Head and neck cancer

Cognetti, David M.; Weber, Randal S.; Lai, Stephen Y.

doi:10.1002/cncr.23654

Cited by 219 publications

(104 citation statements)

References 215 publications

(228 reference statements)

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“…1 However, survivors are susceptible to an increased risk of stroke in the long term attributed to occlusive radiation vas-culopathy (ORV). 2 In head-and-neck cancer cohorts, stroke risks in patients exceeded risks in comparable healthy populations by 2 to 9 times.…”

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confidence: 99%

Angiographic Features, Collaterals, and Infarct Topography of Symptomatic Occlusive Radiation Vasculopathy

Zou

Leung

et al. 2013

Stroke

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Background and Purpose Occlusive radiation vasculopathy (ORV) predisposes head-and-neck cancer survivors to ischemic strokes. Methods We analyzed the digital subtraction angiography acquired in 96 patients who had first-ever transient ischemic attack or ischemic strokes attributed to ORV. Another age-matched 115 patients who had no radiotherapy but symptomatic high-grade (>70%) carotid stenoses were enrolled as referent subjects. Digital subtraction angiography was performed within 2 months from stroke onset and delineated carotid and vertebrobasilar circulations from aortic arch up to intracranial branches. Two reviewers blinded to group assignment recorded all vascular lesions, collateral status, and infarct pattern. Results ORV patients had less atherosclerotic risk factors at presentation. In referent patients, high-grade stenoses were mostly focal at the proximal internal carotid artery. In contrast, high-grade ORV lesions diffusely involved the common carotid artery and internal carotid artery and were more frequently bilateral (54% versus 22%), tandem (23% versus 10%), associated with complete occlusion in one or both carotid arteries (30% versus 9%), vertebral artery (VA) steno-occlusions (28% versus 16%), and external carotid artery stenosis (19% versus 5%) (all P<0.05). With comparable rates of vascular anomaly, ORV patients showed more established collateral circulations through leptomeningeal arteries, anterior communicating artery, posterior communicating artery, suboccipital/costocervical artery, and retrograde flow in ophthalmic artery. In terms of infarct topography, the frequencies of cortical or subcortical watershed infarcts were similar in both groups. Conclusions ORV angiographic features and corresponding collaterals are distinct from atherosclerotic patterns at initial stroke presentation. Clinical decompensation, despite more extensive collateralization, may precipitate stroke in ORV.

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confidence: 99%

Angiographic Features, Collaterals, and Infarct Topography of Symptomatic Occlusive Radiation Vasculopathy

Zou

Leung

et al. 2013

Stroke

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“…It is the sixth most common cancer in the world, affecting over 500,000 people. In the United States it accounts for more deaths annually than cervical cancer, malignant melanoma, or Hodgkin lymphoma [1, 2]. HNSCC refers to a collection of squamous cell carcinomas that arise from the upper aerodigestive tract epithelium, mainly the lip, oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx.…”

Section: Squamous Cell Carcinoma Of the Head And Neckmentioning

confidence: 99%

“…Stage I/II cancers have a good prognosis and have been treated successfully with single modalities. Therefore, the treatment of choice is surgery or radiation [1, 8]. …”

Section: Traditional Treatments and Advancesmentioning

confidence: 99%

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Immunological Treatment Options for Locoregionally Advanced Head and Neck Squamous Cell Carcinoma

Schutt

Bumm

Mirandola

et al. 2012

International Reviews of Immunology

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Patients with squamous cell carcinoma of the head and neck (HNSCC) are usually treated by a multimodal approach with surgery and/or radiochemotherapy as the mainstay of local–regional treatment in cases with advanced disease. Both chemotherapy and radiation therapy have the disadvantage of causing severe side effects, while the clinical outcome of patients diagnosed with HNSCC has remained essentially unchanged over the last decade. The potential of immunotherapy is still largely unexplored. Here the authors review the current status of the art and discuss the future challenges in HNSCC treatment and prevention.

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“…Estimam-se, para o ano de 2016, 11.140 casos novos de câncer da cavidade oral em homens e 4.350 em mulheres (INCA, 2015) e aproximadamente 90% das neoplasias malignas em região de cabeça e pescoço são diagnosticadas como carcinoma epidermoide (CEC) (Argiris et al, 2008;Cognetti et al, 2008).…”

Section: Revisão Da Literaturaunclassified

Detecção dos herpesvirus humanos na mucosa oral de pacientes irradiados para tratamento de carcinoma epidermoide em região de cabeça e pescoço

Palmieri¹

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Palmieri M. Detecção dos herpesvirus humanos na mucosa oral de pacientes irradiados para tratamento de carcinoma epidermoide em região de cabeça e pescoço. Dissertação apresentada à Faculdade de Odontologia da Universidade de São Paulo, para obter o título de Mestre, pelo Programa de Pós-Graduação em Ciências Odontológicas. A radioterapia para tratamento das neoplasias malignas em região de cabeça e pescoço é acompanhada de diversas complicações, decorrentes do comprometimento dos tecidos radiossensíveis localizados próximos ao tumor.Entre essas complicações a mucosite é a que merece maior destaque. A mucosite é uma reação tóxica inflamatória da mucosa oral causada pelo tratamento citorredutivo induzido pela radioterapia (RT) ou pela quimioterapia (QT). Ela manifesta-se com sinais de edema, eritema, úlcera e formação pseudomembrana, resultando em sintomas de ardência, que pode progredir para dor intensa e consequente prejuízo na alimentação e comunicação verbal.Infecções bacterianas, fúngicas ou virais podem acometer a mucosa bucal irradiada e exacerbar a manifestação da mucosite oral por meio da ativação de fatores de transcrição da resposta inflamatória. Existem poucos dados na literatura sobre a participação dos herpesvirus humanos na mucosite oral induzida pela radioterapia. A proposta desse trabalho foi avaliar a excreção oral dos herpesvirus humanos (HSV-1, HSV-2, EBV, CMV, VZV, HHV6, HHV7 e HHV8) e sua possível associação com o desenvolvimento e agravamento da mucosite oral, em pacientes diagnosticados com carcinoma epidermoide (CEC)de boca e orofaringe, submetidos à radioterapia associado à quimioterapia.Nesse estudo foram analisadas 158 amostras de lavado bucal, de 20 pacientes, submetidos à radioterapia para CEC em região de cabeça e pescoço, coletadas semanalmente, durante todo o tratamento. Foi realizada a extração do DNA dessas amostras e em seguida sua amplificação através da PCR utilizando dois conjuntos de primers: HSVP1/P2 para os subtipos HSV-1, HSV-2, EBV, CMV e HHV-8 e o VZVP1/P2 para os subtipos VZV, HHV-6 e HHV-7. As amostras positivas foram submetidas à digestão enzimática com enzimas de restrição BamHI e BstUI para determinação específica de cada um dos oito herpesvirus. Foi também avaliada clinicamente, a mucosite oral, em cada uma das coletas, seguindo os critérios da OMS e NCIC. As análises da amostra mostraram a excreção do EBV, HHV-6 e HHV-7, em todas as semanas de tratamento radioterápico, enquanto que a excreção do HSV1 não pode ser observada no momento da triagem. Considerando-se todos os períodos em conjunto (Triagem, semanas On our study, we analyzed 158 oral rinsing samples, collected weekly, from 20 patients during the whole radiotherapy treatment for squamous cell carcinoma in head and neck. From these samples, we extracted the DNA and afterwards we amplified them with PCR using two sets of primers:HSVP1/P2 for the subtypes HSV-1, HSV-2, EBV, CMV, and HHV-8 and VZVP1/P2 for the subtypes VZV, HHV 6, and HHV-7. The positive samples were subjected to enzymatic digestion with Ba...

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Head and neck cancer

Cited by 219 publications

References 215 publications

Angiographic Features, Collaterals, and Infarct Topography of Symptomatic Occlusive Radiation Vasculopathy

Angiographic Features, Collaterals, and Infarct Topography of Symptomatic Occlusive Radiation Vasculopathy

Immunological Treatment Options for Locoregionally Advanced Head and Neck Squamous Cell Carcinoma

Detecção dos herpesvirus humanos na mucosa oral de pacientes irradiados para tratamento de carcinoma epidermoide em região de cabeça e pescoço

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