HCV RNA in blood donors with isolated reactivities by third‐generation RIBA

Lemaire, J. M.; Am, Couroucé; Defer, Christine; Bouchardeau, Françoise; Coste, J.; Agulles, O; Cantaloube, Jean-François; Barlet, Valérie; Barin, Françis

doi:10.1046/j.1537-2995.2000.40070867.x

Cited by 17 publications

(10 citation statements)

References 25 publications

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“…Thirteen women had an indeterminate immunoblot and undetectable HCV RNA and were thus considered HCV indeterminate 39. The prevalence of HCV was 2.9% (42/1435) among HIV-1-infected women compared to 0.5% (2/448) among HIV-uninfected pregnant women ( p = 0.001) (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Human immunodeficiency virus–hepatitis C virus co-infection in pregnant women and perinatal transmission to infants in Thailand

Ngo‐Giang‐Huong

Jourdain

Sirirungsi

et al. 2010

International Journal of Infectious Diseases

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Summary Objectives The objectives of this study were to assess the prevalence and factors associated with hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected and -uninfected Thai pregnant women and the rate of HCV transmission to their infants. Patients and methods Study subjects included 1435 HIV-infected pregnant women and their infants, enrolled in a perinatal HIV prevention trial, and a control group of 448 HIV-uninfected pregnant women. Women were screened for HCV antibodies with an enzyme immunoassay. Positive results were confirmed by recombinant immunoblot and HCV RNA quantification. Infants were tested for HCV antibodies at 18 months or for HCV RNA at between 6 weeks and 6 months. Results Of the HIV-infected women, 2.9% were HCV-infected compared to 0.5% of HIV-uninfected women (p = 0.001). Only history of intravenous drug use was associated with HCV infection in HIV-infected women. Ten percent of infants born to co-infected mothers acquired HCV. The risk of transmission was associated with a high maternal HCV RNA (p = 0.012), but not with HIV-1 load or CD4 count. Conclusions Acquisition of HCV through intravenous drug use partially explains the higher rate of HCV infection in HIV-infected Thai women than in HIV-uninfected controls. Perinatal transmission occurred in 10% of infants of HIV–HCV-co-infected mothers and was associated with high maternal HCV RNA.

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Section: Resultsmentioning

confidence: 99%

Human immunodeficiency virus–hepatitis C virus co-infection in pregnant women and perinatal transmission to infants in Thailand

Ngo‐Giang‐Huong

Jourdain

Sirirungsi

et al. 2010

International Journal of Infectious Diseases

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“…RIBA‐3–indeterminate results may occur during early seroconversion, even in the absence of detectable HCV RNA, 27 and might potentially occur during chronic infection with HCV genotypes other than 1 27‐30 . However, since most RIBA‐3–indeterminate volunteer donors are consistently HCV RNA negative and do not change their antibody pattern over time, this suggests that the vast majority of cases represent resolved HCV infections 31‐34 or false‐positive antibody reactivities 35,36 …”

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus (HCV)‐specific T‐cell responses among recombinant immunoblot assay‐3–indeterminate blood donors: a confirmatory evidence of HCV exposure

et al. 2009

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“…This constellation is not uncommon. In 2000, it was, for example, shown in France that in 758 of 2 million blood donors (0.04%) such indeterminate results occurred 10 . These donors are consequently excluded from blood donations.…”

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confidence: 99%

Cellular immune response to hepatitis C virus (HCV) in nonviremic blood donors with indeterminate anti‐HCV reactivity

et al. 2009

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In almost half of donors the indeterminate result in serologic testings could be explained by a previous resolved HCV infection as the pattern of T-cell response was similar to these patients. These findings indicate that HCV-specific antibodies disappear more rapidly after resolved infection than HCV-specific T cells. These results are important for counseling blood donors and patients with indeterminate serologic results.

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HCV RNA in blood donors with isolated reactivities by third‐generation RIBA

Abstract: HCV RNA-positive donors with indeterminate results in RIBA-3 are extremely rare, but they do exist. They were observed only when either anti-core or anti-NS3 was present. With such a RIBA-3 profile, PCR testing remains necessary to reveal an eventual acute or chronic HCV infection.

Cited by 17 publications

References 25 publications

Human immunodeficiency virus–hepatitis C virus co-infection in pregnant women and perinatal transmission to infants in Thailand

Human immunodeficiency virus–hepatitis C virus co-infection in pregnant women and perinatal transmission to infants in Thailand

Hepatitis C virus (HCV)‐specific T‐cell responses among recombinant immunoblot assay‐3–indeterminate blood donors: a confirmatory evidence of HCV exposure

Cellular immune response to hepatitis C virus (HCV) in nonviremic blood donors with indeterminate anti‐HCV reactivity

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