Head and neck pilomatricoma: an analysis of 201 cases

O’Connor, Niamh; Patel, Manish; Umar, T.; Macpherson, D.W.; Ethunandan, M.

doi:10.1016/j.bjoms.2010.06.002

Cited by 50 publications

(51 citation statements)

References 13 publications

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“…However, pilomatricomas of the ear, especially the antihelix, were rare. Pilomatricoma occurring in the ear has been observed in 0% to 4.5% of previous studies (Agarwal et al, 2001;AlKhateeband and Hamasha, 2007;Danielson-Cohen et al, 2001;Duflo et al, 1998;Lan et al, 2003;O'Connor et al, 2011;Pirouzmanesh et al, 2003). Pilomatricomas in external auditory meatus (Vinayak et al, 1993), helix (Hassanein et al, 2011;Nassie et al, 2007), ear lobe (Rao and Ramnarayan, 1992;Pant et al, 2010;Sevin et al, 1995), and antihelix (Li et al, 2011) have been reported by several authors as rare cases.…”

Section: Discussionmentioning

confidence: 97%

“…These lesions are typically found in the head and neck, particularly cheek, preauricular region, and orbital region, but rarely found in the ear (Agarwal et al, 2001;Al-Khateeband and Hamasha, 2007;Danielson-Cohen et al, 2001;Duflo et al, 1998;Hassanein et al, 2011;Lan et al, 2003;Li et al, 2011;Nassie et al, 2007;O'Connor et al, 2011;Pirouzmanesh et al, 2003;Vinayak et al, 1993). We present a case of a pilomatricoma occurring in the ear antihelix.…”

Section: Introductionmentioning

confidence: 99%

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Pilomatricoma of the Ear Antihelix

Saito¹,

Saito²,

Minakawa³

2013

IJCRM

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Pilomatricoma is a benign neoplasm that differentiates to hair follicle matrix cells. The pilomatricoma of the head and neck region is not uncommon, but it is rare to occur in the ear. We present a case of a 7-month-old male infant with a pilomatricoma of the ear antihelix. Diagnosis of pilomatricoma may be made by clinical findings when the presentation is classic. In the present case, the lesion showed atypical features clinically and it was quite difficult to make preoperative diagnosis. In an atypical case, excisional biopsy is required to obtain a definitive diagnosis.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Pilomatricoma of the Ear Antihelix

Saito¹,

Saito²,

Minakawa³

2013

IJCRM

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“…Pilomatricoma represents a benign neoplasm of trichilemmal differentiation occurring primarily in young patients, although middle-aged adults may be affected as well [20][21][22]. The most common site of involvement is the head and neck [7,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…The most common site of involvement is the head and neck [7,21,22]. Multiple pilomatricomas can be associated with myotonic dystrophy, GS, or Turner and Rubinstein-Taybi syndromes [4][5][6][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Orthokeratinized Odontogenic Cyst with an Associated Keratocystic Odontogenic Tumor Component and Ghost Cell Keratinization and Calcifications in a Patient with Gardner Syndrome

Argyris

Koutlas

2016

Head and Neck Pathol

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Gardner syndrome (GS) is caused by mutations in the APC and besides adenomatous colorectal polyps includes such manifestations as osteomas, epidermoid cysts (ECs) and occasionally multiple pilomatricomas. More than 50 % of ECs in patients with GS exhibit pilomatricoma-like ghost cell keratinization. The latter may be explained by the fact that the development of both GS and pilomatricoma is driven by activation of the Wnt/b-catenin signaling pathway. A 62-year-old, Caucasian male with history of GS presented with a unilocular, mixed radiopaque/radiolucent mandibular lesion causing divergence and external root resorption of involved teeth. Histopathologically, the lesion was composed of two cystic components, an orthokeratinized odontogenic cyst (OOC) and a smaller one with characteristics of keratocystic odontogenic tumor (KCOT) featuring, focally, ghost cells and an epithelial morule-like structure. Dystrophic calcifications essentially similar to those seen in pilomatricomas were observed in the fibrous connective tissue wall. The KCOT and OOC epithelia revealed strong and diffuse cytokeratin (AE1/AE3) and b-catenin immunoreactivity. CD10 positive immunostaining was seen in the keratin and superficial spinous cell layers in both OOC and KCOT. The intraepithelial and mural ghost cells showed a cytokeratin (?), b-catenin and CD10 (-) immunophenotype. The diagnosis of OOC with ghost cell calcifications in association with KCOT was rendered. The patient was lost to follow-up. Although a coincidental co-existence cannot be excluded, ghost cell calcifications mimicking pilomatricoma-like changes in an unusual odontogenic cyst combining OOC and KCOT features as seen in this patient with GS may be explained by the common molecular mechanisms underlying the pathogenesis of cutaneous pilomatricomas and GS.

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“…It was first described by Malherbe and Chenantaisare, who termed the disease "epithelioma of Malherbe, " as they believed it was derived from the sebaceous glands (1,2). Pilomatricomas often present as a asymptomatic, solitary, hard, slow-growing subcutaneous massed, and the overlying skin may occasionally have a bluish discoloration (2). Pilomatricomas are not uncommon and are present in 1 out of every 500 skin specimens submitted to pathologists (3).…”

Section: Introductionmentioning

confidence: 99%