Head activator acts as an autocrine growth factor for NH15-CA2 cells in the G2/mitosis transition.

Schaller, Heinz; Druffel-Augustin, Silke; Dübel, Stefan

doi:10.1002/j.1460-2075.1989.tb08492.x

“…Coelenterates (Schaller et al 1989(Schaller et al , 1996Bosch 1998;Grimmelikhuizen et al 1992), planarians (Brøndsted 1969;Kurabuchi and Kishida 1988;Baguña1998), annelids (Chandebois 1976;Chapron 1973;Chapron and Chapron 1976;Coulon and Thouveny 1984;Boilly and Boilly-Marer 1995;Moffett 1996), molluscs (Chetail 1963;Féral 1978aFéral , 1978bGhirardi et al 1996;Sonetti et al 1999), arthropods (O'Farrell andStock 1953;Needham 1965;Bullière et al 1976;Truby 1985), and, possibly, protochordates (Bollner et al 1995), all provide fascinating examples of putative neurotrophic regulation of regeneration. A number of authors have highlighted the primary role of certain neurotransmitters, monoamines, in invertebrate regeneration, and the involvement of these molecules has also been explored in echinoderms (Huet 1975;Franquinet 1979;Franquinet and Catania 1979;Franquinet and Le Moigne 1979;Huet and Franquinet 1981;Candia Carnevali et al 1989, 1996.…”

Section: The Nervous System and Regenerationmentioning

confidence: 99%

Regeneration neurohormones and growth factors in echinoderms

Thorndyke¹,

Carnevali²

2001

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“…Endogenous opioids were detected in the external granular layer (Zagon et al, 1985), and the number of mitoses was increased by the opioid antagonist and decreased by met-enkephalin (Zagon and McLaughlin, 1987). In contrast to this example, neuropeptide expression is usually restricted to postmitotic cells (Marti et al, 1987) and thus it seems that neuropeptides, which have been shown to stimulate the proliferation of non-neuronal cells (Zachary et al, 1987), are not involved in an autocrine control of neuronal proliferation (but see Schaller et al, 1989).…”

Section: Negative Control Of Neuronal Proliferationmentioning

confidence: 99%

The Role of Growth Factors in the Control of Neurogenesis

Rohrer

¹

1990

Eur J of Neuroscience

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“…Coelenterates (Schaller et al 1989(Schaller et al , 1996Bosch 1998;Grimmelikhuizen et al 1992), planarians (Brøndsted 1969;Kurabuchi and Kishida 1988;Baguña1998), annelids (Chandebois 1976;Chapron 1973;Chapron and Chapron 1976;Coulon and Thouveny 1984;Boilly and Boilly-Marer 1995;Moffett 1996), molluscs (Chetail 1963;Féral 1978aFéral , 1978bGhirardi et al 1996;Sonetti et al 1999), arthropods (O'Farrell andStock 1953;Needham 1965;Bullière et al 1976;Truby 1985), and, possibly, protochordates (Bollner et al 1995), all provide fascinating examples of putative neurotrophic regulation of regeneration. A number of authors have highlighted the primary role of certain neurotransmitters, monoamines, in invertebrate regeneration, and the involvement of these molecules has also been explored in echinoderms (Huet 1975;Franquinet 1979;Franquinet and Catania 1979;Franquinet and Le Moigne 1979;Huet and Franquinet 1981;Candia Carnevali et al 1989, 1996.…”

Section: The Nervous System and Regenerationmentioning

confidence: 99%

Regeneration neurohormones and growth factors in echinoderms

Thorndyke¹,

Carnevali²

2001

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There has been much recent interest in the presence and biological functions of growth regulators in invertebrates. In spite of the different distribution patterns of these molecules in different phyla (from molluscs, insects, and annelids to echinoderms and tunicates), they seem always to be extensively involved in developmental processes, both embryonic and regenerative. Echinoderms are well known for their striking regenerative potential and many can completely regenerate arms that, for example, are lost following self-induced or traumatic amputation. Thus, they provide a valuable experimental model for the study of regenerative processes from the macroscopic to the molecular level. In crinoids as well as probably all ophiuroids, regeneration is rapid and occurs by means of a mechanism that involves blastema formation, known as epimorphosis, where the new tissues arise from undifferentiated cells. In asteroids, morphallaxis is the mechanism employed, replacement cells being derived from existing tissues following differentiation and (or) transdifferentiation. This paper focuses on the possible contribution of neurohormones and growth factors during both repair and regenerative processes. Three different classes of regulatory molecules are proposed as plausible candidates for growth-promoting factors in regeneration: neurotransmitters (monoamines), neuropeptides (substance P, SALMFamides 1 and 2), and growth-factor-like molecules (TGF-β (transforming growth factor β), NGF (nerve growth factor), RGF-2 (basic fibroblast growth factor)).Résumé : La présence et le fonctionnement biologique des régulateurs de croissance chez les invertébrés suscitent actuellement un grand intérêt. En dépit des patterns différents de répartition de ces molécules parmi les phylums (des mollusques, insectes et annélides aux échinodermes et aux tuniciers), celles-ci semblent jouer un rôle important dans les processus de développement, aussi bien au cours de l'embryogenèse que de la régénération. La capacité de régénération remarquable des échinodermes est un phénomène connu. Les échinodermes peuvent se refaire des membres entiers perdus, par exemple, par autotomie ou par amputation traumatique. Les échinodermes constituent ainsi un modèle expérimental précieux pour l'étude des processus de régénération, tant à l'échelle macroscopique qu'à l'échelle moléculaire. Chez les crinoïdes, et probablement aussi chez tous les ophiuroïdes, la régénération est rapide et se fait grâce à un mécanisme d'épimorphose qui implique la formation d'un blastème et au cours duquel les nouveaux tissus naissent de cellules non différenciées. Chez les astéroïdes, le mécanisme de régénération est la morphallaxie dans laquelle les cellules de remplacement se forment à partir de tissus existants après différenciation et (ou) transdifférenciation. Nous voulons souligner ici la contribution possible des neurohormones et des facteurs de croissance au cours des processus de réparation et de régénération. Trois classes de molécules régulatrices sont des candidats plausi...

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Head activator acts as an autocrine growth factor for NH15-CA2 cells in the G2/mitosis transition.

Cited by 17 publications

References 20 publications

Regeneration neurohormones and growth factors in echinoderms

Regeneration neurohormones and growth factors in echinoderms

The Role of Growth Factors in the Control of Neurogenesis

Regeneration neurohormones and growth factors in echinoderms

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