2007
DOI: 10.1002/dvdy.21405
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Head involution in Drosophila: Genetic and morphogenetic connections to dorsal closure

Abstract: Dorsal closure and head involution are complex morphogenetic processes that occur nearly simultaneously, midway through Drosophila embryonic development. While dorsal closure has been studied extensively in terms of both its morphology and genetics, head involution has not been described comprehensively. A thorough review of the literature nonetheless reveals considerable information regarding the genetic components of head involution. In several instances, authors have made explicit references to head involut… Show more

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Cited by 29 publications
(29 citation statements)
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“…The formation of tissues and organs during embryogenesis involves a series of exquisite morphogenetic processes executed through precisely orchestrated tissue contractions, foldings and migrations that are highly dependent on dynamic coordination of the actin and microtubule cytoskeleton (reviewed in: Sweeton et al, 1991; Harden, 2002; VanHook and Letsou, 2008; Harris et al, 2009). Following the formation of a hollow ball of cells (called a cellular blastoderm), the posterior end of the Drosophila embryo migrates up and over the top (dorsal) surface in a process called germband extension, which is responsible for delivery of specific cell types to the interior of the embryo.…”
Section: Resultsmentioning
confidence: 99%
“…The formation of tissues and organs during embryogenesis involves a series of exquisite morphogenetic processes executed through precisely orchestrated tissue contractions, foldings and migrations that are highly dependent on dynamic coordination of the actin and microtubule cytoskeleton (reviewed in: Sweeton et al, 1991; Harden, 2002; VanHook and Letsou, 2008; Harris et al, 2009). Following the formation of a hollow ball of cells (called a cellular blastoderm), the posterior end of the Drosophila embryo migrates up and over the top (dorsal) surface in a process called germband extension, which is responsible for delivery of specific cell types to the interior of the embryo.…”
Section: Resultsmentioning
confidence: 99%
“…Double mutants showed a fully penetrant head defect, characterized by an anterior hole in the embryonic cuticle and anterior malformations of the cephalopharyngeal skeleton, which was not observed in either single mutant alone (Figure 4, I–L). These phenotypes are characteristic of a failure in head involution, the process by which dorsal and lateral epidermal cells spread to cover the anterior end of the embryo (VanHook and Letsou, 2008). Taken together, our genetic analyses suggest that Drak and Rok redundantly regulate epithelial morphogenesis in multiple developmental contexts.…”
Section: Resultsmentioning
confidence: 99%
“…In Drosophila, dorsal closure occurs midway through embryogenesis when epidermal sheets, originally positioned ventrally and laterally, extend to the dorsal midline where they meet and fuse (reviewed in VanHook and Letsou, 2008). As the epidermis secretes the larval cuticle, dorsal-open group mutants remain uncovered by epidermis dorsally and accordingly secrete an incomplete cuticle that is distinguished by a large dorsal hole.…”
Section: Introductionmentioning
confidence: 99%