HCMV seroprevalence and associated risk factors in pregnant women, Havana City, 2007 to 2008

Correa, Consuelo; Kourí, Vivian; Verdasquera, Denis; Martinez, Pedro A; Álvarez, Alina; Alemán, Yoan; Pérez, Lissette; Viera, Jenniffer; Gonzalez, R.; Pérez, Elevina; Moro, I.; Navarro, María Amparo Gilabert; Melin, Pierrette

doi:10.1002/pd.2587

Cited by 17 publications

(22 citation statements)

References 25 publications

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“…The 65.6% seroprevalence found in pregnant women in Durango is similar to the 62.4%-66% seroprevalences reported in pregnant women in Poland [13], Japan [14], and Norway [15], and higher than the 49% seroprevalence in white British pregnant women in the United Kingdom [16] and a 42.3% seroprevalence in pregnant women in Germany [17]. In contrast, the seroprevalence found in pregnant women in Durango is lower than the 92.6%-100% seroprevalences reported in pregnant women in Iran [18], Palestine [19], Brazil [20], Turkey [21], Nigeria [22], and Cuba [23]. …”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

et al. 2014

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BackgroundCytomegalovirus causes congenital infections all around the world. The seroepidemiology of cytomegalovirus infection in pregnant women in Mexico is largely unknown. We sought to determine the seroprevalence of cytomegalovirus infection in pregnant women in Durango City, Mexico; and to determine seroprevalence association with socio-demographic, clinical and behavioral characteristics of pregnant women.MethodsThrough a cross-sectional study design, 343 pregnant women were examined for anti-cytomegalovirus IgG and IgM antibodies in Durango City, Mexico. We used a standardized questionnaire to obtain the general characteristics of the pregnant women. Multivariate analysis was performed to determine the association of cytomegalovirus infection with the characteristics of the pregnant women.ResultsAnti-CMV IgG and IgM antibodies were detected in 225 (65.6%) and in none of the 343 pregnant women studied, respectively. Multivariate analysis showed that CMV exposure was associated with increasing age (OR = 1.67; 95% CI: 1.01-2.76; P = 0.04). Other women characteristics including socioeconomic status, education, blood transfusion, transplantation, sexual promiscuity and number of previous pregnancies or deliveries did not show an association with CMV exposure.ConclusionsThis is the first seroepidemiology study of CMV infection in pregnant women in Mexico. A number of known factors associated with CMV infection were not associated with CMV exposure in the women studied. Further studies to determine routes of CMV infection in pregnant women in Mexico are needed.

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Section: Discussionmentioning

confidence: 99%

Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

et al. 2014

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“…Alternatively, this could be due to an epidemiological coincidence of infections with diverse viruses. This hypothesis deserves further testing in Cuban population where a high seroprevalence of herpesviruses (CMV, herpes simplex type 1 virus (HSV) and Epstein Barr virus(EBV) infection has been previously described [30-32,56] . …”

Section: Discussionmentioning

confidence: 99%

Immunosenescence and gender: a study in healthy Cubans

et al. 2013

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BackgroundThe progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers.ResultsDifferent populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells.ConclusionShifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly.

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“…There is a lot of debate concerning maternal age and CMV infection; while many investigators observed that, elder women were at higher risk of CMV infection [28], others reported the reverse [31]. However, Bukbuk et al, documented that, increasing maternal age was significantly associated with rubella infection among Nigerian women [32].…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of cytomegalovirus and rubella among pregnant women in western Sudan

Hamdan

Abdelbagi

Nasser

et al. 2011

Virol J

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BackgroundMaternal cytomegalovirus (CMV) and rubella infections have adverse neonatal outcomes. Basic epidemiological data concerning CMV and rubella is necessary for health planners and care providers.MethodsA cross sectional study was conducted at El-Rahad hospital, Sudan to investigate seroprevalence of CMV and rubella infections and associated possible risk factors among pregnant women. Structured questionnaires were used to gather socio-demographic data and ELISA was used to detect CMV and rubella infections using IgG and IgM.ResultsOut of 231 pregnant women, 167 (72.2%) and 151 (65.3%) were CMV-IgG and rubella-IgG positive, respectively. Only 6 (2.5%) and 8 women (3.4%) were CMV-IgM and rubella-IgM positive, respectively. While, high parity (OR = 14.7, 95%CI = 1.7 - 123.6; P = 0.01] and illiteracy (OR = 3.0, CI = 1.4 - 6.5; P = 0.004) were significantly associated with seropostive CMV-IgG in multivariate analysis, none of the other obstetrical and medical characteristics were significantly associated with CMV or rubella infections.ConclusionCMV prevalence was 72.2% and rubella susceptibility among pregnant women was 34.6%. Rubella vaccine and routine screening for rubella and CMV should be introduced for pregnant women in this setting. Further research is needed.

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HCMV seroprevalence and associated risk factors in pregnant women, Havana City, 2007 to 2008

Abstract: Although pregnant women in Cuba have high seroprevalence rates for HCMV, those younger than 20 years and nulligravidae are at risk of acquiring infection during pregnancy.

Cited by 17 publications

References 25 publications

Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

Immunosenescence and gender: a study in healthy Cubans

Seroprevalence of cytomegalovirus and rubella among pregnant women in western Sudan

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