Head and neck squamous cell carcinoma in non‐smoking and non‐drinking patients with multiple tumors: etiologic significance of p53 and Ki‐67 in non‐tumorous epithelium

Farshadpour, F.; Hordijk, G. J.; Koole, R.; Slootweg, Pieter J.

doi:10.1111/j.1600-0714.2008.00657.x

Cited by 23 publications

(31 citation statements)

References 25 publications

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“…The majority of studies about p53 in OSCC have focused on protein expression by immunohistochemistry [6,8,9,10,11,17]. Some of these studies [22,23,24] include tumors affecting head and neck cancer as a whole, others are more specific and analyze p53 expression only in the mouth [25,26,27]. In the present study a population of patients diagnosed with primary OSCC was analyzed in order to obtain a more specific result.…”

Section: Discussionmentioning

confidence: 99%

The Significance of p53 Immunoexpression with Different Clones (DO-7 and PAb-240) in Oral Squamous Cell Carcinoma

Júnior¹,

Camisasca

Bernardo³

et al. 2013

ORL

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Background/Aim: The TP53 gene is a tumor suppressor gene. Its product is a nuclear protein that regulates cell cycle arrest, apoptosis and DNA repair. Anti-p53 clones DO-7 and PAb-240 recognize the amino acid sequences 21-25 and 213-217, respectively. This study aimed to evaluate the expression of these clones and their relationship with clinicopathological features and survival analysis in oral squamous cell carcinomas (OSCC). Methods: Information on 53 primary OSCC was collected at the Brazilian National Cancer Institute. An immunohistochemical method was applied to evaluate p53 expression (DO-7 and PAb-240). Their expression was analyzed quantitatively and correlated with clinicopathological features. Kaplan-Meier survival curves and log rank test were used. Results: Immunopositivity for DO-7 was present in 64% of the cases, while 58% were positive for PAb-240. There was no correlation between immunoexpression of both antibodies and clinicopathological features or survival analysis. DO-7 expression was significantly higher (p = 0.001) than that of PAb-240. Conclusions: There were quantitative differences between the expression of the antibodies studied, which may reflect a different specificity of each one. To confirm immunohistochemical results and estimate the true prognostic role of TP53 in OSCC, it is important to perform mutation analysis.

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Section: Discussionmentioning

confidence: 99%

The Significance of p53 Immunoexpression with Different Clones (DO-7 and PAb-240) in Oral Squamous Cell Carcinoma

Júnior¹,

Camisasca

Bernardo³

et al. 2013

ORL

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“…The situation is worse in developing countries, such as India, Thailand and Brazil, 3 where this cancer is more common. 4 The mean survival rate in these patients is 5 years. 5 The 5-year life expectancy is about 50% when there are lymph node metastases.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 No significant increase in survival rates had occurred in the last few decades in spite of new surgical techniques, radiotherapy and concomitant chemotherapy. 4,5,6,8 Epidemiologic studies have suggested a multifactor etiology for this cancer; these predisposing factors include smoking, alcohol use, human papilloma virus (HPV) infection, and genetic factors. 1,4,7,9,10 Genetic polymorphisms leading to folate deficiency appear to facilitate the onset and growth of head and neck squamous cell carcinoma and other types of cancer.…”

Section: Introductionmentioning

confidence: 99%

“…4,5,6,8 Epidemiologic studies have suggested a multifactor etiology for this cancer; these predisposing factors include smoking, alcohol use, human papilloma virus (HPV) infection, and genetic factors. 1,4,7,9,10 Genetic polymorphisms leading to folate deficiency appear to facilitate the onset and growth of head and neck squamous cell carcinoma and other types of cancer. Folate is part of DNA methylation, in which methyl groups (CH3) are transferred to the 5' position of cytosine residues on cytosine-guanine (CpG) dinucleotides in reactions catalyzed by proteins (DNA methyltransferases).…”

Section: Introductionmentioning

confidence: 99%

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Polimorfismo do gene metilenotetra-hidrofolato redutase (MTHFR) e o risco de carcinoma espinocelular de cabeça e pescoço

Rodrigues¹,

Galbiatti²,

Ruiz³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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Met hylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism may be a risk factor for head and neck squamous cell carcinoma due to changes in folate levels that can induce disorders in the methylation pathway, which results in carcinogenesis. Aim:To evaluate MTHFR C677T polymorphism in patients with head and neck squamous cell carcinoma and in individuals with no history of cancer, and to assess the association of this disease with clinical histopathological parameters. Series and Methods:A retrospective study that assessed gender, age, tobacco, alcohol consumption and clinical histopathological parameters in 200 patients (100 with disease and 100 with no history of cancer). PCR-RFLP molecular analysis was carried out and the chi-square test and multiple logistic regression were applied for the statistical analysis. Results:There was no association between MTHFR C677T polymorphism and head and neck cancer (p = 0.50). Significant differences between the study and control groups were observed at age over 50 years, tobacco use, and male gender (p <0.001). There was no association of disease with clinical-histopathological parameters. Conclusion:No association between the MTHFR C677T polymorphism and head and neck squamous cell carcinoma was possible in this study. Braz J Otorhinolaryngol. 2010;76(6):776-82. ORIGINAL ARTICLE

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“…6 Currently, there is no reliable method to predict which of the patients will develop SPT. These tumors may appear due to extensive initiation and promotion by various carcinogens mainly tobacco and alcohol, leaving to a widespread disorder of the epithelial maturation and differentiation with a field effect.…”

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confidence: 99%

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

Lopes

Aquino

Morais

et al. 2015

The Journal of Contemporary Dental Practice

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Aim: This manuscript aims to describe an unusual case of multiple second primary squamous cell carcinomas (SCCs) in several sites of the oral mucosa in a nonsmoker and nondrinker woman and to discuss the diagnostic criteria, clinicopathological aspects and outcome of second primary tumor (SPT). Background:Patients treated for SCC of the head and neck are at high risk for developing SPT arising from the same dysplastic mucosal field. Currently, there is no reliable method to predict which of the patients will develop SPT. Case description:A 64-year-old nonsmoker and nondrinker woman developed several second primary oral SCCs in 7 years of follow-up, most of them being synchronic, treated by surgery without and with chemotherapy and radiotherapy. Conclusion:Patients treated for SCC require a long-term and careful follow-up as the development of SPT contributes with significantly negative impact on the prognosis.Clinical significance: This report describes the diagnosis and management of a very unusual case of several SPTs affecting different sites of the oral mucosa in the same patient. Moreover, the patient had no apparent risk factors associated

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Head and neck squamous cell carcinoma in non‐smoking and non‐drinking patients with multiple tumors: etiologic significance of p53 and Ki‐67 in non‐tumorous epithelium

Cited by 23 publications

References 25 publications

The Significance of p53 Immunoexpression with Different Clones (DO-7 and PAb-240) in Oral Squamous Cell Carcinoma

The Significance of p53 Immunoexpression with Different Clones (DO-7 and PAb-240) in Oral Squamous Cell Carcinoma

Polimorfismo do gene metilenotetra-hidrofolato redutase (MTHFR) e o risco de carcinoma espinocelular de cabeça e pescoço

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

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