Head and neck cancer in a developing country: A population-based perspective across 8years

Attar, Esra; Dey, Subhojit; Hablas, Ahmad; Seifeldin, Ibrahim A.; Ramadan, Mohamed; Rozek, Laura S.; Soliman, Amr S.

doi:10.1016/j.oraloncology.2010.05.002

Cited by 92 publications

(79 citation statements)

References 26 publications

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“…This risk factor seems to be related to exposure to an intermediate metabolite of ethanol, acetaldehyde, which is a known carcinogen 20 . When analyzing the socio-demographic profile of the patients included in this study, a higher prevalence of cancer diagnoses and deaths was observed amongst males, which was also reported in other studies [23][24][25] . There is evidence that exposure to tobacco is higher in men than in women 26 , and that women notice the symptoms of the disease more easily than men, which may lead them to seek medical assistance earlier 23 , thus resulting in earlier diagnosis and improved survival.…”

Section: Discussionsupporting

confidence: 85%

Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

Schneider

Flores

Nickel

et al. 2014

Rev. bras. epidemiol.

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Introduction: Cancer of the lip, mouth and pharynx is a serious health problem. High incidence rates are found worldwide. In Brazil, the Southern and Southeastern regions have the highest incidences in the country. Objective: To describe 5 and 10-year survival rates in patients with cancer of the lip, mouth and pharynx at a referral center in Florianopolis, Santa Catarina, Brazil. Methods: Retrospective cohort study using data from patients diagnosed between January 1 st and December 31 st , 2001, with follow-up until December 31 st , 2011. Descriptive analysis was performed and survival was estimated by Kaplan-Meier method. Cox semiparametric model was used to estimate death risk. Results: Survival rates at 5 and 10 years were 33.3 and 26.9%, respectively. Advanced clinical stage in the diagnosis increased death risk by 2.88 and 2.51, respectively. Sex, ethnicity, level of education, previous diagnosis and treatment, as well as age, did not show significant association. Conclusion: Survival rate at 5 years was 33.3% and, at 10 years, was 26.9%. Advanced stage was an independent risk factor for death due to cancer of the lip, mouth and pharynx in both periods analyzed.

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Section: Discussionsupporting

confidence: 85%

Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

Schneider

Flores

Nickel

et al. 2014

Rev. bras. epidemiol.

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“…Similar findings found in another studies where, mean age of patients was 52.6 years and 59.5 years respectively. 1,14 All the above studies reported predominance of carcinoma tongue in males which is consistent with our findings.…”

Section: 11supporting

confidence: 93%

Relation between the depth of tumor and neck node metastasis in early carcinoma of tongue

Kshirsagar

Manerikar

2018

Int Surg J

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INTRODUCTIONTongue squamous cell carcinoma (TSCC) is one of the commonest cancers within the oral cavity. Incidence of tongue cancer in India is second highest in the world. 1 TSCC is significantly more aggressive than other forms of oral cancer, with a high propensity of local invasion and spread, and a high recurrence rate.1,2 It has been reported that 40% of all TSCC patients have neck metastasis at the time of diagnosis.3 Patients with earlystage TSCC (T1/T2N0) showed occult nodal metastasis in approximately 20-40% cases. 4 The survival in carcinoma of the tongue is poor compared to other sub-sites in oral cavity.5 It has characteristic ABSTRACT Background: Tongue squamous cell carcinoma (TSCC) is one of the aggressive forms of oral cancer with a high recurrence rate. Forty percentages of all TSCC patients have neck metastasis at the time of diagnosis. The status of cervical lymph nodes at presentation is the single most important prognostic factor in TSCC. This study was focused on establishing relation between the tumor depth and neck node metastasis in carcinoma of tongue. Authors accessed the patterns of cervical node metastasis in it. Methods: prospective non-randomised study of 100 patients was carried out. After detail clinical history punch biopsy were taken from the tongue lesion. Biopsy proven cases of early squamous cell carcinoma (T1/T2) with clinically negative neck (cN0) were included in this study. Ultra-sonography of the tongue using 7.5 MHz probe was performed in all cases to know the depth of lesion. Final histopathological findings i.e. pT, pN, differentiation and depth of invasion were compared with pre-operative clinical and radiological findings. Results: Out of 100 patients, 62 were males and 38 were females. Clinically 56 patients were belonged to T2. Ultrasonography of tumor had high sensitivity and specificity. Node positivity increased with the depth of primary tumor. On histopathological examination, positive node observed in total 25 patients. Number of occult neck node positivity raised with increased size of primary tumor. i.e. 15% and 31% with pT1 and pT2, respectively. Level II was the most common site for cervical node involvement followed by level III. Conclusions: Ultra-sonography was a reliable tool to access the depth of tumor pre-operatively in the cases of tongue carcinoma patients with sensitivity and specificity more than 90%. Node positivity increased with the depth of primary tumor. Tumor thickness is a significant predictor of nodal metastasis and elective neck dissection should be decided accordingly.

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“…This indicates that environmental factors may play a vital role in the pathogenesis of HNC (Attar et al, 2010).…”

Section: Common Risk Factors For Hncmentioning

confidence: 99%

Incidence and Mortality from Mucosal Head and Neck Cancers amongst Australian States and Territories: What It Means for the Northern Territory

Singh¹,

Jayaraj²,

Baxi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Mucosal head and neck cancers are squamous cell carcinomas that develop in the upper-aero digestive epithelium. Together they constitute the sixth most common cancer with an estimated 900,000 new cases and 350,000 deaths each year reported worldwide. The risk factors are tobacco, alcohol and human papillomavirus (HPV). Our research team initially reported a high incidence rate of HNC in the indigenous population of the Northern Territory. Mortality rates also vary in the Australian States and Territories, with particularly high mortality observed in the Northern Territory. There is a paucity of incidence studies of HNC for the Australian States and Territories. Therefore this review primarily focuses on variation in incidence and mortality iacross the country and highlights specifically the high incidence and mortality in the Northern Territory. Attention is also given to sex-specific incidence and mortality rates .Keywords: Head and neck cancer -incidence rate -international classification disease -mortality rate -risk factors

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Head and neck cancer in a developing country: A population-based perspective across 8years

Cited by 92 publications

References 26 publications

Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

Relation between the depth of tumor and neck node metastasis in early carcinoma of tongue

Incidence and Mortality from Mucosal Head and Neck Cancers amongst Australian States and Territories: What It Means for the Northern Territory

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