HDL associates with insulin resistance and beta-cell dysfunction in South Asian families at risk of type 2 diabetes

Yahya, R.; Jainandunsing, Sjaam; Rashid, Mardin; Zee, Leonie van der; Touw, A.; Rooij, Felix W.M. de; Sijbrands, Eric; Verhoeven, Adrie J.M.; Mulder, Monique

doi:10.1016/j.jdiacomp.2021.107993

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…36,37 Only a single study showed HDL-2 and HDL-3 were associated with insulin resistance and beta cell function in SA at risk of T2DM. 38 In our study, we included both DSA and DwC populations and generated HDL main fractions and subfractions, including 32 features, providing a higher resolution of HDL lipoprotein fraction than HDL-C alone. sPLS-DA based on HDL composition could not only distinguish healthy controls from T2DM in both ethnic groups but also show the distinction between T2DM in these two ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies investigating HDL particle subspecies did not account for the HDL composition, particularly the lipid content, and the majority of these studies were conducted on white ethnic groups 36,37 . Only a single study showed HDL‐2 and HDL‐3 were associated with insulin resistance and beta cell function in SA at risk of T2DM 38 . In our study, we included both DSA and DwC populations and generated HDL main fractions and subfractions, including 32 features, providing a higher resolution of HDL lipoprotein fraction than HDL‐C alone.…”

Section: Discussionmentioning

confidence: 99%

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Altered high‐density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross‐sectional, case‐control study on lipoprotein subclass profiling

Yuan

Li‐Gao

Verhoeven

et al. 2023

Diabetes Obesity Metabolism

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Background Composition of high‐density lipoproteins (HDL) is emerging as an important determinant in the development of microvascular complications in type 2 diabetes mellitus (T2DM). Dutch South Asian (DSA) individuals with T2DM display an increased risk of microvascular complications compared with Dutch white Caucasian (DwC) individuals with T2DM. In this study, we aimed to investigate whether changes in HDL composition associate with increased microvascular risk in this ethnic group and lead to new lipoprotein biomarkers. Materials and Methods Using 1H nuclear magnetic resonance spectroscopy and Bruker IVDr Lipoprotein Subclass Analysis (B.I.LISA) software, plasma lipoprotein changes were determined in 51 healthy individuals (30 DwC, 21 DSA) and 92 individuals with T2DM (45 DwC, 47 DSA) in a cross‐sectional, case‐control study. Differential HDL subfractions were investigated using multinomial logistic regression analyses, adjusting for possible confounders including BMI and diabetes duration. Results We identified HDL compositional differences between healthy and diabetic individuals in both ethnic groups. Specifically, levels of apolipoprotein A2 and HDL‐4 subfractions were lower in DSA compared with DwC with T2DM. Apolipoprotein A2 and HDL‐4 subfractions also negatively correlated with waist circumference, waist‐to‐hip ratio, haemoglobin A1c, glucose levels and disease duration in DSA with T2DM, and associated with increased incidence of microvascular complications. Conclusion While HDL composition differed between controls and T2DM in both ethnic groups, the lower levels of lipid content in the smallest HDL subclass (HDL‐4) in DSA with T2DM appeared to be more clinically relevant, with higher odds of having diabetes‐related pan‐microvascular complications such as retinopathy and neuropathy. These typical differences in HDL could be used as ethnicity‐specific T2DM biomarkers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Altered high‐density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross‐sectional, case‐control study on lipoprotein subclass profiling

Yuan

Li‐Gao

Verhoeven

et al. 2023

Diabetes Obesity Metabolism

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“…The lipid profiles of children with and without VDD differed significantly in terms of HDL ( p < 0.05) and TG ( p < 0.02) levels. Low values of HDL cholesterol are associated with the development of cardiovascular diseases [ 21 , 22 ], as well as type 2 diabetes mellitus [ 23 ], which underlines the importance of HDL as a MetS component. Interestingly, research on African patients showed that low HDL is the most frequent MetS component in this population [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency in Obese Children Is Associated with Some Metabolic Syndrome Components, but Not with Metabolic Syndrome Itself

et al. 2023

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Vitamin D deficiency in children is a common nutritional issue in many populations worldwide, associated not only with skeletal malformations but, as recent studies suggest, also with the development of obesity and metabolic syndrome. The aim of this observational study was to assess the nutritional status of vitamin D in a group of Polish children with obesity and different grades of metabolic syndrome, with a consequent analysis of the correlation between vitamin D levels and the components of metabolic syndrome. For that purpose, the group of 78 participants (mean age: 14.18 ± 2.67 years) was recruited and further grouped in relation to vitamin D status into two groups of children with and without vitamin D deficiency. The biochemical parameters associated with obesity as well as anthropometric measures were assessed and analysed in search of significant differences between the groups. In the current group of children with obesity and vitamin D deficiency, HDL (45.00 ± 9.29) and adiponectin (7.21 ± 1.64) were found to be significantly lower than in their peers without vitamin D deficiency, whereas W/HtR (0.60 ± 0.04) and TG (171.31 ± 80.75) levels proved to be significantly higher. Body composition analysis using bioelectrical impedance returned no significant findings. The above findings suggest that vitamin D deficiency may influence lipid and glucose metabolism in children, leading to the development of abnormalities characteristic of the metabolic syndrome. A W/HtR parameter was shown to be a sensitive marker of abdominal obesity, which might provide an important means of assessing the correlation between vitamin D and this type of obesity. Independently, vitamin D deficiency may also influence the endocrinological function of adipose tissue, leading to lower concentrations of adiponectin. These in turn presented a linear correlation with the high results of the OGTT in the second hour of the test, hinting at its potential role in the pathophysiology of insulin resistance.

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“…In addition, both in vivo and in vitro experiments suggested that continuous exposure of β cells to TG could attenuate the ability of β cells to respond to glucose, and eventually lead to the dysfunction of β cells [55]. In addition, low HDL-C level may predispose to T2DM by damaging the function of β cells and insulin resistance, because a few reports have shown the decrease of HDL-C level is closely linked to the dysfunction of β cells and insulin resistance [56]. At present, the exact mechanism of vitamin D affecting diabetes by restoring serum lipid level has not been clarified, and more research is needed.…”

Section: Discussionmentioning

confidence: 99%

The Relationship of 25(OH)D3 with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province

Zhang

Xue

et al. 2022

Medicina

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Background and Objectives: Studies suggest that vitamin D is involved in the development of type 2 diabetes mellitus (T2DM) and influences serum lipids levels, while lipid disorders are also closely related to T2DM. This study attempts to explore the complex relationship of serum 25(OH)D3, serum lipids, and T2DM among Chinese population. Materials and Methods: A cross-sectional study was carried out among 2326 subjects. The chi-square (χ2) test was applied to compare the prevalence of T2DM or dyslipidemia between two serum 25(OH)D3 levels. Linear regression was applied to analyze the correlation between serum lipids and 25(OH)D3 contents. Univariate and logistic analysis were used to explore the relationship between two lipid levels and T2DM. Mediation analysis was used to explore whether serum lipids mediate the relationship between two serum 25(OH)D3 levels and T2DM. Results: Compared to subjects with 25(OH)D3 ≥ 30 ng/mL, subjects with 25(OH)D3 < 30 ng/mL were higher in the prevalence of T2DM. The occurrences of high TG and low HDL-C were significantly higher in vitamin D deficiency and insufficiency than those in vitamin D sufficiency. Serum 25(OH)D3 content showed a reverse correlation with TC, TG, and LDL-C, but positive correlation with HDL-C. The odds ratios (ORs) (95% confidence intervals, 95%CI) of T2DM by comparing TG ≥ 2.26 mmol/L vs. TG < 2.26 mmol/L and HDL-C < 1.04 mmol/L vs. HDL-C ≥ 1.04 mmol/L in all participants were 2.48 (1.94–3.18) and 1.37 (1.07–1.75), respectively. Serum TG or HDL-C level partially mediated the relationship between two 25(OH)D3 level and T2DM. Conclusions: Serum 25(OH)D3 < 30 ng/mL seems to be associated with T2DM or dyslipidemia (high TG and low HDL-C) in our study, but there is still no proof of a cause–effect relationship. Moreover, serum TG or HDL-C level partially mediated the relationship between 25(OH)D3 levels and T2DM.

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HDL associates with insulin resistance and beta-cell dysfunction in South Asian families at risk of type 2 diabetes

Cited by 5 publications

References 35 publications

Altered high‐density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross‐sectional, case‐control study on lipoprotein subclass profiling

Altered high‐density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross‐sectional, case‐control study on lipoprotein subclass profiling

Vitamin D Deficiency in Obese Children Is Associated with Some Metabolic Syndrome Components, but Not with Metabolic Syndrome Itself

The Relationship of 25(OH)D3 with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province

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