HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration

Zhang, Ruimen; Pan, Yu; Feng, Wanyou; Zhao, Yongqiang; Yang, Ya-Chun; Wang, Leyi; Zhang, Yongwang; Cheng, Juanru; Jiang, Qinyang; Zheng, Zi-Hua; Jiang, Meihui; Yang, Sufang; Deng, Yanfei; Shi, Deshun; Wei, Yanfei

doi:10.1021/acs.jafc.2c03384

Cited by 8 publications

(3 citation statements)

References 34 publications

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“…The Notch signaling pathway plays a crucial role in determining cell fate by influencing cell differentiation, proliferation, and apoptosis ( 67 ). It guides stem cells toward differentiation into specific cell types at different developmental stages and in various tissues, promoting tissue development ( 68 ). It also impacts T-cell development and differentiation, making it vital for the regulation of adaptive immune responses ( 67 , 69 ).…”

Section: Discussionmentioning

confidence: 99%

Ruminal microbiota-host crosstalks promote ruminal epithelial development in neonatal lambs with alfalfa hay introduction

Bian,

Yu,

Cheng

et al. 2024

mSystems

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Ruminal microbiota is gradually established after birth, while microbiota maturation could be highly diverse because of varied solid dietary accessibility. However, how the ruminal microbiota accreted from postnatal hay diets alters rumen epithelial development, and how this affects animal health remains largely unknown. Here, neonatal lambs were introduced to starchy corn-soybean starter or corn-soybean starter + alfalfa hay (AH) to investigate the influences of early life ruminal microbiome on rumen epithelial development using integrated 16s rRNA sequencing-metagenome-transcriptome approaches. The results showed that AH introduction elevated average daily weight gain, rumen weight and volume, rumen epithelial papillae length, and rumen muscle layer thickness. Meanwhile, the relative abundance of fibrolytic bacteria ( Christensenellaceae R-7 group, Prevotellaceae UCG-001, and Succinivibrio ), acetate producer ( Acetitomaculum and Mitsuokella), and propionate producer Succiniclasticum was increased in the rumen content by AH supplementation ( P < 0.05). Moreover, AH introduction decreased the relative abundance of total CAZymes, CBM, and GH and increased the abundance of KO genes related to volatile fatty acid (VFA) generation in the rumen content. AH lambs had a higher relative abundance of Succiniclasticum , Megasphaera, Succinivibrio , and Suttonella ( P < 0.05), while a lower relative abundance of Cloacibacillus , Desulfovibrio , Dialister , Intestinimonas , Parabacteroides , and Pseudoscardovia ( P < 0.05) in the rumen epithelial samples. Furthermore, these alterations in ruminal microbial structure and function resulted in ruminal epithelial cell proliferation and development pathways activation. In summary, AH introduction benefited ruminal fiber degradation and VFA generation bacteria colonization and promoted ruminal epithelial development. These findings provide new insights into ruminal microbial–host interactions in the early life. IMPORTANCE While it is established that a fiber-rich diet promotes rumen development in lambs, further research is needed to investigate the precise response of rumen microbiota and epithelium to high-quality alfalfa hay. Here, we observed that the inclusion of alfalfa hay led to a discernible alteration in the developmental trajectory of the rumen. Notably, there was a favorable shift in the rumen's volume, morphology, and the development of rumen papillae. Furthermore, ruminal microbial structure and function resulted in ruminal epithelial cell proliferation and development pathways activation, collectively provide compelling evidence supporting the capacity of alfalfa hay to enhance rumen development and health through ruminal micrbiota-host crosstalks. Our findings elucidate the functional response of the rumen to alfalfa hay introduction, providing new insights into strategies for promoting healthy development of the rumen in young ruminants.

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Section: Discussionmentioning

confidence: 99%

Ruminal microbiota-host crosstalks promote ruminal epithelial development in neonatal lambs with alfalfa hay introduction

Bian,

Yu,

Cheng

et al. 2024

mSystems

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“…Class IV HDACs include only HDAC11, which presents similarities to both Class I and Class II. It has been found that HDAC11 promotes MuSC proliferation, by activating Notch signaling, and negatively affects skeletal muscle regeneration by reducing MyoD1 transcription [90][91][92]. HDAC11 deletion also increases the number of oxidative myofibers in skeletal muscle by promoting a glycolytic-to-oxidative muscle fibers switch [93].…”

Section: Overview Of the Histone Deacetylases And Their Role In Stria...mentioning

confidence: 99%

Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies

Sandonà

Cavioli

Renzini

et al. 2023

IJMS

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Histone deacetylases (HDACs) are enzymes that regulate the deacetylation of numerous histone and non-histone proteins, thereby affecting a wide range of cellular processes. Deregulation of HDAC expression or activity is often associated with several pathologies, suggesting potential for targeting these enzymes for therapeutic purposes. For example, HDAC expression and activity are higher in dystrophic skeletal muscles. General pharmacological blockade of HDACs, by means of pan-HDAC inhibitors (HDACi), ameliorates both muscle histological abnormalities and function in preclinical studies. A phase II clinical trial of the pan-HDACi givinostat revealed partial histological improvement and functional recovery of Duchenne Muscular Dystrophy (DMD) muscles; results of an ongoing phase III clinical trial that is assessing the long-term safety and efficacy of givinostat in DMD patients are pending. Here we review the current knowledge about the HDAC functions in distinct cell types in skeletal muscle, identified by genetic and -omic approaches. We describe the signaling events that are affected by HDACs and contribute to muscular dystrophy pathogenesis by altering muscle regeneration and/or repair processes. Reviewing recent insights into HDAC cellular functions in dystrophic muscles provides new perspectives for the development of more effective therapeutic approaches based on drugs that target these critical enzymes.

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“…Similar to HDAC4 and HDAC5, HDAC11 downregulates the transcription of MyoD, thereby impeding myoblast differentiation ( Byun et al, 2017 ). HDAC11 also promotes bovine skeletal muscle satellite cell proliferation through the activation of the Notch signaling pathway ( Zhang R. et al, 2022 ). Interestingly, contrary to SIRT6, inhibiting HDAC11 activity upregulates the expression of IL-10, a factor that enhances myogenic differentiation, facilitating the differentiation of skeletal muscle satellite cells and accelerating muscle regeneration ( Nunez-Alvarez et al, 2021 ).…”

Section: Histone Acetylation and Skeletal Muscle Metabolismmentioning

confidence: 99%

The epigenetic regulatory effect of histone acetylation and deacetylation on skeletal muscle metabolism-a review

Xu,

Li,

Kang

2023

Front. Physiol.

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Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis. Epigenetic modification, specifically histone acetylation, serves as a crucial regulatory mechanism influencing the physiological processes and metabolic patterns within skeletal muscle metabolism. The intricate process of histone acetylation modification involves coordinated control of histone acetyltransferase and deacetylase levels, dynamically modulating histone acetylation levels, and precisely regulating the expression of genes associated with skeletal muscle metabolism. Consequently, this comprehensive review aims to elucidate the epigenetic regulatory impact of histone acetylation modification on skeletal muscle metabolism, providing invaluable insights into the intricate molecular mechanisms governing epigenetic modifications in skeletal muscle metabolism.

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HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration

Cited by 8 publications

References 34 publications

Ruminal microbiota-host crosstalks promote ruminal epithelial development in neonatal lambs with alfalfa hay introduction

Ruminal microbiota-host crosstalks promote ruminal epithelial development in neonatal lambs with alfalfa hay introduction

Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies

The epigenetic regulatory effect of histone acetylation and deacetylation on skeletal muscle metabolism-a review

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