HCV elimination in Hong Kong – Non-government organisation (NGO) activities

Lai, Jimmy Shiu Ming; Ho, Agnes Hiu-Yan; Wu, Claudia Wing-Kwan; Wong, Grace Lai–Hung

doi:10.35772/ghm.2021.01049

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…The small floor area size of the clinics and lack of medical service infrastructure did not allow onsite HCV RNA testing to be simultaneously performed in the same clinic session. Despite these shortcomings, the identification of methadone clinics as a setting for providing HCV screening and the support of CBO for reaching potential cases ( Lai et al., 2021 ) form the basis for developing scaled-up programs to reach PWID in Hong Kong. Nevertheless, the selection of settings for onsite HCV screening may vary from place to place.…”

Section: Discussionmentioning

confidence: 99%

Point-of-care hepatitis C reflex testing and treatment referral in methadone clinic settings in Hong Kong—a pilot study

Wong

Chan

et al. 2022

IJID Regions

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Section: Discussionmentioning

confidence: 99%

Point-of-care hepatitis C reflex testing and treatment referral in methadone clinic settings in Hong Kong—a pilot study

Wong

Chan

et al. 2022

IJID Regions

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Real‐World Evaluation of Point‐of‐Care Testing for Hepatitis C Antibodies: Navigating Hepatitis C Elimination Effort

Yew,

Sim,

Hawkins

et al. 2024

Journal of Viral Hepatitis

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An HCV elimination program aims to diagnose more than 90% of Chronic HCV cases. We critically evaluated the performance of a point‐of‐care test (POCT) using an HCV Rapid Antibody Test. PWID from 4 Halfway Houses (HWH) in Singapore were recruited from March 2022 to April 2023. Participants were concurrently screened for HCV via venous blood for anti‐HCV serology and using fingerstick capillary whole blood (FSWB) and oral mucosal transudates (OMT) for POCT, which were interpreted by trained personnel. A blinded study team member independently assessed images of POCTs. Of 207 participants, 37.3% were anti‐HCV positive. Compared to anti‐HCV serology, POCT performance on FSWB and OMT were: Sensitivity 81.8 (73.2–90.4), 74.0 (64.2–83.8), p = 0.014; Specificity 100.0 (100.0–100.0), 98.5 (96.3–100), p = 0.157. Sub‐group analysis of strict 30‐min pre‐test nil‐by‐mouth instruction in 103 subjects reported Sensitivity 77.5 (64.6–90.4), 77.5 (64.6–90.4) and Specificity 100.0 (100.0–100.0) and 98.4 (95.3–100.0). OMT positivity and false‐negative outcomes did not correlate with the sample analytical cutoff index signal distribution of anti‐HCV Serology. Inter‐class correlation between real‐time and imaging readings of POCT for FSWB and OMT at 20 and 40 min were Kappa 0.9666, 0.9674; 0.8803, 0.8940. Proper preparation and patient selection enhance test performance. Differences in oral fluid immunoglobulin secretion, oral pathology, age, and sample collection can affect POCT OMT readings. POCT OMT is promising in serial and self‐testing, complementing its convenience in testing.

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HCV elimination in Hong Kong – Non-government organisation (NGO) activities

Cited by 2 publications

References 12 publications

Point-of-care hepatitis C reflex testing and treatment referral in methadone clinic settings in Hong Kong—a pilot study

Point-of-care hepatitis C reflex testing and treatment referral in methadone clinic settings in Hong Kong—a pilot study

Real‐World Evaluation of Point‐of‐Care Testing for Hepatitis C Antibodies: Navigating Hepatitis C Elimination Effort

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