“…These data suggest that UPA may induce leiomyoma shrinkage through an anti-angiogenic mechanism [14] . Conversely, numerous degenerative changes do take place habitually in uterine leiomyoma, such as hyaline, hydropic, myxoid, red, cotyledonoid, and dystrophic calcification [23,24] .These changes are thought to be the consequence of relative ischemia involving regions of the myoma [24][25][26] . The apparition of edema in these tumors is considered to be an additional degenerative process, often referred to as hydropic degeneration.…”