HCV genotypes in Northern Italy: a survey of 1368 histologically proven chronic hepatitis C patients

Roffi, Luigi; Ricci, Alessia Andrea; Ogliari, Cristina; Scalori, Astrid; Minola, E.; Colloredo, Guido; Donada, Carlo; Ceriani, Roberto L.; Rinaldi, G.; Paris, Bruno; Fornaciari, Giovanni; Morales, Rino; Poggio, P. Del; Sangiovanni, A.; Buonocore, Marco; Bellia, Valentina; Riboli, Paolo; Nava, Maria Cristina; Panizzuti, Fabio; Piperno, Alberto; Pozzi, Massimo; Pioltelli, Pietro; Mancia, Giuseppe

doi:10.1016/s0168-8278(98)80249-3

Cited by 75 publications

(62 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, it was detected, alone, or associated with other genotypes in 63.6% of cases. HCV genotype distribution in our cohort of patients is similar to that observed generally in the Italian population 35 and in other studies on hemophiliacs from the same Italian regions, 36,37 but it is quite different from data coming from trials on hemophiliacs in other countries. [38][39][40][41][42][43][44] Furthermore, as hemophiliacs have been exposed to clotting factor concentrates prepared from thousands of donors, some of them have been infected by multiple HCV genotypes.…”

Section: Discussionsupporting

confidence: 78%

The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders

Franchini

Rossetti

Tagliaferri

et al. 2001

Blood

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 78%

The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders

Franchini

Rossetti

Tagliaferri

et al. 2001

Blood

View full text Add to dashboard Cite

“…32 One study determined HCV genotype-3 as an independent predictor of liver fibrosis progression. 17 Since our cases were mostly infected with HCV genotype 1 virus, a healthy evaluation of effect of genotype on liver fibrosis could not be made because genotype 3 infected cases were limited in number.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Ceylan¹,

Yardimci²,

Fincancı³

et al. 2012

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to investigate the independent variables for the degree of liver fibrosis in patients with chronic hepatitis C virus (HCV) infection. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this cross-sectional retrospective study, the patients were divided in two groups as Group A (patients with fibrosis score 0-2) and Group B (patients with fibrosis score 3-4) and they were compared in terms of age, gender, body mass index, alcohol consumption, presence of diabetes, serum HCV RNA, alanine aminotransferase, gamma-glutamyl transferase, and aspartate aminotransferase, total bilirubin, albumin, globulin and alkaline phosphatase levels, prothrombin time, blood thrombocyte count, splenomegaly in ultrasonographic examination, HCV genotype and liver steatosis. R Re es su ul lt ts s: : Of 201 patients, 93 (46.3%) were males; the median age was 51 (range: 18-77) years. It was found that serum gamma-glutamyl transferase and aspartate aminotransferase levels, age, prothrombin time and the presence of splenomegaly were independent variables predictive of advanced liver fibrosis. Odds ratio and p values were 1.984 and 0.013 for gamma-glutamyl transferase, 1.633 and 0.018 for aspartate aminotransferase, 1.861 and 0.003 for age, 5.598 and 0.008 for splenomegaly and 0.541 and 0.007 for prothrombin time, respectively. C Co on nc cl lu us si io on n: : The results of this study suggested that advanced age, elevated serum gamma-glutamyl transferase and, aspartate aminotransferase levels, prolonged prothrombin time and the presence of splenomegaly are independent variables determining severe liver fibrosis. K Ke ey y W Wo or rd ds s: : Liver cirrhosis; hepacivirus Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı kronik hepatit C virüsü (HCV) enfeksiyonlu olgularda karaciğer fibrozunun derecesini belirleyen bağımsız değişkenleri araştırmaktı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu geriye dönük kesitsel çalışmada hastalar Grup A (fibroz skoru 0-2 olanlar) ve Grup B (fibroz skoru 3-4 olanlar) olarak iki gruba ayrıldı ve gruplar yaş, cinsiyet, beden kitle indeksi, alkol kullanımı, diyabet varlığı, serum HCV RNA, alanin aminotransferaz, gama-glutamil transferaz, aspartat aminotransferaz, total bilirubin, albumin, globulin ve alkalen fosfataz seviyeleri, protrombin zamanı, kan trombosit sayısı, ultrasonografide splenomegali varlığı, HCV genotip ve karaciğer yağlanması açısın-dan karşılaştırıldı. B Bu ul lg gu ul la ar r: : İkiyüz bir hastadan 93 (%46,3)'ü erkekti ve ortanca yaş 51 (alt ve üst sınırlar: 18-77 yıl) idi. Serum gama-glutamil transferaz ve aspartat aminotransferaz düzeyleri, yaş, protrombin zamanı ve splenomegalinin ileri karaciğer fibrozunu belirleyen bağımsız değişkenler olduğu bulundu. Odds oranı ve p değerleri gamaglutamil transferaz için 1,984 ve 0,013; aspartat aminotransferaz için 1,633 ve 0,018; yaş için 1,861 ve 0,003; splenomegali için 5,598 ve 0,008 ve protrombin zamanı için 0,541 ve 0,007 idi. S So on nu uç ...

show abstract

“…Viral concentration is an important factor in regard to treatment issues, 30,31 but there is no evidence to indicate that it has any effect on disease progression. 32,33 Similarly, viral genotype has profound treatment implications, 30,31 but most investigators have failed to identify genotype as an indicator of likely progression, 34,35 although there are rare reports that suggest a higher rate of progression among persons infected with genotype 1b. 36 Regarding the role of quasispecies, studies in humans have suggested that quasispecies evolution is associated with progression of acute to chronic hepatitis C, 37 although studies in chimpanzees have not fully supported this finding.…”

Section: Factors That Might Have An Impact On the Rate Of Progressionmentioning

confidence: 99%

Natural history of chronic hepatitis C

2002

View full text Add to dashboard Cite

Much controversy surrounds the issue of the natural history of hepatitis C virus (HCV) infection. Many authorities view the disease as inexorably progressive with a high probability of advancing over time to cirrhosis and occasionally hepatocellular carcinoma (HCC) and, therefore, likely to be responsible for causing death. Others regard chronic hepatitis C as having a variable outcome, the majority of infected persons not dying from the disease, but more likely from the comorbid conditions that so often accompany infection by this agent, or from more common medical conditions. Disagreements probably derive from the manner of conduct of the study and the populations studied. Efforts to determine natural history are handicapped by the primary characteristics of the disease, namely that its onset rarely is recognized and its course is prolonged exceedingly. Thus, different outcomes have come from retrospective rather than from prospective studies, but both have concluded that at least 20% of chronically infected adults develop cirrhosis within 20 years. More recent studies that used a retrospective/prospective approach, focusing largely on young infected individuals, have produced different results. Among these young people, particularly young women, spontaneous resolution of the viral infection is more common than previously thought and cirrhosis has been identified in 5% or fewer of them. The major failing for all groups studied, young and old, is that natural history studies have rarely exceeded the first 2 decades, so that outcome beyond this time is not known, other than through modeling. Several host-related and extraneous factors probably affect the natural history. (HEPATOLOGY 2002;36:S35-S46.)

show abstract

HCV genotypes in Northern Italy: a survey of 1368 histologically proven chronic hepatitis C patients

Cited by 75 publications

References 45 publications

The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders

The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Natural history of chronic hepatitis C

Contact Info

Product

Resources

About