Head and Neck Cancer in CNonsmokers: A Distinct Clinical and Molecular Entity

Koch, Wayne M.; Lango, Miriam; Sewell, David L.; Zahurak, Marianna; Sidransky, David

doi:10.1097/00005537-199910000-00002

Cited by 237 publications

(247 citation statements)

References 16 publications

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“…p53 mutation is common in OSCC of smokers, but less often detected in carcinomas of those who never smoked. Loss of heterozygosity at selected microsatellite loci is more frequent in OSCC of smokers than in non-smokers (Koch et al, 1999). However, our data show no significant correlation between smoking history and either Pidd expression or AI.…”

Section: Correlation Of Pidd Expression With Clinical Datacontrasting

confidence: 67%

The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma

et al. 2007

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The Pidd (p53-induced protein with death domain) gene was shown to be induced by the tumour suppressor p53 and to mediate p53-dependent apoptosis in mouse and human cells, through interactions with components of both the mitochondrial and the death receptor signalling pathways. To study the role of Pidd in clinical tumours, we measured its expression by quantitative reverse transcription-PCR in microdissected oral squamous cell carcinomas (OSCC) with and without p53 mutation. Tumour cell apoptosis was assessed by in situ terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling. Tumour proliferation was assessed by immunohistochemical staining for the Ki-67 antigen. We found a wide range of Pidd expression among OSCC. Statistical analysis revealed an association between Pidd expression and apoptotic index (Mann -Whitney test, Po0.001), consistent with a role of Pidd in apoptosis in this tumour type. Furthermore, we showed a positive correlation between apoptotic index and proliferative index that has not been previously described for OSCC. There was no correlation between Pidd expression and the p53 mutation status of these tumours, suggesting that Pidd expression may be regulated by p53-independent mechanisms. Further characterisation of these molecular defects in the control of proliferation and apoptosis should help in developing treatments that target OSCC according to their biological properties.

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Section: Correlation Of Pidd Expression With Clinical Datacontrasting

confidence: 67%

The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma

et al. 2007

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“…In 1932, Warren and Gates (97) suggested the possibility of a genetic predisposition or susceptibility in some individuals to the development of head and neck cancer. The sporadic occurrence of SCC in young adults and in nonusers of tobacco and alcohol suggests the possibility of genetic predisposition (98), although more recent studies suggest that in comparison to tumors of smokers, the tumors of nonsmokers contain a lower frequency of genetic alterations (99). Additional evidence for a genetic basis of carcinogenesis for HNSCC includes the presence of chromosomal alterations, including deletions, rearrangements, amplifications, and overexpressions in head and neck cancer (83) and mutagen-induced chromosomal fragility (100 -107).…”

Section: Genetics Of Hnsccmentioning

confidence: 99%

Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants

Wenig

2002

Modern Pathology

120

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“…However, while a fraction of HNSCC (7%) may be attributable only to alcohol drinking [9], information in alcohol habits is missing in those studies. Moreover, some studies excluded elderly people [7], which represent another well-established subgroup of NSND with OSCC [2,10].…”

Section: Introductionmentioning

confidence: 99%

The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade

et al. 2017

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To cite this version:P. Foy, Chloé Bertolus, Marie-Cécile Michallet, Sophie Deneuve, R. Incitti, et al.. The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade. Annals of Oncology, Oxford University Press (OUP), 2017, 28 (8), pp.1934-1941 Background: Never-smokers and never-drinkers patients (NSND) suffering from oral

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Head and Neck Cancer in CNonsmokers: A Distinct Clinical and Molecular Entity

Abstract: The clinical and genetic features of HNSCC are distinct between groups defined by tobacco use. Tumors of nonsmokers contain a lower frequency of common genetic alterations, suggesting that the underlying changes in these tumors may remain undiscovered.

Cited by 237 publications

References 16 publications

The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma

The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma

Squamous Cell Carcinoma of the Upper Aerodigestive Tract: Precursors and Problematic Variants

The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade

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