A semi-reduced (70 species, 210 reactions) and a skeletal (27 species, 29 reactions) chemical reaction mechanism for iso-octane are constructed from a semi-detailed isooctane mechanism (84 species, 412 reactions) of the Chalmers University of Technology in Sweden. The construction of the reduced mechanisms is performed by using reduction methods such as the quasi-steady-state assumption and the partial equilibrium assumption. The obtained reduced iso-octane mechanisms show, at the mentioned conditions, a perfect coherence with another more detailed iso-octane mechanism of ENSIC-CNRS (2411 reactions and 473 species) and the semi-detailed iso-octane mechanism of Chalmers. The validity of this mechanism with regard to the ignition delay is determined for several engine parameters adhering to HCCI conditions : inlet temperature (303-363 K), equivalence ratio (0.2-0.7) and compression ratio (10-16). The ignition delay is found to be decreased by an increase in the inlet temperature, H. Machrafi et al. a decrease in the equivalence ratio and an increase in the compression ratio. In order to validate the effects of the inlet temperature, compression ratio on the auto-ignition delay, experiments are performed on a CFR engine. A good agreement is obtained between experimental results and calculations.