Head Injury

Turtz, Alan; Goldman, Harold

doi:10.1016/b978-032304841-5.50069-8

Cited by 1 publication

(1 citation statement)

References 267 publications

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“…Since pentobarbital reduces intracranial pressure, it is the preferred agent for SE in the setting of traumatic brain injury and large ischemic strokes. 30 While phenobarbital is also a barbiturate, its role is primarily for termination of early phase seizures that have not yet progressed to SE. 2 However, there is more recent interest in its use for focal RSE and should be considered during the initial or second therapy phases (15-20 mg/kg IV push), especially when there is impairment of consciousness due to ongoing focal seizures.…”

Section: Anesthetics For Refractory Status Epilepticusmentioning

confidence: 99%

Anesthetic Use In Status Epilepticus: A Concise Review

Yilmaz

Igneri

Yilmaz

et al. 2020

CRMJ

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The purpose of this review is to summarize the recent literature focusing on intravenous (IV) administration of commonly used anesthetics, including midazolam, pentobarbital/ thiopental, propofol, and ketamine in the treatment of status epilepticus (SE). Anesthetics should be reserved as third-line therapy for the treatment of SE when benzodiazepines and other second-line agents fail to terminate the seizure. We have reviewed the literature related to the treatment of status epilepticus, refractory status epilepticus, super-refractory status epilepticus, anesthetics, midazolam, pentobarbital/thiopental, propofol, and ketamine. This paper focuses on the pharmacology, dosages, major side effects, and clinical use of IV anesthetics in the treatment of SE with an emphasis on the developing literature supporting the use of ketamine for this indication. Based on the available literature, we propose recommendations for third-line agent selection in the management of SE.

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Section: Anesthetics For Refractory Status Epilepticusmentioning

confidence: 99%