HDL cholesterol and clinical outcomes in diabetes mellitus

Ishibashi, Takaharu; Kaneko, Hidehiro; Matsuoka, Satoshi; Suzuki, Yuta; Ueno, Kensuke; Ohno, Ryusei; Okada, Akira; Fujiu, Katsuhito; Michihata, Nobuaki; Jo, Taisuke; Takeda, Norifumi; Morita, Hiroyuki; Node, Koichi; Yasunaga, Hideo; Komuro, Issei

doi:10.1093/eurjpc/zwad029

Cited by 18 publications

(11 citation statements)

References 14 publications

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“…Low levels of HDL are not only indicative of poor metabolic status but also a component of metabolic syndrome (3). In previous studies, HDL levels were low in diabetics (27,28). In our study, we observed that HDL levels were significantly lower in the diabetes group with poor glycemic control than in both the diabetes group with good glycemic control and the control group.…”

Section: Discussionsupporting

confidence: 61%

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Özkan Öztürk,

Ecin

2024

Genel Tıp Dergisi

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Background: Type 2 diabetes mellitus (T2DM) is a major health problem worldwide. As glycemic control worsens, the risk of both microvascular and macrovascular complications increases. . The aim of this study was to investigate the relationship between blood glucose regulation and two different parameters: uric acid/HDL ratio (UHR) and monocyte/HDL ratio (MHR) in male subjects with type 2 diabetes. Methods: In this retrospective study, a total of 166 male patients diagnosed with type 2 diabetes and 83 healthy adult men as a control cohort were included. Diabetic male participants were equally divided into two subgroups: the group with uncontrolled blood glucose (HbA1c levels exceeding 7, n=83) and the group with good glycemic control (HbA1c levels at or below 7, n=83). Our analysis included assessment of several serum markers, including triglyceride, high-density lipoprotein (HDL), uric acid, low-density lipoprotein (LDL), neutrophil, lymphocyte, monocyte, white blood cell, hemoglobin and platelet levels. In addition, uric acid/HDL ratio, body mass index and monocyte/HDL ratio were compared. Results: Creatinine levels were normal in all study participants and ages were similar in the groups. Triglyceride levels were significantly higher in diabetic patients compared to the healthy group (P

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Section: Discussionsupporting

confidence: 61%

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Özkan Öztürk,

Ecin

2024

Genel Tıp Dergisi

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“… 22 , 23 On the contrary, HDL-C in blood lipids plays a protective role. 24 A cross-sectional study involving more than 8000 diabetic patients also proved the view that HDL-C was negatively correlated with insulin resistance steady-state model (HOMA-IR). 25 The reason is that HDL-C mainly plays the role of reversing cholesterol, transporting cholesterol from peripheral tissues, including blood vessel walls, to the liver for metabolism, promoting cholesterol clearance, and maintaining lipid balance in the body.…”

Section: Discussionmentioning

confidence: 91%

Correlation Between Glycolipid Metabolism Levels and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus

Wang,

Pan,

Zhang

et al. 2024

DMSO

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Purpose We investigate the correlation between glucose and lipid metabolism and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) and its diagnostic and predictive value. Patients and Methods A retrospective analysis involved 620 patients diagnosed with T2DM, categorized into two groups based on fundus examination results: the non-diabetic retinopathy group (NDR, n=340) and the diabetic retinopathy group (DR, n=280). We collected baseline patient data, calculated the ratio of glycated hemoglobin (HbA1c) to high-density lipoprotein cholesterol (HDL-C), and analyzed its association with Type 2 Diabetic Retinopathy. Results HbA1c/HDL-C in DR group exhibited significantly higher than the NDR group (P<0.001). Mantel-Haenszel’s chi-square trend analysis indicated a notable linear trend (P<0.001) between HbA1c/HDL-C and DR. HbA1c/HDL-C revealed moderate positive correlations with DR, r=0.342, P<0.001. Binary logistic regression analysis showed systolic blood pressure (SBP), diabetes course, fasting blood glucose (FBG) and HbA1c/HDL-C as independent risk factors for DR in T2DM patients. Restrictive cubic spline analysis demonstrated a significant nonlinear relationship between HbA1c/HDL-C and DR (P total trend <0.001, P nonlinear = 0.0196). ROC curve analysis identified that HbA1c/HDL-C had the highest diagnostic accuracy for DR, with an area under the ROC curve (AUC) of 0.711, 53.2% sensitivity, and 78.2% specificity. Conclusion Our study shows that HbA1c/HDL-C is an independent risk factor for DR in patients with type 2 diabetes. HbA1c/HDL-C has good diagnostic value for DR and can be used as a biological index for early screening of DR.

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“…Numerous studies have identified a tight association between high levels of Non-HDL-C and low levels of HDL-C with the increased likelihood of developing T2DM [ 28 , 29 ]. In a sweeping analysis involving more than three million individuals, a U-shaped relationship between HDL-C levels and clinical outcomes in T2DM patients was observed [ 30 ]. It is particularly noted that an increment in HDL-C levels below 60 mg/dl is associated with a decreased risk of T2DM and its complications [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a sweeping analysis involving more than three million individuals, a U-shaped relationship between HDL-C levels and clinical outcomes in T2DM patients was observed [ 30 ]. It is particularly noted that an increment in HDL-C levels below 60 mg/dl is associated with a decreased risk of T2DM and its complications [ 30 ]. Furthermore, IR, which is associated with abnormal lipid values, emerges as a critical factor influencing the likelihood of T2DM development [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with type 2 diabetes mellitus: recent findings from NHANES 2007–2018

Tan,

Weng,

Yang

et al. 2024

Lipids Health Dis

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Objective This study aims to assess the relationship between NHHR (non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio) and Type 2 diabetes mellitus (T2DM) in US adults, using National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018. Methods This study explored the connection between NHHR and T2DM by analyzing a sample reflecting the adult population of the United States (n = 10,420; NHANES 2007–2018). NHHR was characterized as the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol. T2DM was defined based on clinical guidelines. This research used multivariable logistic models to examine the connection between NHHR and T2DM. Additionally, it included subgroup and interaction analyses to assess variations among different groups. Generalized additive models, smooth curve fitting, and threshold effect analysis were also employed to analyze the data further. Results The study included 10,420 subjects, with 2160 diagnosed with T2DM and 8260 without. The weighted multivariate logistic regression model indicated an 8% higher probability of T2DM for each unit increase in NHHR (OR: 1.08, 95% CI: 1.01–1.15) after accounting for all covariates. Subgroup analysis outcomes were uniform across various categories, demonstrating a significant positive relationship between NHHR and T2DM. Interaction tests showed that the positive link between NHHR and T2DM remained consistent regardless of age, body mass index, smoking status, moderate recreational activities, hypertension, or stroke history, with all interaction P-values exceeding 0.05. However, participants’ sex appeared to affect the magnitude of the connection between NHHR and T2DM (interaction P-value < 0.05). Also, a nonlinear association between NHHR and T2DM was discovered, featuring an inflection point at 1.50. Conclusions Our study suggests that an increase in NHHR may be correlated with a heightened likelihood of developing T2DM. Consequently, NHHR could potentially serve as a marker for estimating the probability of T2DM development.

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HDL cholesterol and clinical outcomes in diabetes mellitus

Abstract: Lay Summary The aim of this study is to clarify whether fasting plasma glucose modifies the U-shaped association between high-density lipoprotein cholesterol and clinical outcomes

Cited by 18 publications

References 14 publications

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Correlation Between Glycolipid Metabolism Levels and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with type 2 diabetes mellitus: recent findings from NHANES 2007–2018

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