HCV-associated hepatocellular carcinoma -without cirrhosis

El-Refaie, A.; Savage, Kay; Bhattacharya, Soumyak; Khakoo, Salim I.; Harrison, Tim J.; El-Batanony, Mohamed H.; Soliman, E. S.; Nasr, Soha A.; Mokhtar, Nadia; Amer, Kamal; Scheuer, P. J.; Dillon, Audrey

doi:10.1097/00042737-199606000-00026

Cited by 7 publications

(7 citation statements)

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“…The occurrence of cirrhosis before the appear- ance of neoplastic transformation in the majority of patients suggests that this histologic stage, characterized by continuous regeneration and remodeling of the liver, is an important factor in the development of HCC. 31 On the other hand, HCV positive tumors in noncirrhotic livers have been described, 32,33 giving rise to the question of whether the virus has a direct effect on malignant transformation. The biologic properties of HCV proteins are not well understood, and possible cooperation with cellular components are currently under investigation.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus infection associated with human hepatocellular carcinoma

Pontisso

Belluco

Bertorelle

et al. 1998

Cancer

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Section: Discussionmentioning

confidence: 99%

Hepatitis C virus infection associated with human hepatocellular carcinoma

Pontisso

Belluco

Bertorelle

et al. 1998

Cancer

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“…Hepatitis C virus. Viral Hepatitis C (HCV) infection is an important risk factor for HCC (Gerber 1993; ElRefaie et al. 1996).…”

mentioning

confidence: 99%

Experimental mouse models for hepatocellular carcinoma research

Heindryckx

Colle

Vlierberghe

2009

Int J Experimental Path

320

342

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Every year almost 500,000 new patients are diagnosed with hepatocellular carcinoma (HCC), a primary malignancy of the liver that is associated with a poor prognosis. Numerous experimental models have been developed to define the pathogenesis of HCC and to test novel drug candidates. This review analyses several mouse models useful for HCC research and points out their advantages and weaknesses. Chemically induced HCC mice models mimic the injury-fibrosis-malignancy cycle by administration of a genotoxic compound alone or, if necessary, followed by a promoting agent. Xenograft models develop HCC by implanting hepatoma cell lines in mice, either ectopically or orthotopically; these models are suitable for drug screening, although extrapolation should be considered with caution as multiple cell lines must always be used. The hollow fibre assay offers a solution for limiting the number of test animals in xenograft research because of the ability for implanting multiple cell lines in one mouse. There is also a broad range of genetically modified mice engineered to investigate the pathophysiology of HCC. Transgenic mice expressing viral genes, oncogenes and/or growth factors allow the identification of pathways involved in hepatocarcinogenesis

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“…10 The exact etiologic mechanism of hepatocarcinogenesis in patients with HCV-related cirrhosis is currently unknown; however, necrosis and regeneration of hepatocytes by chronic inflammation in the liver might be involved in the development of HCC. 11,12 Alternatively, it is possible that certain viral proteins may interact with oncogenes or tumor suppressor genes that regulate the cell cycle. 13,14 However, the relation between HCV and the development of HCC is currently not clear.…”

mentioning

confidence: 99%