HDR-¹⁹²Ir intraluminal brachytherapy in treatment of malignant obstructive jaundice

Abstract

AIM:To determine the feasibility and safety of intraluminal brachytherapy in treatment of malignant obstructive jaundice (MOJ) and to evaluate the clinical effect of intraluminal brachytherapy on stent patency and patient survival. METHODS:Thirty-four patients with MOJ were included in this study. Having biliary stent placed, all patients were classified into intraluminal brachytherapy group (group A, n = 14) and control group (group B, n = 20) according to their own choice. Intraluminal brachytherapy regimen included:

High dose chemoradiation for unresectable hilar cholangiocarcinomas using intensity modulated external beam radiotherapy: a single tertiary care centre experience

“…The MOS of 17.5 and 16 months achieved in group 1 and 2 respectively was similar to the studies delivering similar doses of radiation. EBBT alone is also shown to prolong the stent patency rate (17). In practice, several patients may fail to be subsequently fit for EBRT or palliative chemotherapy after biliary stenting.…”

Comparison of external beam radiation and brachytherapy to external beam radiation alone for unresectable extrahepatic cholangiocarcinoma

“…Several retrospective series have shown a progression-free and overall survival benefit with the addition of brachytherapy to EBRT (13)(14)(15)(16)(17). One of the proposed mechanisms in these small studies was felt to be secondary to increasing longevity of stent patency (17,24). Stent patency can also enhance patients' tolerability to chemotherapy by decreasing bilirubin levels (25).…”

Imaging and interventions in hilar cholangiocarcinoma: A review

“…The iridium-192 strands are intraluminally placed at the site of the tumor or stricture through PTBD catheter. Chen et al [59] , found 98% success rate of intraluminal brachytherapy using Iridium-192 in 34 patients of malignant biliary obstruction and concluded that intraluminal brachytherapy is a safe palliative therapy and improves patient survival. In photodynamic therapy, a photosensitizer is injected intravenously followed by application of light to the tumor, endoscopically or through PTBD route.…”