HDL-cholesterol as a marker of coronary heart disease risk: the Québec cardiovascular study

Després, Jean‐Pierre; Lemieux, Isabelle; Dagenais, G. R.; Cantin, Bernard; Lamarche, Benoı̂t

doi:10.1016/s0021-9150(00)00603-1

Cited by 290 publications

(161 citation statements)

References 62 publications

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“…It is well known that low levels of HDL are associated with an increased risk of developing cardiovascular diseases [86]; however, high levels of HDL may not always be protective, since in a context of chronic inflammation, HDL particles may be less functional [87].…”

Section: Lipid Abnormalitiesmentioning

confidence: 99%

Abdominal obesity and cardiometabolic risk in children and adolescents, are we aware of their relevance?

Forkert

Rendo-Urteaga

Nascimento-Ferreira

et al. 2016

Nutrire

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Obesity prevalence has increased worldwide over the last decades and has reached alarming rates in low middleincome countries. Childhood has been affected by this epidemic, leading to premature dramatic health problems. Adipose tissue is currently considered as an endocrine organ modulating an inflammatory state and important metabolic processes (insulin resistance, hypertension, glucose intolerance) leading to consequences of the cardiovascular system. This situation may be worst if the excess of body fat distribution such as abdominal obesity (AO) is involved because it is associated with a more atherogenic risk profile determining the cardiometabolic risks mainly in children and adolescents. Hence, the knowledge regarding the association between AO and cardiometabolic factors aims to prevent and treat the obesity in this young population, avoiding early harmful consequences of adulthood health.

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Section: Lipid Abnormalitiesmentioning

confidence: 99%

Abdominal obesity and cardiometabolic risk in children and adolescents, are we aware of their relevance?

Forkert

Rendo-Urteaga

Nascimento-Ferreira

et al. 2016

Nutrire

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“…1 In the Quebec Cardiovascular Study, for every 10% reduction in HDL, risk for CAD increased 13%. 2 Many clinicians believe that low HDL is associated with increased CAD risk because it is a marker for hypertriglyceridemia and elevated remnant particle concentrations. The Prospective Cardiovascular Münster Study, however, demonstrated that the increased risk associated with low HDL is independent of serum triglyceride levels.…”

Section: Hdl As An Independent Risk Factor For Cadmentioning

confidence: 99%

High-Density Lipoprotein and Cardiovascular Risk

Tóth¹

2004

Circulation

120

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L ow serum levels of highdensity lipoprotein (HDL) are commonly encountered in patients with coronary artery disease (CAD). An example of this type of patient is a 42-year-old white man with a history of sudden-onset angina secondary to a 90% obstructive lesion along the proximal left anterior descending coronary artery. The family history was significant for his father, who died of a myocardial infarction (MI) at age 44 years. The patient underwent percutaneous transluminal angioplasty with stenting but developed in-stent restenosis. He underwent cutting balloon angioplasty and brachytherapy and was asymptomatic for approximately 6 months. The stent then developed a high-grade occlusion with recurrence of angina, and the patient required single-vessel bypass surgery.The patient's baseline serum lipid profile revealed low-density lipoprotein (LDL) 128 mg/dL, HDL 27 mg/dL, and triglycerides 92 mg/dL. His lipoprotein(a), C-reactive protein, and homocysteine levels were normal. He was not hypertensive, had no impairment of glycemic control, and did not smoke. With a combination of simvastatin 40 mg and niacin (Niaspan; Kos Pharmaceuticals) 1000 mg daily, the patient's lipid profile improved, with LDL 78 mg/dL, HDL 43 mg/dL, and triglycerides 60 mg/dL. Follow-up stress testing demonstrated normal myocardial perfusion, and the patient has been asymptomatic for 2 years. HDL as an Independent Risk Factor for CADWith few exceptions, low HDL is an independent risk factor for CAD in case-control and prospective observational studies. In contrast, high HDL levels are associated with longevity and are protective against the development of atherosclerotic disease. In the Framingham Study, risk for CAD increases sharply as HDL levels fall progressively below 40 mg/dL. 1 In the Quebec Cardiovascular Study, for every 10% reduction in HDL, risk for CAD increased 13%. 2 Many clinicians believe that low HDL is associated with increased CAD risk because it is a marker for hypertriglyceridemia and elevated remnant particle concentrations. The Prospective Cardiovascular Münster Study, however, demonstrated that the increased risk associated with low HDL is independent of serum triglyceride levels. 3 In the United States, low HDL is present in 35% of men and 15% of women. 4 Given the evolving epidemic of obesity, diabetes mellitus, and metabolic syndrome, the prevalence of low HDL will continue to rise. In one study, low HDL occurred in approximately 63% of patients with CAD. 5 Low HDL is associated with increased risk for MI, stroke, sudden death, restenosis after angioplasty, and severe premature atherosclerotic disease in the proximal left main coronary artery. 6 -9 In one autopsy series, the average total cholesterol:HDL ratio and HDL level in men who died suddenly during exertion were 8.2 and 36 mg/dL, respectively. 10

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“…4,5 In contrast, high density lipoprotein (HDL) cholesterol was found to inversely related to the cardiovascular risk in non-CKD population. 6 End-stage renal disease (ESRD) patients usually have increased concentrations of triglyceride-rich lipoproteins and reduced serum levels of HDL-cholesterol. However, low-density-lipoprotein (LDL) cholesterol values were found to be within normal limits or reduced in this population.…”

Section: Introductionmentioning

confidence: 99%

The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients

Erdur¹,

Tonbul²,

Özbiner

et al. 2013

Renal Failure

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HDL-cholesterol as a marker of coronary heart disease risk: the Québec cardiovascular study

Cited by 290 publications

References 62 publications

Abdominal obesity and cardiometabolic risk in children and adolescents, are we aware of their relevance?

Abdominal obesity and cardiometabolic risk in children and adolescents, are we aware of their relevance?

High-Density Lipoprotein and Cardiovascular Risk

The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients

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