Head-group effect of surfactants of cationic type in interaction with propoxylated sodium salt of polyacrylic acid in aqueous solution

Asadov, Ziyafaddin H.; Nasibova, Shafiga M.; Ahmadova, Gulnara A.; Zubkov, Fedor I.; Rahimov, Ravan A.

doi:10.1016/j.colsurfa.2017.05.024

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…Interactions between oppositely charged surfactants and synthetic polyelectrolytes are currently the focus of modern research [1][2][3][4][5][6]. This is mainly due to the possibility of the control of the properties of these systems by the variation of the chemical structure, ratio and concentration of components, molecular weight of the polymer, pH of the medium, temperature and ionic strength [7][8][9]. In addition, the fabrication of complexes can be mediated by different mechanisms, including the hydrophobic effect, van der Waals interactions and hydrogen bonding, with the contribution of dominating electrostatic interactions [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

et al. 2021

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The solution behavior and physicochemical characteristics of polymer–colloid complexes based on cationic imidazolium amphiphile with a dodecyl tail (IA-12) and polyacrylic acid (PAA) or DNA decamer (oligonucleotide) were evaluated using tensiometry, conductometry, dynamic and electrophoretic light scattering and fluorescent spectroscopy and microscopy. It has been established that PAA addition to the surfactant system resulted in a ca. 200-fold decrease in the aggregation threshold of IA-12, with the hydrodynamic diameter of complexes ranging within 100–150 nm. Electrostatic forces are assumed to be the main driving force in the formation of IA-12/PAA complexes. Factors influencing the efficacy of the complexation of IA-12 with oligonucleotide were determined. The nonconventional mode of binding with the involvement of hydrophobic interactions and the intercalation mechanism is probably responsible for the IA-12/oligonucleotide complexation, and a minor contribution of electrostatic forces occurred. The latter was supported by zeta potential measurements and the gel electrophoresis technique, which demonstrated the low degree of charge neutralization of the complexes. Importantly, cellular uptake of the IA-12/oligonucleotide complex was confirmed by fluorescence microscopy and flow cytometry data on the example of M-HeLa cells. While single IA-12 samples exhibit roughly similar cytotoxicity, IA-12–oligonucleotide complexes show a selective effect toward M-HeLa cells (IC50 1.1 µM) compared to Chang liver cells (IC50 23.1 µM).

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Section: Introductionmentioning

confidence: 99%

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

et al. 2021

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“…There are limited studies on the growth of micelle in the presence of di- and trivalent cations, − although studies are on the effect of mostly unicationic and anionic salts on the different aggregation properties of conventional surfactants. − Instead of many applications of SDDS in biological, medicinal, and industrial fields, studies on its interfacial and bulk properties are limited. There is a report on the self-aggregation behavior of the aqueous solution of SDDS in different temperatures, pHs, acidity constants, and conformational properties by our group in the presence of unicationic and anionic salts .…”

Section: Introductionmentioning

confidence: 99%

Exploring Physicochemical Interactions of Different Salts with Sodium N-Dodecanoyl Sarcosinate in Aqueous Solution

et al. 2018

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Amino acid-based surfactants are used in academics and industry. Sodium N -dodecanoyl sarcosinate (SDDS) is such an amino acid-based surfactant having applications in pharmaceutical, food, and cosmetic formulations. Although the surface properties of this surfactant have been studied in the presence of univalent cationic and anionic salts, there is no report on such solution in the presence of higher valencies. In this experiment, critical micelle concentration (CMC) of SDDS from tensiometry, conductometry, and fluorimetry has been determined. In each case, CMC decreases with increasing salt concentration. Counterion binding of micelles (β), diffusion coefficient ( D 0 ), and surface properties, e.g., Gibbs free energy for micellization (Δ G m 0 ), Gibbs surface excess (Γ max ), area of exclusion per surfactant monomer ( A min ), surface pressure at CMC (π cmc ), etc., have been evaluated using methods such as tensiometry, conductometry, and fluorimetry. The hydrodynamic radius of SDDS in the presence of different salts was measured by the light scattering method. Aggregation number and shape of micelle have been determined by small-angle neutron scattering experiment. The nature of amphiphilic packing and the aggregation numbers of the assemblies have also been explored. The results from different experiments have been rationalized and represented systematically.

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“…Even though the use of this model in the system based on oppositely charged components is documented [ 24 ], this approach is not general. In contrast to surfactant–nonionic polymer systems, the nature of the surfactant head group has a significant effect on the surfactant–PE interaction [ 18 , 25 ]. This can be exemplified by PAA–surfactant systems involving two cationic surfactants with morpholinium and triphenylphosphonium head groups.…”

Section: Introductionmentioning

confidence: 99%

Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers

et al. 2023

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Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed PE–surfactant complexes based on oppositely charged species are characterized by multifactor behavior strongly affected by the nature of both components. It was expected that the transition from a single surfactant solution to an admixture with PE might provide synergetic effects on structural characteristics and functional activity. To test this assumption, the concentration thresholds of aggregation, dimensional and charge characteristics, and solubilization capacity of amphiphiles in the presence of PEs have been determined by tensiometry, fluorescence and UV-visible spectroscopy, and dynamic and electrophoretic light scattering. Results. The formation of mixed surfactant–PAA aggregates with a hydrodynamic diameter of 100–180 nm has been shown. Polyanion additives led to a decrease in the critical micelle concentration of surfactants by two orders of magnitude (from 1 mM to 0.01 mM). A gradual increase in the zeta potential of HAS–surfactant systems from negative to positive value indicates that the electrostatic mechanism contributes to the binding of components. Additionally, 3D and conventional fluorescence spectroscopy showed that imidazolium surfactant had little effect on HSA conformation, and component binding occurs due to hydrogen bonding and Van der Waals interactions through the tryptophan amino acid residue of the protein. Surfactant–polyanion nanostructures improve the solubility of lipophilic medicines such as Warfarin, Amphotericin B, and Meloxicam. Perspectives. Surfactant–PE composition demonstrated beneficial solubilization activity and can be recommended for the construction of nanocontainers for hydrophobic drugs, with their efficacy tuned by the variation in surfactant head group and the nature of polyanions.

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Head-group effect of surfactants of cationic type in interaction with propoxylated sodium salt of polyacrylic acid in aqueous solution

Cited by 12 publications

References 29 publications

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

Exploring Physicochemical Interactions of Different Salts with Sodium N-Dodecanoyl Sarcosinate in Aqueous Solution

Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers

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