Head and Neck Lymphoma in Patients with the Acquired Immune Deficiency Syndrome

Shapiro, Aaron L.; Shechtman, Frank G.; Guida, Robert A.; Kimmelman, Charles P.

doi:10.1177/019459989210600311

Cited by 19 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although this malignancy in non-immunocompromised individuals occurs mostly in lymph nodes, in HIV-infected patients it tends to develop in extra-nodal sites, such as in the central nervous system, digestive tract and bone marrow (Bermudez et al, 1989;Ioachim et al, 1991). NHLs of the paranasal sinuses are rare: we have identified only 19 cases of NHL occurring in the paranasal sinuses of HIV-infected patients through a search up to 1996 of English-language articles (we have excluded cases involving the maxillary bone in which there was no apparent sinus involvement) (Leess et al, 1987;Bermudez et al, 1989;Quivey et al, 1989;Schoem and Morton, 1990;Goldstein et al, 1991;Ioachim et al, 1991;Langford et al, 1991;Desai et al, 1992;Rosenthal et al, 1992;Rubin and Sanfilippo, 1992;Shapiro et al, 1992;Shiramizu et al, 1992;Font et al, 1993;Yang and Jayaram, 1993;Pomilla et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin's lymphoma of the maxillary sinus in a patient with acquired immunodeficiency syndrome

et al. 1998

View full text Add to dashboard Cite

Non-Hodgkin's lymphoma (NHL) is one of the most common malignancies in patients infected with human immunodeficiency virus (HIV); it occurs 25–60 times more frequently in HIV-infected patients than in the general population. This neoplasm in acquired immunodeficiency syndrome (AIDS) patients is a highly aggressive tumour with a poor prognosis and tends to develop in extranodal sites, such as the central nervous system, digestive tract and bone marrow. NHL involving the paranasal sinuses is rare in HIV-infected patients, and is likely to be confused clinically and radiographically with sinusitis; moreover, its optimal treatment is currently uncertain.We present a case of NHL involving the left maxillary sinus in a patient with AIDS. The patient was treated with systemic chemotherapy (low dose-CHOP), but the malignancy did not respond. Subsequently, he was treated with local maxillary sinus irradiation which resulted in partial regression of the neoplasm and in decrease of local symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin's lymphoma of the maxillary sinus in a patient with acquired immunodeficiency syndrome

et al. 1998

View full text Add to dashboard Cite

show abstract

“…Die zum Zeitpunkt der Lymphomdiagnosestellung gemessenen CD4-Werte schwankten zwiknoten [16]. Mittlerweile liegen Studien mit größeren Patientenkollektiven von HIV-NHL im Kopf-Hals-Bereich vor [2,4,18]. Laut Carbone treten 38,4% (28/73) der NHL bei AIDS-Patienten in dieser Region auf [2].…”

Section: Ergebnisseunclassified

“…Bei Patienten mit angeborenem oder erworbenem Immundefekt sind vermehrt Malignome zu beobachten [2,13,17,18]. Durch die Entwicklung der damit verbundenen Lymphomproliferation ist die Häufigkeit, an hochmalignen Non-Hodgkin-Lymphomen zu erkranken, erhöht.…”

Section: Diskussionunclassified

“…Neben Candidiasis, Lymphadenopathie und Haarleukoplakie wird der HNOArzt, bedingt durch das längere Über-leben der Infizierten, künftig in zunehmendem Maße auch mit HIVbedingten Malignomen wie dem Kaposi-Sarkom und dem meist als rasch wachsender Tumor imponierenden HIV-NHL konfrontiert werden [4,9,13,18]. Hochmaligne Non-Hodgkin-Lymphome manifestieren sich im KopfHals-Bereich nicht nur in Lymphknoten, sondern können zudem als ulzerö-se oder hyperplastische Schleimhautlä-sionen vorkommen.…”

Section: Schlußfolgerungunclassified

See 1 more Smart Citation

HIV-assoziierte Non-Hodgkin-Lymphome (HIV-NHL) im Kopf-Hals-Bereich

Riederer

Dreher

Zietz

et al. 1997

HNO

View full text Add to dashboard Cite

The life span of HIV-infected patients has increased because of anti-retroviral therapy and improved means for treating opportunistic infections. However, HIV infection and subsequent immunosuppression result in an increased risk of high-grade B-cell lymphomas. The purpose of this study was to determine the incidence, localization, clinical features, therapy and survival time of patients with HIV-related lymphomas of the head and neck. Between 1988 and 1995, 280 HIV-infected patients presented with otolaryngologic symptoms. Seventy-two (25.7%) were found to have a neoplastic disease. Fifty-six of these patients (20%) were diagnosed as having Kaposi's sarcoma and 12 (4.3%) had lymphomas. According to the Kiel classification, lymphomas were subdivided into Hodgkin's disease (2 cases) and B-cell lymphomas of high-grade malignancy (10 cases). These latter cases were centroblastic (n = 4), Burkitt's type (n = 4), anaplastic large cell (n = 1) and not classifiable (n = 1). All patients with HIV-related non-Hodgkin's lymphomas (NHL) were men and 8 were homosexuals. The mean age was 36.1 years. In addition to 7 nodal locations, high-grade B-cell lymphomas were found in the oropharynx (n = 2) and palate (n = 1). Four patients underwent chemotherapy, 1 patient underwent radiation therapy and 2 were treated with both methods. Two patients did not receive any treatment and 1 patient underwent laser therapy. The survival time depended on the previous diagnosis of AIDS, the patients' immune status and the karnofsky index. In 2 patients the lymphoma led to the diagnosis of HIV infection. Our findings show that any solitary or enlarging tumors or ulcerating lesions in the head and neck region of HIV patients must be examined histologically to exclude HIV-NHL. We also recommend that young patients with high-grade B-cell lymphomas should undergo HIV screening.

show abstract

“…According to Lee et al, 8% of HIV patients had fungal sinusitis with nasal polyps. According to Shapiro et al, 5% of HIV patients had nasal polyps 12. Causative organisms include atypical opportunistic organisms as well as agents responsible for sinusitis in hosts without AIDS.…”

mentioning

confidence: 99%

A study on otorhinolaryngologic manifestations in human immunodeficiency virus infected patients

Ashok

Rajendran

2020

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

Background: The main aim of this study was to find out the ear, nose, and throat (ENT) manifestations in a selected regional population of 100 HIV infected patients, to identify the commoner ENT manifestations among them and to make these manifestations, a guide for regional ENT surgeons, to diagnose HIV/AIDS patients early and to treat them accordingly.Methods: The study was a prospective study which was conducted for a period of five years which included 100 HIV seropositive patients, among the patients attending the Outpatient Department of the Otorhinolaryngology and anti-retroviral therapy centre across Government Hospitals in Tamil Nadu according to our inclusion or exclusion criteria. Detailed ENT clinical examination as well as laboratory investigations were carried out to evaluate the nature of ENT presentations of HIV infection. Results: Out of the 100 HIV positive patients, who had some form of ENT symptoms, the most common ENT manifestation in HIV/AIDS was oral candidiasis (40%) followed by cervical lymphadenopathy (30%). Other common manifestations are oral herpes simplex and sensorineural hearing loss. Less common manifestations are chronic sinusitis, tuberculous laryngitis, chronic otitis media, oral hairy leukoplakia, nasal polyps and Kaposi’s sarcoma. Oral candidiasis, chronic/recurrent mucocutaneous herpes simplex, oral hairy leukoplakia and Kaposi’s sarcoma are the AIDS defining illnesses. Oral hairy leukoplakia, is pathognomonic of HIV infection.Conclusions: These manifestations help ENT surgeons, to recognize HIV/AIDS patients from the specific ENT lesions occurring in them, for early diagnosis and subsequent treatment.

show abstract

Head and Neck Lymphoma in Patients with the Acquired Immune Deficiency Syndrome

Cited by 19 publications

References 2 publications

Non-Hodgkin's lymphoma of the maxillary sinus in a patient with acquired immunodeficiency syndrome

Non-Hodgkin's lymphoma of the maxillary sinus in a patient with acquired immunodeficiency syndrome

HIV-assoziierte Non-Hodgkin-Lymphome (HIV-NHL) im Kopf-Hals-Bereich

A study on otorhinolaryngologic manifestations in human immunodeficiency virus infected patients

Contact Info

Product

Resources

About