HCV and HBV infection among multitransfused thalassemics from Eastern Sicily

Cacopardo, Bruno; Russo, R; Fatuzzo, Filippo; Cosentino, Stefano; Lombardo, Turiddu; R, La Rosa; Celesia, Benedetto Maurizio; Nigro, Luca Lo; Frontini,; Nunnari, A

doi:10.1007/bf01711069

Cited by 12 publications

(9 citation statements)

References 14 publications

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“…It showed 47% positivity for anti-HCV antibodies. 29 This high incidence is also reported by other studies from some Arabic countries who found an HCV infection rate of 33% in Kuwait 30 and 40% in Bahrain. 31 In our study, Anti-HCV antibody positivity was significantly higher with increased number of blood transfusion.…”

Section: Countrysupporting

confidence: 76%

Prevalence of HBV and HCV infection among multi-transfused Egyptian thalassemic patients

Mansour

Aly

Abdelrazek

et al. 2012

Hematology/Oncology and Stem Cell Therapy

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The prevalence of HCV and HBV infections are very high among Egyptian β-thalassemic patients, which calls for a critical look into the prevailing transfusion practices and adoption of stricter donor selection criteria to decrease the incidence rate of both HCV and HBV infections effectively. Furthermore, there is a compressing need for the use of more specific and sensitive methods for HCV testing in Mansoura university hospitals.

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Section: Countrysupporting

confidence: 76%

Prevalence of HBV and HCV infection among multi-transfused Egyptian thalassemic patients

Mansour

Aly

Abdelrazek

et al. 2012

Hematology/Oncology and Stem Cell Therapy

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“…In the same group of patients we observed a very high prevalence of positivity for anti-HCV antibodies, higher than that previously reported by other Italian authors (Resti et al, 1991;Cacopardo et al, 1992;Rebulla et al, 1992;Lai et al, 1993). This is probably due to the longer exposure to HCV of our adult patients, since seroconversion was strongly correlated with transfusional age before the availability of HCV diagnostic tests (Borzini et al, 1991).…”

Section: Discussionsupporting

confidence: 56%

“…In recent years, following the identification of hepatitis C virus (HCV) and the introduction of diagnostic tests which detected antibodies against HCV , this virus was recognized as the major cause of post-transfusion hepatitis (Alter, 1990;Miyamura et al, 1990). Very high prevalences of HCV markers, usually exceeding 60%, have been described by several authors (Resti et al, 1991;Cacopardo et al, 1992;Rebulla et al, 1992;Lai et al, 1993) in Italian thalassaemia patients.…”

mentioning

confidence: 99%

Prevalence and Clinical Significance of Hepatitis G Virus Infection in Adult Beta‐thalassaemia Major Patients

et al. 1997

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Summary. The risk of polytransfused patients for hepatitis C virus (HCV) infection is likely to extend to another recently identified member of the Flaviviridae, hepatitis G virus (HGV). We investigated the prevalence of HGV in 40 adult Italian patients with transfusion-dependent thalassaemia and evaluated the clinical significance of HGV infection. HGV-RNA was detected in 9/40 patients (22·5%). HGV infection was significantly associated with HCV viraemia (P ¼ 0·0012), with all patients positive for HGV being also viraemic for HCV. Overall, the clinical picture of patients with HCV/HGV co-infection was not different from that of patients with isolated HCV. However, patients co-infected with both viruses had lower values of alanine-transferase (P ¼ 0·035) and a lower titre of HCV viraemia (P ¼ 0·042) in the absence of other evident factors which could influence the clinical expression of HCV infection. In conclusion, HGV is highly prevalent among Italian polytransfused patients. No evidence of a clinically significant pathogenic role for HGV in liver disease could be found in these patients. In a subset of cases a possible interference of HGV with HCV infection was observed.

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“…Our results indicated that thalassemia subjects who were positive for HCV antibody had thalassemia major, longer duration of blood transfusion [odds ratio (OR), 2.90; 95% confidence interval (CI), 0.063–133.647] and received higher number of blood units (OR, 2.160; 95% CI, 0.089–52.291) than those who were HCV‐seronegative. Other studies have also reported correlation between the two latter risk factors and seropositivity for HCV antibody in this population [10,11]. These variables may explain higher exposure rate to HCV in seropositive subjects compared with those who are HCV antibody‐negative.…”

Section: Discussionmentioning

confidence: 54%

Hepatitis C virus genotypes among patients with thalassemia and inherited bleeding disorders in Markazi province, Iran

Samimi-Rad

Shafiei

2007

Haemophilia

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Hepatitis C virus (HCV) genotypes, multiple genotypes infection and HCV seroprevalence were investigated among 98 thalassemia patients and 76 haemophiliacs in Markazi province, Iran. HCV antibody was detected in 5 (5.1%) of the first group and 33 (43.4%) of the latter. Risk factors associated with anti-HCV antibody were also determined. Anti-HCV positivity in thalassemiacs were related to the number of blood transfusion units, splenectomy and duration of thalassemia. Analysis of risk factors in haemophiliacs revealed that seropositivity was significantly associated with duration of transfusion (P =0.009) and severity of disease (P = 0.000). The prevalence of HCV antibody in thalassemia subjects dropped from 8.1% to 0% after implementation of anti-HCV screening (1996). It was found that higher prevalence of HCV antibody in haemophiliacs (43.4%) compared with thalassemia patients (5.1%) correlated with clotting factor concentrates. Of the 34 seropositive haemophilia patients, HCV RNA was detected in 23 (67.7%). HCV genotype distribution was one in 50%, three in 18.2%, two in 4.54% and mixed in 27.3% (1 + 2 in 9.1%, 1 + 3 in 4.54%, 1 + 4 in 9.2% and 2 + 3a in 4.54%) cases. Among the five anti-HCV-positive thalassemiacs, two (40%) were positive for HCV RNA and one sample was found to be subtype 3a. This study confirms that multitransfused patients in Markazi province had similar genotype distribution as those previously reported form some other regions of Iran. Considering the possibilities of HCV mixed genotype among patients with haemophilia and thalassemia, accuracy and precision should be highly concerned in the detection of genotypes and their subsequent treatment.

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HCV and HBV infection among multitransfused thalassemics from Eastern Sicily

Cited by 12 publications

References 14 publications

Prevalence of HBV and HCV infection among multi-transfused Egyptian thalassemic patients

Prevalence of HBV and HCV infection among multi-transfused Egyptian thalassemic patients

Prevalence and Clinical Significance of Hepatitis G Virus Infection in Adult Beta‐thalassaemia Major Patients

Hepatitis C virus genotypes among patients with thalassemia and inherited bleeding disorders in Markazi province, Iran

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