Head and neck cancer--Part 1: Epidemiology, presentation, and prevention

Mehanna, Hisham; Paleri, Vinidh; West, Catharine M L; Nutting, Chris

doi:10.1136/bmj.c4684

Cited by 261 publications

(259 citation statements)

References 17 publications

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“…Prior to the endoscopic screening, patients underwent face-to-face interviews, physical examinations, and laboratory tests to identify traditional risk factors for SCCs in the head and neck region (24) and in the esophagus (25) that would be used as baseline comparators for the upcoming epigenetic approach. These included: the demographic characteristics (6, 7) of age, sex, and body mass index (BMI); the lifestyle risk factors (8, 9, 11) of alcohol drinking, betel quid chewing, and cigarette smoking (briefly as "ABC"); polymorphisms in genes encoding enzymes involved in the metabolism of alcohol (10-13), including aldehyde dehydrogenase (ALDH) 2, alcohol dehydrogenase (ADH) 1B, and ADH 1C; polymorphisms in genes encoding enzymes involved in the metabolism of xenobiotics (14), including glutathione S transferase (GST) P1, GST M1, and GST T1; and serological markers (15)(16)(17)(18), including increased mean corpuscular volume (MCV), Helicobacter pylori infection, and human papillomavirus infection.…”

Section: Traditional Risk Factorsmentioning

confidence: 99%

Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic Markers

Lee

Wang

et al. 2011

Cancer Prevention Research

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We quantified field cancerization of squamous cell carcinoma in the upper aerodigestive tract with epigenetic markers and evaluated their performance for risk assessment. Methylation levels were analyzed by quantitative methylation-specific PCR of biopsied specimens from a training set of 255 patients and a validation set of 224 patients. We also measured traditional risk factors based on demographics, lifestyle, serology, genetic polymorphisms, and endoscopy. The methylation levels of four markers increased stepwise, with the lowest levels in normal esophageal mucosae from healthy subjects without carcinogen exposure, then normal mucosae from healthy subjects with carcinogen exposure, then normal mucosae from cancer patients, and the highest levels were in cancerous mucosae (P < 0.05). Cumulative exposure to alcohol increased methylation of homeobox A9 in normal mucosae (P < 0.01). Drinkers had higher methylation of ubiquitin carboxyl-terminal esterase L1 and metallothionein 1M (P < 0.05), and users of betel quid had higher methylation of homeobox A9 (P ¼ 0.01). Smokers had increased methylation of all four markers (P < 0.05). Traditional risk factors allowed us to discriminate between patients with and without cancers with 74% sensitivity (95% CI: 67%-81%), 74% specificity (66%-82%), and 80% area under the curve (67%-91%); epigenetic markers in normal esophageal mucosa had values of 74% (69%-79%), 75% (67%-83%), and 83% (79%-87%); and both together had values of 82% (76%-88%), 81% (74%-88%), and 91% (88%-94%). Epigenetic markers done well in the validation set with 80% area under the curve (73%-85%). We concluded that epigenetics could improve the accuracies of risk assessment.

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Section: Traditional Risk Factorsmentioning

confidence: 99%

Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic Markers

Lee

Wang

et al. 2011

Cancer Prevention Research

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“…Each year more than 600,000 new diagnoses are made worldwide, with the most common sites being the oral cavity, the larynx and the pharynx (1). Although outcomes can differ between tumors of the same stage, the prognosis of patients suffering from head and neck cancer is mainly dependent on the tumor stage, particularly the lymph node status.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Polo-like-kinase-1-inhibitor BI2536 in squamous cell carcinoma cell lines of the head and neck

et al. 2012

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Abstract. Inhibition of the Polo-like-kinase-1 (PLK1) has been shown to be effective in a number of solid tumor models. In this in vitro study, we examined the antitumor effect of BI2536, a small molecule inhibitor of PLK1, in squamous cell carcinoma of the head and neck (SCCHN) cell lines. Dose escalation studies were performed with nine SCCHN cell lines using BI2536. Growth inhibitory and proapoptotic effects were measured quantitatively using cytohistology and a Human Apoptosis Array Kit. BI2536 demonstrated a significant antiproliferative and apoptotic activity in all nine SCCHN cell lines investigated (p<0.009). Our results indicate that inhibition of PLK1 by BI2536 leads to an antiproliferative and apoptotic effect in SCCHN cell lines. In vivo and in the clinical setting, the application of BI2536 may support the antitumoral activity of conventional drugs that are in current use and could decrease the systemic toxicity of these drugs.

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“…Los mayores factores de riesgo descritos para desarrollar un cáncer laríngeo son el tabaquismo y el consumo de alcohol, atribuyéndose hasta 75% de efecto. Respecto al tabaco, se ha descrito una mayor asociación en relación al cáncer escamoso de laringe en comparación con otros sitios de CECyC 5,6 . En términos generales, respecto al CECyC, los fumadores activos presentan entre 5 a 25 veces más riesgo de desarrollar esta neoplasia, comparado con no fumadores 15 .…”

Section: Factores De Riesgo Y Prevenciónunclassified

“…También se han sugerido infecciones por virus papiloma humano y factores ambientales, aunque el rol de éstos no está claramente dilucidado aún 5,6 .…”

Section: Introductionunclassified

Importancia de la epidemiología en cáncer laríngeo: Incidencia y mortalidad por carcinoma escamoso de laringe

2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Head and neck cancer--Part 1: Epidemiology, presentation, and prevention

Cited by 261 publications

References 17 publications

Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic Markers

Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic Markers

Effects of the Polo-like-kinase-1-inhibitor BI2536 in squamous cell carcinoma cell lines of the head and neck

Importancia de la epidemiología en cáncer laríngeo: Incidencia y mortalidad por carcinoma escamoso de laringe

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