HBV viremia in newborns of HBsAg(+) predominantly Caucasian HBeAg(−) mothers

Papaevangelou, Vassiliki; Paraskevis, Dimitrios; Anastassiadou, Vassiliki; Stratiki, Evangelia; Machaira, Maria; Pitsouli, Irene; Haida, C.; Drakakis, P.; Stamouli, K.; Antsaklis, Aris; Hatzakis, Angelos

doi:10.1016/j.jcv.2010.11.009

Cited by 13 publications

(11 citation statements)

References 31 publications

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“…Wang et al [9] also indicated no significant effects of delivery mode on the prevention of mother-to-child transmission of HBV. Recently, using highly sensitive real-time PCR, Papaevangelou et al [18] reported that HBV DNA in peripheral blood of newborns was more often detected than HBsAg, however, no difference in the incidence of neonatal viremia was observed between the babies born by ECS and VD (21.9% vs. 26.5%, p = 0.685). Our data in the present study are in accordance with these reported results.…”

Section: Discussionmentioning

confidence: 99%

Effect of elective cesarean section on the risk of mother-to-child transmission of hepatitis B virus

Chen

Wen

et al. 2013

BMC Pregnancy Childbirth

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BackgroundMany clinicians and hepatitis B virus (HBV)-infected pregnant women prefer elective caesarean section (ECS) to prevent mother-to-child transmission of HBV, since some studies found higher transmission of HBV in infants born by vaginal delivery (VD) than by cesarean section. However, other studies showed that ECS does not reduce the risk of being infected with HBV in infants. In this study, we aimed to clarify whether ECS may reduce the risk of mother-to-child transmission of HBV.MethodsTotally 546 children (1–7-year-old) born to 544 HBsAg-positive mothers from 15 cities and rural areas across Jiangsu Province, China, were enrolled. Of these children, 137 (2 pairs of twins) were born to HBeAg-positive mothers; 285 were delivered by ECS and 261 others by VD (one pair of twin in each group). HBV serologic markers were tested by enzyme or microparticle immunoassay.ResultsThe maternal and gestational ages, maternal HBeAg-positive rates, and children’s ages, gender ratios, hepatitis B vaccine coverage and administrations of HBIG were comparable between ECS and VD groups (all p >0.05). The overall prevalence of HBsAg in the 546 children was 2.4%, with 2.5% (7/285) and 2.3% (6/261) in those born by ECS and VD respectively (p = 0.904). Further comparison of chronic HBV infection in the 137 children of HBeAg-positive mothers showed that the HBsAg-positive rates in ECS and VD groups were 10.3% (7/68) and 8.7% (6/69) respectively (p = 0.750), while the mothers had similar HBV DNA levels (2.38 × 106 vs. 2.35 × 106 IU/ml, p = 0.586). Additionally, the overall rate of anti-HBs ≥10 mIU/ml in the children was 71.6%, with 72.3% and 70.9% in those born by ECS and VD respectively (p = 0.717).ConclusionsWith the recommended immunoprophylaxis against hepatitis B, ECS does not reduce the risk of mother-to-child transmission of HBV. Therefore, ECS should not be used in HBsAg-positive pregnant women to prevent mother-to-child transmission of HBV.

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Section: Discussionmentioning

confidence: 99%

Effect of elective cesarean section on the risk of mother-to-child transmission of hepatitis B virus

Chen

Wen

et al. 2013

BMC Pregnancy Childbirth

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“…It is recommended that infants born to HBsAg carrier mothers should be tested for HBsAg and antiHBs at age 9 to 18 months to determine whether the prophylaxis is successful [28]. Owing to the possible maternal blood contamination and transplacental leakage of maternal HBsAg and HBeAg to cord blood [32], detection of HBV serologic markers in cord blood or neonatal peripheral blood shortly after birth cannot determine whether the infants are infected [33]. However, only 38.2% of the respondents correctly answered this question in the present investigation.…”

Section: Discussionmentioning

confidence: 99%

A knowledge survey of obstetrics and gynecology staff on the prevention of mother-to-child transmission of hepatitis B virus

Dai

Zhou

et al. 2013

J Infect Dev Ctries

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Introduction: This survey was designed to investigate the knowledge awareness of obstetrics and gynaecology staff (Obs/Gyn staff) on the prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV). Methodology: Obs/Gyn staff from 21 of the 31 Chinese mainland provinces, who attended medical meetings or training classes from July to October 2011, were invited to complete a questionnaire regarding PMTCT of HBV. The questionnaire included the clinical implications of HBV serologic markers and PMTCT preventive measures for both pregnant women and infants. Results: A total of 828 questionnaires were distributed, 617 (74.5%) Obs/Gyn staff participated in the survey, and 559 (90.6%) questionnaires met the inclusion criteria. Overall, 90% of participants correctly determined the positive hepatitis B surface antigen (HBsAg) as infectious, but up to 27.5% mistakenly considered the presence of anti-HBe and/or anti-HBc with negative HBsAg as infectious. In total, 96.3% respondents knew that pregnant women should be screened for HBV infection, and 95.3% realized that infants of HBsAg-positive mothers should be injected with hepatitis B immunoglobulin and vaccine. On the other hand, with the available immunoprophylaxis, 13.8% participants mistakenly believed caesarean section may prevent HBV mother-to-child transmission, and only 13% correctly answered that newborns of HBsAg positive mothers may be breastfed. Conclusion: Obs/Gyn staff in China have mastered the strategies of HBV PMTCT, but there is obvious insufficiency in details of the application. Intensified efforts to train the Obs/Gyn staff are required to improve the current suboptimal medical service in HBV-exposed infants and to control mother-to-infant transmission of HBV.

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“…Mothers of viremic newborns did not have significantly higher perinatal mean HBV-DNA levels when compared with those of non-viremic newborns (2.61 versus 2.17 log 10 copies/mL, p = 0.719). 1 The p-value was not significant. However, according to a review of the literature and guidelines, this result appears odd.…”

mentioning

confidence: 86%

“…Dear Editor, I read with interest the recently published article by Papaevangelou et al 1 in your journal. The study was designed to find risk factors for HBV transmission from HBsAg positive mothers to their infants.…”

mentioning

confidence: 99%

Transmission of HBV infection from mothers HBsAg positive to infants need to more attention

Alavian¹

2012

Journal of Clinical Virology

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HBV viremia in newborns of HBsAg(+) predominantly Caucasian HBeAg(−) mothers

Cited by 13 publications

References 31 publications

Effect of elective cesarean section on the risk of mother-to-child transmission of hepatitis B virus

Effect of elective cesarean section on the risk of mother-to-child transmission of hepatitis B virus

A knowledge survey of obstetrics and gynecology staff on the prevention of mother-to-child transmission of hepatitis B virus

Transmission of HBV infection from mothers HBsAg positive to infants need to more attention

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