography findings of HBV-associated ICC were assessed.Results: Tumor size of larger than 5 cm (hazard ratio [HR], 5.654; 95% confidence interval [CI], 1.175 to 27.204; P = 0.031), postoperative TACE (HR, 0.123; 95% CI, 0.023 to 0.643; P = 0.013), and lymph node metastasis (HR, 3.284; 95% CI, 1.236 to 8.724; P = 0.017) revealed to be independently associated with survival outcomes of patients with HBV-associated ICC. Application of TACE, as a postoperative management to control early local recurrence on the basis of hepatic arterial phase enhancement, significantly prolonged survival outcomes (1-yr, 88.9%; 3-yr, 77.8%; 5-yr, 66.7%), compared to the patients who did not receive TACE (1-yr, 63.6%; 3-yr, 30.8%; 5-yr, 13.0%). When analyzed according to the status of hepatic arterial phase, arterial phase enhancement demonstrated a favorable trend on prognosis of patients with HBV-associated ICC without statistical significance (HR, 0.435; 95% CI, 0.140 to 1.359; P = 0.141), and TACE independently improved overall survival of patients with arterial phase enhancement (HR, 0.105; 95% CI, 0.014 to 0.774; P = 0.027).Conclusions: Put together, our results indicate that postoperative TACE effectively improves prognosis of HBV-associated ICC with arterial phase enhancement in CT scans. Large-sized trials are required for our results to be applied in clinical medicine.

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HBV Infection Status and the Risk of Cholangiocarcinoma in Asia: A Meta-Analysis

Cited by 35 publications

References 54 publications

Cholangiocarcinoma: Epidemiology and risk factors

Cholangiocarcinoma: Epidemiology and risk factors

Intrahepatic cholangiocarcinoma: review and update

Transarterial Chemoembolization: A Favorable Postoperative Management to Improve Prognosis of Hepatitis B Virus-associated Intrahepatic Cholangiocarcinoma after Surgical Resection

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