HCV treatment in children and young adults with HIV/HCV co-infection in Europe

Turkova, Anna; Giacomet, Vania; Goetghebuer, Tessa; Miloenko, Milana; Nicolini, Laura Ambra; Noguera-Julián, Antoni; Rojo, Pablo; Volokha, Alla; Indolfi, Giuseppe; Giaquinto, Carlo; Thorne, Claire

doi:10.1016/s2055-6640(20)30504-5

Cited by 11 publications

(16 citation statements)

References 34 publications

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“…WHO estimates that 2.3 million of the 37 million people living with HIV globally are coinfected with HCV. 12 Although HCV coinfection among children living with HIV is less prevalent than that among adults 3 previous studies indicate accelerated liver fibrosis progression and worse treatment outcomes with interferon in children and young people with HIV/HCV coinfection compared with those with HCV monoinfection. 3,4 The results of this study, albeit based on a small sample, add to the currently minimal evidence base of treatment outcomes in adolescents with HIV/HCV coinfection in routine care settings.…”

Section: Discussionmentioning

confidence: 99%

“…2 In the pre-DAA era, populations coinfected with HCV and human immunodeficiency virus (HIV) were considered one of the most difficult-to-treat, as HCV treatment success rates in real-world settings were low at around 30% in adults and 50% in children and young people. 3,4 Although there is substantial real-world evidence on DAA use in adults coinfected with HIV/HCV with high cure rates, DAAs have not yet been widely used in coinfected children and adolescents. 5 Adults and children with HIV/HCV coinfection have more progressive liver disease than their mono-HCV infected counterparts, and lower success with pegylated-interferon/ribavirin treatment, and are considered a priority group for DAA treatment.…”

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confidence: 99%

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Hepatitis C Virus Treatment Response to Direct-acting Antivirals Among Adolescents With HIV/HCV Coinfection: Real-world Data From Ukraine

Malik¹,

Malyuta²,

Volokha³

et al. 2022

Pediatric Infectious Disease Journal

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Direct-acting antivirals (DAAs) have been approved for treating chronic hepatitis C virus (HCV) in children and adolescents. Although DAAs have been used in real-world settings for the treatment of HCV monoinfected adolescents, few reports of real-world use of DAAs in children and adolescents who are coinfected with human immunodeficiency virus (HIV) are available. We evaluated the real-world safety and effectiveness of DAAs in HIV/HCV coinfected adolescents from the Ukraine Paediatric HIV Cohort Study including all those for whom treatment outcomes were available by April 2021. Overall, 6 coinfected adolescents had received DAA treatment; 4 with sofosbuvir/ledipasvir (SOF/LDV), 1 with SOF/ LDV+ribavirin, and 1 with SOF/daclatasvir. No patient discontinued treatment due to adverse events and no serious adverse events were reported. All 6 patients achieved sustained virologic response by 12 weeks after the end of therapy. DAA treatment was well tolerated and effective in adolescents with HIV/HCV coinfection in a real-world setting.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Hepatitis C Virus Treatment Response to Direct-acting Antivirals Among Adolescents With HIV/HCV Coinfection: Real-world Data From Ukraine

Malik¹,

Malyuta²,

Volokha³

et al. 2022

Pediatric Infectious Disease Journal

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“…Co-infection of HIV and HCV among PWID in the Russian Federation is estimated to be as high as 90% (28). While children co-infected with HIV and HCV in the Russian Federation had the highest treatment rate (61%) for HCV of 4 other European countries in one report (29), this trend has not been noted in Russian adults. For instance, only 3% of patients with known HCV reported ever receiving HCV treatment in a cohort of PWID in St. Petersburg (11).…”

Section: Discussionmentioning

confidence: 88%

A Geospatial Bibliometric Review of the HIV/AIDS Epidemic in the Russian Federation

Neils

Pfaeffle

Kulatti

et al. 2020

Front. Public Health

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Background: Increasing rates of HIV/AIDS in Eastern Europe and Central Asia contrast global trends, but the scope of HIV/AIDS research originating from Russian Federation and countries of the former Soviet Union has not been quantified.Methods: We searched six major scientific databases in Russian and English languages with medical subject heading terms "HIV" or "AIDS" and "Russia" or "Soviet Union" from 1991 to 2016. Each abstract indexed was reviewed and tagged for 25 HIV/AIDS research themes, location of research focus and first author.Results and Discussion: A total of 2,868 articles were included; 2,156 (75.1%) and 712 (24.8%) described research in the Russian Federation and countries of the former Soviet Union, respectively. There were 15 publications per million population in Russian Federation. Federal districts of the Russian Federation with the highest rates of HIV had the most limited publications. An interactive web-map with time-lapse features and links to primary literature was created using ArcGIS ® technology [http://arcg.is/2FUIJ5v]. Conclusion:We found a lower than expected publication rate in the Russian Federation relative to rising HIV prevalence. The greatest deficits were in the most HIV burdened regions in the Russian Federation. Our findings highlight opportunities for new research strategies and public health efforts among key populations and subnational regions.

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“…Patients were significantly more likely to be treated if they had advanced fibrosis as defined by transient elastography (e.g. five-fold increased odds of treatment for patients with !9.6 versus 7.2 kPa) and if they were aged more than 18 years [43].…”

Section: Discussionmentioning

confidence: 99%

Coinfection with HIV and hepatitis C virus in 229 children and young adults living in Europe

2017

Aids

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HCV treatment in children and young adults with HIV/HCV co-infection in Europe

Cited by 11 publications

References 34 publications

Hepatitis C Virus Treatment Response to Direct-acting Antivirals Among Adolescents With HIV/HCV Coinfection: Real-world Data From Ukraine

Hepatitis C Virus Treatment Response to Direct-acting Antivirals Among Adolescents With HIV/HCV Coinfection: Real-world Data From Ukraine

A Geospatial Bibliometric Review of the HIV/AIDS Epidemic in the Russian Federation

Coinfection with HIV and hepatitis C virus in 229 children and young adults living in Europe

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