HDL-C, triglycerides and carotid IMT: A meta-analysis of 21,000 patients with automated edge detection IMT measurement

Touboul, Pierre‐Jean; Labreuche, Julien; Bruckert, Éric; Schargrodsky, Hermán; Prati, Patrizio; Tosetto, Alberto; Hernández-Hernández, Rafael; Woo, Kam-Sang; Silva, Honorio; Vicaut, Éric; Amarenco, Pierre

doi:10.1016/j.atherosclerosis.2013.10.011

Cited by 46 publications

(38 citation statements)

References 30 publications

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“…On the other hand, glycemic control might be beneficial for the cholesterol levels and lower HDL cholesterol levels were associated with greater wall thickness rather than greater arterial stiffness. These findings were also suggested by previous reports 19,20,[29][30][31][32][33] . As accumulating evidence shows, LDL is a primary pro-atherogenic lipoprotein and its excess in blood leads to atheroma formation in the arterial wall 34) .…”

Section: Discussionsupporting

confidence: 80%

Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

Takahara

Katakami

Osonoi

et al. 2015

JAT

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Aim:We statistically investigated whether the impact of cardiovascular risk factors on arterial stiffness would be different from that on arterial wall thickness. Methods: We analyzed 1648 Japanese type 2 diabetic patients. Arterial stiffness was evaluated by pulse wave verbosity (PWV) and wall thickness was assessed with carotid intima-media thickness (IMT) by ultrasonography. We developed a common regression model to PWV and IMT by extending the linear mixed model and statistically detected the difference in the impact of cardiovascular risk factors between the two indices. Results: There was a significant correlation between PWV and IMT (r 0.365, p 0.001). Sex, diabetic duration, hemoglobin A1c levels, and the presence of retinopathy and cardiovascular disease were comparable independent risk factors for elevated PWV and IMT. On the other hand, the impact of age, systolic blood pressure, and low-and high-density lipoprotein cholesterol levels were significantly different between the two measurements (all p 0.05). Cholesterol levels were significantly associated with IMT but not with PWV. Age and systolic blood pressure had a significant impact on both measurements, but the impact on PWV was significantly greater than that on IMT. Indeed, patients with low IMT but with advanced age and high systolic pressure had high PWV, whereas patients with low PWV but with impaired cholesterol levels had high IMT. Conclusion:The extended linear mixed model statistically confirmed that the impact of cardiovascular risk factors on elevated PWV and IMT were not identical in Japanese patients with type 2 diabetes mellitus. J Atheroscler Thromb, 2015; 22: 971-980.

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Section: Discussionsupporting

confidence: 80%

Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

Takahara

Katakami

Osonoi

et al. 2015

JAT

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“…An inverse association between total HDL-C and the risk of CVD has been shown in multiple epidemiological studies 23–25 . However, total HDL-C concentration measurement does not offer insight into the variable composition of different HDL-C subfractions responsible for complex functions and atheroprotective mechanisms associated with cardiometabolic outcomes 26 .…”

Section: Discussionmentioning

confidence: 87%

High-density lipoprotein subfractions and carotid plaque: The Northern Manhattan Study

et al. 2014

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Objective The objective of this cross-sectional analysis was to investigate the relation between two major high-density lipoprotein cholesterol (HDL-C) subfractions (HDL2-C and HDL3-C) and carotid plaque in a population based cohort. Methods We evaluated 988 stroke-free participants (mean age 66±8 years; 40% men; 66% Hispanic and 34% Non-Hispanic) with available data on HDL subfractions using precipitation method and carotid plaque area and thickness assessed by a high-resolution 2D ultrasound. The associations between HDL-C subfractions and plaque measurements were analyzed by quantile regression. Results Plaque was present in 56% of the study population. Among those with plaque, the mean±SD plaque area was 19.40±20.46 mm2 and thickness 2.30±4.45 mm. The mean±SD total HDL-C was 46±14 mg/dl, HDL2-C 14±8 mg/dl, and HDL3-C 32±8 mg/dl. After adjusting for demographics and vascular risk factors, there was an inverse association between HDL3-C and plaque area (per mg/dl: beta= −0.26 at the 75th percentile, p=0.001 and beta= −0.32 at the 90th percentile, p=0.02). A positive association was observed between HDL2-C and plaque thickness (per mg/dl; beta= 0.02 at the 90% percentile, p=0.003). HDL-C was associated with plaque area (per mg/dl: beta= −0.18 at the 90th percentile, p=0.01), but only among Hispanics. Conclusion In our cohort we observed an inverse association between HDL3-C and plaque area and a positive association between HDL2-C and plaque thickness. HDL-C subfractions may have different contributions to the risk of vascular disease. More studies are needed to fully elucidate HDL-C anti-atherosclerotic functions in order to improve HDL-based treatments in prevention of vascular disease and stroke.

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“…However, the association of triglycerides was not evident among women, and the negative association of high-density lipoprotein cholesterol was not evident among those aged <60 years. 36 The few previous studies that have investigated the association between PCOS and carotid-IMT may provide insight. However, most, if not all, of the studies were small.…”

Section: Discussionmentioning

confidence: 99%

Prospective Association of Polycystic Ovary Syndrome With Coronary Artery Calcification and Carotid-Intima-Media Thickness

Calderon‐Margalit

Siscovick

Merkin

et al. 2014

ATVB

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Objective— To study the independent associations of polycystic ovary syndrome (PCOS), and its 2 components, hyperandrogenism and anovulation, with coronary artery calcification (CAC) and carotid artery intima-media thickness (IMT). Approach and Results— At the year 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort of young adults, women (mean age, 45 years) with information on menses and hirsutism in their twenties were assessed for CAC (n=982) and IMT (n=988). We defined PCOS as women who had both irregular menses and hyperandrogenism (n=55); isolated oligomenorrhea (n=103) as women who only had irregular menses; and isolated hyperandrogenism (n=156) as women who had either hirsutism or increased testosterone levels. Logistic regressions and general linear models were used to estimate the associations between components of PCOS and subclinical CVD. The prevalence of CAC was 10.3% overall. Women with PCOS had a multivariable adjusted odds ratio of 2.70 (95% confidence interval, 1.31–5.60) for CAC. Women with either isolated oligomenorrhea or isolated hyperandrogenism had no increased risk of CAC when compared with unexposed women. Women with PCOS had significantly increased bulb and internal carotid-IMT measurements; however, no significant differences were noted in bulb or internal carotid artery IMT among women with either isolated oligomenorrhea or isolated hyperandrogenism when compared with unexposed women. There were no differences in common carotid-IMT among the 4 study groups. Conclusions— In this study, women with PCOS, manifested as both anovulation and hyperandrogenism, but not women with one of these manifestations alone, were at increased risk for the development of subclinical CVD.

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HDL-C, triglycerides and carotid IMT: A meta-analysis of 21,000 patients with automated edge detection IMT measurement

Cited by 46 publications

References 30 publications

Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

High-density lipoprotein subfractions and carotid plaque: The Northern Manhattan Study

Prospective Association of Polycystic Ovary Syndrome With Coronary Artery Calcification and Carotid-Intima-Media Thickness

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