Head Phantom Optical Properties Validation for Near-Infrared Measurements: A Comparison with Animal Tissue

Abstract

The interest in optical healthcare technologies has increased significantly over the recent years. The innovation of new optical technologies such as Near Infrared Spectroscopy (NIRS), used for the monitoring of brain perfusion, demands a comprehensive understanding and knowledge of the light tissue interaction. Phantoms can provide a rigorous, reproducible and convenient approach for evaluating an optical sensor's performance. However, up to date literature does not provide a detailed description of a complete head model that involves the human anatomy, physiological changes, and the tissue optical properties. The latter is key for the design, development and testing of optical sensors, such as NIRS technologies. This paper compared the optical properties of the materials chosen to build a head phantom, against the optical properties of real brain and skull tissues extracted from animal models. The spectra of a silicone brain and resin skull samples were compared with the spectra of the respective tissues extracted from pigs and mice. The results of this study demonstrated that both phantom materials have similar optical properties to mice and pigs' tissues. The morphology of the phantom's spectra were very similar to the respective animal tissue comparator.