HCV core antigen testing in HIV- and HBV-coinfected patients, and in HCV-infected patients on hemodialysis

Mederacke, Ingmar; Potthoff, Andrej; Meier, Matthias; Raupach, R.; Manns, Michael P.; Wedemeyer, Heiner; Tillmann, Hans L.

doi:10.1016/j.jcv.2011.11.009

Cited by 36 publications

(36 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These two markers of HCV infection may be present in varying permutations in patients, requiring careful analysis for interpretation (22). In this study, the prevalence of HCV is 3.0% by PCR RNA, our concordance rate (77.8%), compares well with the concordance of studies from other parts of the world (23,24) and is consistent with the WHO estimated HCV prevalence of 2.2% -3.0%. 26,27 This HCV prevalence however, is low compared with previous findings reported from Jos by Egesie et al 28 in 2011 and Egah et al (29) in 2004 both studies were done among blood donors.…”

Section: Discussionsupporting

confidence: 91%

Epidemiology of Hepatitis B and Hepatitis C Virus infections among HIV counseling and testing clients in Jos, North central Nigeria

Peter¹,

Olayinka²,

Agbaji³

et al. 2015

Af J Clin Exp Micro

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Epidemiology of Hepatitis B and Hepatitis C Virus infections among HIV counseling and testing clients in Jos, North central Nigeria

Peter¹,

Olayinka²,

Agbaji³

et al. 2015

Af J Clin Exp Micro

View full text Add to dashboard Cite

show abstract

“…It should be noted that the correlation between both assays appeared to be higher among the coinfected group than the monoinfected group (r = 0.939 and r = 0.845, respectively). Indeed, the correlation coefficients between the two markers in coinfected patients exceeded 0.90 in most previous studies [15,16,17]. For example, a recent cross-sectional survey conducted in China demonstrated that the correlation coefficients between HCVcAg and HCV RNA concentrations was higher in coinfected than monoinfected subjects (r = 0.952 and r = 0.808, respectively) [17].…”

Section: Discussionmentioning

confidence: 94%

“…For example, a recent cross-sectional survey conducted in China demonstrated that the correlation coefficients between HCVcAg and HCV RNA concentrations was higher in coinfected than monoinfected subjects (r = 0.952 and r = 0.808, respectively) [17]. Another study conducted in Germany showed that the correlation coefficients between these two markers in HCV/HIV coinfection was 0.97 compared to 0.75 in HCV monoinfection [16]. …”

Section: Discussionmentioning

confidence: 99%

“…As a result, HCVcAg testing is considered to be an alternative assay to conventional HCV RNA quantification with the advantages of rapidity, reproducibility and feasibility in settings with limited resources [14]. To date, data regarding the correlation between HCVcAg and HCV RNA levels in patients coinfected with HIV are still limited [15,16,17]. In addition, the effect of different viral genotypes, particularly HCV-6 prevalent in Southeast Asia [18], on HCVcAg levels and the correlation with HCV RNA levels remains to be established.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Correlation between Hepatitis C Core Antigen and Hepatitis C Virus RNA Levels with Respect to Human Immunodeficiency Virus Status, Hepatitis C Virus Genotype and Interferon-Lambda-4 Polymorphism

Thông¹,

Akkarathamrongsin²,

Avihingsanon³

et al. 2015

Intervirology

View full text Add to dashboard Cite

Objectives: Serum hepatitis C virus (HCV) core antigen (HCVcAg) concentrations correlate with HCV RNA levels in HCV monoinfected patients. Data in HCV/HIV coinfected patients are still limited. We aim to compare the use of HCVcAg measurement with respect to HIV status, HCV genotypes, interferon-lambda-4 (IFNL4) polymorphism and clinical parameters. Methods: We analyzed an untreated cohort of 104 patients with HCV monoinfection and 85 patients with HCV/HIV coinfection. Serum HCVcAg was measured by a commercial chemiluminescent microparticle immunoassay. The presence of IFNL4 polymorphism ss469415590 was identified by real-time PCR. Results: log₁₀ HCVcAg levels were significantly correlated with corresponding log₁₀ HCV RNA levels (r = 0.889, p < 0.001), but not with ALT levels and liver stiffness. The correlation between HCV RNA and HCVcAg was particularly high in coinfected patients and those with high viremia. Mean log₁₀ HCVcAg concentration was significantly higher in coinfected patients than in monoinfected patients. Patients harboring the TT/TT genotype of ss469415590 had significantly higher levels of log₁₀ HCVcAg than those with the non-TT/TT genotype. HCVcAg levels were similar across HCV genotypes. Conclusions: HCVcAg concentrations had an excellent correlation with HCV RNA levels, particularly in HCV/HIV-coinfected individuals and might be associated with IFNL4 polymorphism. HCVcAg testing could be used as an alternative to HCV RNA assays in resource-limited settings.

show abstract

“…The main advantage of HCVcAg is its excellent correlation with HCV RNA accompanied by much lower costs [50][51][52]. In our previous study baseline HCVcAg concentration correlated with HCV RNA level, its on-treatment decline was faster, and it predicted a virologic response [7].…”

Section: Discussionmentioning

confidence: 99%

Effect of HCV Core Antigen and RNA Clearance during Therapy with Direct Acting Antivirals on Hepatic Stiffness Measured with Shear Wave Elastography in Patients with Chronic Viral Hepatitis C

Łucejko

Flisiak

2018

Applied Sciences

View full text Add to dashboard Cite

Abstract:To assess a combination of novel measures of therapeutic success in the treatment of chronic hepatitis C (CHC) infection, we evaluated liver stiffness (LS) with shear wave elastography and hepatitis C virus core antigen (HCVcAg) concentrations. We followed 34 patients during and after treatment with direct acting antivirals. All patients achieved a sustained virologic and serologic response and a significant increase of albumin levels. Decreases of alanine aminotransferase (ALT) activity and alpha-fetoprotein (AFP) level were observed during the treatment and follow-up period. A significant decrease in LS was observed between baseline, end of treatment (EOT), and at 24-and 96-week post-treatment follow-up. LS decline between EOT and 96-week follow-up (FU96) was observed in 79% of patients. Significant LS changes were seen in patients with advanced fibrosis, particularly in cirrhotics and in patients with ALT exceeding 100 IU/mL. There was a positive correlation between ALT activity and LS changes at the baseline versus FU96. A negative correlation was demonstrated between individual HCVcAg baseline concentrations and reduction of LS at the baseline versus FU96. In conclusion, we observed that LS significantly declined during and after antiviral treatment. It was accompanied by improvement in some liver function measures, and disappearance of both HCVcAg and HCV ribonucleic acid (HCV RNA).

show abstract

HCV core antigen testing in HIV- and HBV-coinfected patients, and in HCV-infected patients on hemodialysis

Cited by 36 publications

References 22 publications

Epidemiology of Hepatitis B and Hepatitis C Virus infections among HIV counseling and testing clients in Jos, North central Nigeria

Epidemiology of Hepatitis B and Hepatitis C Virus infections among HIV counseling and testing clients in Jos, North central Nigeria

The Correlation between Hepatitis C Core Antigen and Hepatitis C Virus RNA Levels with Respect to Human Immunodeficiency Virus Status, Hepatitis C Virus Genotype and Interferon-Lambda-4 Polymorphism

Effect of HCV Core Antigen and RNA Clearance during Therapy with Direct Acting Antivirals on Hepatic Stiffness Measured with Shear Wave Elastography in Patients with Chronic Viral Hepatitis C

Contact Info

Product

Resources

About