HCV spontaneous clearers showed low senescence profile in people living with HIV under long ART

Abstract

Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) increases immune activation, inflammation, and oxidative stress that could lead to premature senescence. Different HCV infections, either acute or chronic infection, could lead to distinct premature cellular senescence in people living with HIV (PLWHIV). Observational study in 116 PLWHIV under antiretroviral treatment with different HCV status: (i) n = 45 chronically infected with HCV (CHC); (ii) n = 36 individuals who spontaneously clarify HCV (SC); (iii) n = 35 HIV controls. Oxidative stress biomarkers were analyzed at lipid, DNA, protein, and nitrates levels, as well as

Contribution of viral and bacterial infections to senescence and immunosenescence

“…However, the mechanisms underlying this phenomenon are yet to be elucidated ( Dolan et al., 2006 ). Interestingly, it has been shown in individuals living with HIV and co-infected with HCV that the spontaneous clearance of the latter corelates with a slightly lower senescence profile ( Lara-Aguilar et al., 2023 ).…”