Head and Neck Cancer in World Trade Center Responders

Graber, Judith M.; Chuang, Connie T; Ward, Carolyn; Black, Kathleen; Udasin, Iris

doi:10.1097/jom.0000000000001386

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Consequentially, cancer research accounts for a large portion (21%) of the funds awarded. There are descriptive and analytic studies examining cancer mortality and incidence, with a few studies examining mechanisms or treatment [ 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ]. There are also notable reviews [ 77 , 78 ].…”

Section: Research Portfoliomentioning

confidence: 99%

World Trade Center Health Program: First Decade of Research

Santiago-Colón

Daniels

Reissman

et al. 2020

IJERPH

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The terrorist attacks on 11 September 2001 placed nearly a half million people at increased risk of adverse health. Health effects research began shortly after and continues today, now mostly as a coordinated effort under the federally mandated World Trade Center (WTC) Health Program (WTCHP). Established in 2011, the WTCHP provides medical monitoring and treatment of covered health conditions for responders and survivors and maintains a research program aimed to improve the care and well-being of the affected population. By 2020, funds in excess of USD 127 M had been awarded for health effects research. This review describes research findings and provides an overview of the WTCHP and its future directions. The literature was systematically searched for relevant articles published from 11 September 2001 through 30 June 2020. Synthesis was limited to broad categories of mental health, cancer, respiratory disease, vulnerable populations, and emerging conditions. In total, 944 WTC articles were published, including peer-reviewed articles funded by the WTCHP (n = 291) and other sources. Research has focused on characterizing the burden and etiology of WTC-related health conditions. As the program moves forward, translational research that directly enhances the care of individuals with chronic mental and physical health conditions is needed.

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Section: Research Portfoliomentioning

confidence: 99%

World Trade Center Health Program: First Decade of Research

Santiago-Colón

Daniels

Reissman

et al. 2020

IJERPH

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“…A significant excess of HNC had not been previously identified among the WTC‐exposed cohorts; an SIR for oropharyngeal cancer was reported in the WTCHP GRC in 2008 of 1.21 (95% CI: 0.75, 1.86) . However, an apparent unusually high number of head and neck cancers (HNC) among WTC‐exposed patients has been reported by clinicians . It is biologically plausible that HNC cancer incidence may be attributable to the WTC exposures for several reasons: i) the dust composition; ii) the main route of exposure being inhalation; and, iii) the high exposure intensity in the first days after the towers’ collapse.…”

Section: Introductionmentioning

confidence: 99%

Excess HPV‐related head and neck cancer in the world trade center health program general responder cohort

Graber

Harris

Black

et al. 2019

Intl Journal of Cancer

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The World Trade Center (WTC) attacks exposed rescue and recovery workers to a complex mix of toxicants, including carcinogens. our study compared site-specific cancer incidence of head and neck cancers (HNC) from 2003 through 2012 among 33,809 consented WTC General Responder Cohort (GRC) members to the New Jersey State Cancer Registry, using standardized incidence ratios (SIRs). HNC grouped using SEER ICD-O-3 codes into HPV-related (oropharyngeal) and non-related (other oral-nasal; laryngeal) tumors based on anatomical site. For the 73 GRC members identified with HNC, proportional hazard regression assessed the relationship between WTC exposure and other socio-demographic characteristics. An overall excess of HNC was not observed (SIR = 1.00, 95% CI: 0.78, 1.25) but excess cancer was seen in the latest observation period (2009-2012: SIR = 1.4; 95% CI: 1.01, 1.89). A similar temporal pattern was seen for HPV-related oropharyngeal cancer and laryngeal cancer, but not for non-HPV-related sites (oral-nasal cancer). HNC was significantly associated with increasing age (8% per year, 95% CI: 5%, 12%), non-Hispanic white ethnic group-ethnicity (hazard ratio (HR) = 3.51, 95 CI: 1.49, 8.27); there was a borderline association with the 9/11 occupation of military/protective services vs. others (HR = 1.83 95% CI: 0.99, 3.38; p = 0.0504). Caution is needed in interpreting these results given the small number of cases, potential for surveillance bias, and long latency for most cancers. Our findings highlight the need to examine the potentially carcinogenic effects of WTC exposure in the context of other strong risk factors, and the need for continued medical monitoring of WTC responders.

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Head and Neck Cancer in World Trade Center Responders

Cited by 2 publications

References 27 publications

World Trade Center Health Program: First Decade of Research

World Trade Center Health Program: First Decade of Research

Excess HPV‐related head and neck cancer in the world trade center health program general responder cohort

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