Head and Neck Porocarcinoma: SEER Analysis of Epidemiology and Survival

Abstract

Porocarcinoma is a rare malignant adnexal tumor. Little is known about the location of the disease in the head and neck. Our aim is to offer the largest analysis of demographic, pathological, and treatment patterns of head and neck porocarcinoma in comparison with other locations of the neoplasm from an epidemiologically representative cohort. Method: The Surveillance, Epidemiology, and End Results program of the National Cancer Institute was searched for all cases of porocarcinomas diagnosed between 2000 and 2018. This database is considered representative of the US population. Demographic, pathological, and treatment variables were compared between the head and neck and other regions. Overall and disease-specific survival was calculated and compared between groups. Results: 563 porocarcinomas were identified, with 172 in the head and neck. The mean age was 66.4 years. Males were more affected in the head and neck. Regional and distant invasion rates were low (2.9 and 2.3%, respectively). Local excision and Mohs surgery were the most frequent therapies. Five-year overall survival was 74.8%. Five-year disease-specific survival was 97%. Conclusions: Head and neck porocarcinoma affects more males than females. Regional or distant metastatic rates are low and overestimated in previous literature. Disease-specific mortality is low. Surgery remains the mainstay of treatment.

Intraabdominal dissemination of porocarcinoma; A case report

“…Current literature suggests an otherwise better prognosis. A five-year survival rate of 74.5 % for head and neck porocarcinoma has been reported in the U.S [6] . In Finland, a ten-year retrospective analysis revealed a single porocarcinoma-related death among 69 cases reviewed [9] .…”

“…The first case of porocarcinoma was reported in 1963 by Pinkus and Mehreghan; described as epidemotrophic eccrine carcinoma due to histological epidemotrophism and pagetoid nature [5] . There is an even gender distribution or a slight male predominance [6] , [7] . The disease commonly affects whites and is often diagnosed in the seventh decade of life [6] , [8] , [9] .…”

“…There is an even gender distribution or a slight male predominance [6] , [7] . The disease commonly affects whites and is often diagnosed in the seventh decade of life [6] , [8] , [9] . High radiation dose, prolonged sunlight exposure, immunosuppression, and other pre-existing dermatological pathology are the main risk factors for porocarcinoma [6] .…”

“…The disease commonly affects whites and is often diagnosed in the seventh decade of life [6] , [8] , [9] . High radiation dose, prolonged sunlight exposure, immunosuppression, and other pre-existing dermatological pathology are the main risk factors for porocarcinoma [6] . Although not known, the pathogenesis of porocarcinoma is linked to p53, observed in 83 % of eccrine and 73 % of porocarcinoma [10] .…”

“…Histologically porocarcinoma consists of matured ductal formation and matured intracytoplasmic lumina; other microscopic findings include comedo necrosis, diffuse necrosis, and squamous differentiation [12] . Common sites affected are the lower limbs, scalp, face, neck, and trunk [6] , [7] , [9] . This article is being reported following the SCARE criteria 2020 [13] .…”