HBXIP protein overexpression predicts the poor prognosis of pancreatic ductal adenocarcinomas

Zhou, Xingzhi; Wang, Xuanyu; Duan, Jiahong; Chen, Zhuo; Li, Qiulan; Ou, Zitong; Ge, Jingping; Ren, Xiubao; Liu, Shuangping

doi:10.1016/j.prp.2018.12.016

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Prediction of worse survival in patients with tumors and high expression of HBXIP. In the past decade, studies have reported that HBXIP is highly expressed in breast cancer, esophageal squamous cell carcinoma, colorectal, gastric cancer, renal cancer, liver cancer, tongue squamous cell carcinoma and pancreatic cancer, and its expression associated with the clinicopathological characteristics, prognosis and survival of patients (Table I) (6)(7)(8)(9)(10)(11)(12)(13)(14). Furthermore, HBXIP expression is associated with tumor metastasis, stage and survival of different tumor types (6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Hbxip and Tumorsmentioning

confidence: 99%

“…In the past decade, studies have reported that HBXIP is highly expressed in breast cancer, esophageal squamous cell carcinoma, colorectal, gastric cancer, renal cancer, liver cancer, tongue squamous cell carcinoma and pancreatic cancer, and its expression associated with the clinicopathological characteristics, prognosis and survival of patients (Table I) (6)(7)(8)(9)(10)(11)(12)(13)(14). Furthermore, HBXIP expression is associated with tumor metastasis, stage and survival of different tumor types (6)(7)(8)(9)(10)(11)(12)(13)(14). Therefore, high expression of HBXIP often predicts a higher degree of malignancy, and promotes tumor cell proliferation and invasion through different mechanisms.…”

Section: Hbxip and Tumorsmentioning

confidence: 99%

“…HBXIP is highly expressed in numerous types of cancer, such as breast cancer, gastric cancer and esophageal squamous cell carcinoma, and its expression is associated with certain clinicopathological characteristics (6)(7)(8)(9)(10)(11)(12)(13)(14). Furthermore, high levels of HBXIP expression are associated with a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Cheng,

Guo,

Zou

et al. 2024

Mol Med Rep

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Hepatitis B X-interacting protein (HBXIP) is a membrane protein located on the lysosomal surface and encoded by the Lamtor gene. It is expressed by a wide range of tumor types, including breast cancer, esophageal squamous cell carcinoma and hepatocellular carcinoma, and its expression is associated with certain clinicopathological characteristics. In the past decade, research on the oncogenic mechanisms of HBXIP has increased and the function of HBXIP in normal cells has been gradually elucidated. In the present review, the following was discussed: The normal physiological role of the HBXIP carcinogenic mechanism; the clinical significance of high levels of HBXIP expression in different tumors; HBXIP regulation of transcription, post-transcription and post-translation processes in tumors; the role of HBXIP in improving the antioxidant capacity of tumor cells; the inhibition of ferroptosis of tumor cells and regulating the metabolic reprogramming of tumor cells; and the role of HBXIP in promoting the malignant progression of tumors. In conclusion, the present review summarized the existing knowledge of HBXIP, established its carcinogenic mechanism and discussed future related research on HBXIP.

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Section: Hbxip and Tumorsmentioning

confidence: 99%

Section: Hbxip and Tumorsmentioning

confidence: 99%

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Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Cheng,

Guo,

Zou

et al. 2024

Mol Med Rep

Self Cite

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show abstract

“…It has been shown that HBXIP promotes proliferation, migration and tumorigenesis of breast, ovarian, liver, non-small-cell lung, bladder urothelial, and esophageal squamous cell cancer (Hu et al, 2011, Liu et al, 2012, Liu et al, 2014, Xu et al, 2014, Zhang et al, 2014, Li and Liu, 2016, Shi et al, 2016, Wang et al, 2017b, Zhou et al, 2019b, Wu et al, 2020). Overexpression of HBXIP is associated with poor prognosis in breast, ovarian, liver, non-small-cell lung cancer and pancreatic ductal adenocarcinomas (Wang et al, 2017b, Li et al, 2017, Wang et al, 2017c, Zhou et al, 2019a, Cheng et al, 2014). HBXIP also contributes to cisplatin and tamoxifen resistance in ovarian and breast cancers, respectively (Zou et al, 2017, Liu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Hbxip (Lamtor5) is essential for embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1

Qin

Zhang

et al. 2022

Preprint

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Hbxip, also named Lamtor5, has been well characterized as a transcriptional coactivator in various cancers. However, the role of Hbxip in normal development remains unexplored. Here, we demonstrated that homozygous knockout of Hbxip leads to embryonic lethality, with retarded growth around E7.5. Using Hbxip knockout embryonic stem cells (ESCs), we showed that depletion of Hbxip compromises the self-renewal of ESCs, with reduced expression of pluripotency genes, reduced cell proliferation, and decreased colony forming capacity. In addition, Hbxip-/- ESCs are defective in differentiation, particularly ectodermal and mesodermal differentiation. Consistently, Hbxip-/- epiblast fails to differentiate properly, indicated by sustained expression of Oct4 in E8.5 Hbxip-/- epiblast. Mechanistically, in ESCs, Hbxip interacts with other components of the Ragulator complex, which is required for mTORC1 activation by amino acids. Importantly, ESCs depleted of Ragulator subunits, Lamtor3 or Lamtor4, display differentiation defects similar to those of Hbxip-/- ESCs. Moreover, Hbxip-/-, p14-/-, and p18-/- mice, lacking subunits of the Ragulator complex, also share similar phenotypes, embryonic lethality and retarded growth around E7-8. Thus, we conclude that Hbxip plays a pivotal role in the development and differentiation of the epiblast, as well as the self-renewal and differentiation of ESCs, through activating mTORC1 signaling.

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“…In this study, we used proteomics to identify putative molecular targets of germacrone in gastric cancer. A total of 596 protein candidates were screened, and the top hit was identified as hepatitis B X-interacting protein (HBXIP), a protein that is highly expressed in several types of human cancer ( 21 – 23 ). We found that HBXIP played an important role in the regulation of the cell cycle, apoptosis, and autophagy in gastric cancer cells, and that germacrone exerted its antitumor activity by acting as an antagonist of HBXIP.…”

Section: Introductionmentioning

confidence: 99%